non-homologous end-joining (NHEJ)

Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.

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ORTHOLOGY CLASS Homo sapiens L. (human) [HSA] Mus musculus L. (mouse) [MMU] Caenorhabditis elegans Maupas (nematode) [CEL] Drosophila melanogaster Meigen (fruit fly) [DME] Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE] Schizo-saccharomyces pombe Lindner (fission yeast) [SPO] Escherichia coli Migula (bacterium) K-12 MG1655 [ECO] Arabidopsis thaliana (L.) Heynh. (mouse-ear cress) [ATH]
ko:K10983 (non-homologous end-joining protein 1) NEJ1
ko:K10982 (ligase-interacting factor 1) LIF1
ko:K10981 (DNA polymerase IV [EC:]) POL4 pol4
ko:K10980 (non-homologous end-joining factor 1) NHEJ1 (Cernunnos) Nhej1
ko:K10887 (DNA cross-link repair 1C protein [EC:3.1.-.-]) DCLRE1C (Artemis) Dclre1c
ko:K10886 (DNA-repair protein XRCC4) XRCC4 Xrcc4 XRCC4
ko:K10885 (ATP-dependent DNA helicase 2 subunit 2) Ku80 (XRCC5) Xrcc5 cku-80 Ku80 YKU80 pku80 KU80
ko:K10884 (ATP-dependent DNA helicase 2 subunit 1) Ku70 (XRCC6) Xrcc6 cku-70 Irbp YKU70 pku70 KU70
ko:K10868 (DNA repair protein XRS2) XRS2
ko:K10866 (DNA repair protein RAD50 [EC:3.6.-.-]) RAD50 Rad50 rad-50 rad50 RAD50 rad50 RAD50
ko:K10865 (double-strand break repair protein MRE11) MRE11A Mre11a mre-11 mre11 MRE11 rad32 MRE11
ko:K10777 (DNA ligase 4 [EC:]) LIG4 Lig4 lig-4 Lig4 DNL4 lig4 ATLIG4
ko:K06642 (DNA-dependent protein kinase catalytic subunit [EC:]) DNA-PKcs (XRCC7) Prkdc
ko:K04799 (flap endonuclease-1 [EC:3.-.-.-]) FEN1 (DNase IV) Fen1 crn-1 Fen1 RAD27 rad2 AT5G26680
ko:K03513 (DNA polymerase mu subunit [EC:]) POLμ (POLM) Polm
ko:K03512 (DNA polymerase lambda subunit [EC: 4.2.99.-]) POLλ (POLL) mPolλ (mPOLL) DNA Pol lambda
ko:K00977 (DNA nucleotidylexotransferase [EC:]) DNTT (TdT) Dntt

Last modification date: Feb. 6, 2012