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chronic myeloid leukemia (CML)

Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B lymphoid, and sometimes T lymphoid cells, but not marrow fibroblasts. Silver (2003) reviewed the hematologic and clinical aspects of chronic myeloid leukemia. Geary (2000) presented a historical review of CML.
CML has a biphase or triphase clinical course (Medina et al., 2003). Approximately 90% of patients are diagnosed in the chronic phase, but the disease eventually evolves to a blastic phase unless successfully treated. Approximately two-thirds of patients manifest an accelerated phase. A distinct feature of disease progression is the appearance of additional cytogenetic abnormalities in the Ph-positive cells. This phenomenon, known as clonal evolution, frequently involves a second Ph, trisomy of chromosome 8, and isochromosome 17 and other abnormalities of chromosome 17 (Kantarjian et al., 1988), although other abnormalities have been described. Clonal evolution is considered a criterion of accelerated phase, although when it represents the only criterion of transformation, it is associated with a better prognosis than other criteria of accelerated phase (Cortes et al., 2003).
Sawyers (1999) reviewed the clinical aspects of chronic myeloid leukemia.


  • CML in MedlinePlus website MedlinePlus is the National Institutes of Health's Web site for patients and their families and friends.
KEGG ID H00004 dbget-bin/www_bget?ds:H00004

chronic granulocytic leukemia (CGL)


TYPE: CANCER, blood cell cancer

OMIM: 608232

Last modification date: Aug. 20, 2011