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multiple myeloma (AL), resistance to

Multiple myeloma is a neoplastic plasma cell disorder characterized by clonal proliferation of malignant plasma cells in the bone marrow microenvironment, monoclonal protein in the blood or urine, and associated organ dysfunction.

AL amyloidosis, formerly called primary amyloidosis, is a protein conformation disorder associated with a clonal plasma cell dyscrasia. Multiple organ disease results from the extracellular deposition of monoclonal immunoglobulin light chain fragments in an abnormal insoluble fibrillar form. AL amyloidosis may be associated with myeloma or other B-cell malignancy, but in most cases the underlying plasma cell dyscrasia is subtle and nonproliferating, analogous to MGUS.

Several chromosome aberrations, including recurrent translocations and deletions, have been found to be related to the development or progression of multiple myeloma.

Genetic variants of NHEJ LIG4 may modulate predisposition to multiple myeloma.



TYPE: blood cell cancer, chromosomal instability, immunodeficiency

Related patway(s): non-homologous end-joining (NHEJ)

DNAtraffic protein(s) related to disease: LIG4

OMIM: 254500

Last modification date: Aug. 17, 2011