Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA replication licensing factor mcm4


DESCRIPTION:
Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Required for S phase execution.

STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MSSSQQSGRA NELRTPGRAN SSSREAVDSS PLFFPASSPG STRLTTPRTT ARTPLASSPL
        70         80         90        100        110        120
LFESSSPGPN IPQSSRSHLL SQRNDLFLDS SSQRTPRSTR RGDIHSSVQM STPSRRREVD
       130        140        150        160        170        180
PQRPGVSTPS SLLFSGSDAL TFSQAHPSSE VADDTVRVIW GTNVSIQESI ASFRGFLRGF
       190        200        210        220        230        240
KKKYRPEYRN ELMPPPDAEQ LVYIEALRNM RIMGLEILNL DVQDLKHYPP TKKLYHQLYS
       250        260        270        280        290        300
YPQEIIPIMD QTIKDVMLDL LGTNPPEDVL NDIELKIYKI RPFNLEKCIN MRDLNPGDID
       310        320        330        340        350        360
KLISIKGLVL RCTPVIPDMK QAFFRCSVCG HCVTVEIDRG RIAEPIKCPR EVCGATNAMQ
       370        380        390        400        410        420
LIHNRSEFAD KQVIKLQETP DVVPDGQTPH SVSLCVYDEL VDSARAGDRI EVTGIFRCVP
       430        440        450        460        470        480
VRLNPRMRTV KSLFKTYVDV VHIKKQDKRR LGTDPSTLES DIAEDAALQI DEVRKISDEE
       490        500        510        520        530        540
VEKIQQVSKR DDIYDILSRS LAPSIYEMDD VKKGLLLQLF GGTNKSFHKG ASPRYRGDIN
       550        560        570        580        590        600
ILMCGDPSTS KSQILKYVHK IAPRGVYTSG KGSSAVGLTA YITRDQDTKQ LVLESGALVL
       610        620        630        640        650        660
SDGGICCIDE FDKMSDATRS ILHEVMEQQT VTVAKAGIIT TLNARTSILA SANPIGSKYN
       670        680        690        700        710        720
PDLPVTKNID LPPTLLSRFD LVYLILDRVD ETLDRKLANH IVSMYMEDTP EHATDMEVFS
       730        740        750        760        770        780
VEFLTSYITY ARNNINPVIS EEAAKELVNA YVGMRKLGED VRASEKRITA TTRQLESMIR
       790        800        810        820        830        840
LSEAHAKMHL RNVVEVGDVL EAARLIKTAI KDYATDPATG KISLDLIYVN ERETLVPEDM
       850        860        870        880        890        900
VKELANLISN LTVGGKTMLV SQLLTRFREQ SSTRLDASDF EACLGALERR GRIKVITSAG
       910
HRIVRSIAQT D    

Encoded by cdc21 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgtcctcta gtcagcaaag tggcagagcc aatgagttga ggactcctgg aagagctaac
        70         80         90        100        110        120
agctcttcaa gagaagcagt ggattcttct ccgttatttt ttcctgcttc gtctcctggt
       130        140        150        160        170        180
tctacacgcc ttacaacacc gaggactaca gcgcgtacac ctctcgcttc ctctccttta
       190        200        210        220        230        240
ctgtttgaat ctagttcacc aggtccaaac attcctcaga gttcacgttc tcatctttta
       250        260        270        280        290        300
tctcagcgta atgacttgtt ccttgacagt agttcgcaga gaacaccgcg ctcgacaaga
       310        320        330        340        350        360
cgtggagaca tccattctag cgtgcaaatg tctaccccat ctcgtcgaag agaagttgac
       370        380        390        400        410        420
cctcaacgtc ccggggtaag cactcctagt agcttgttgt tttctgggtc agatgcactc
       430        440        450        460        470        480
acgtttagtc aggcgcaccc aagcagtgaa gtagctgatg acactgtccg tgtcatttgg
       490        500        510        520        530        540
ggaacaaatg tatctattca agaaagtatc gcttcctttc gtggatttct acgtgggttt
       550        560        570        580        590        600
aagaaaaagt atcgacctga atacagaaat gaacttatgc cacctcctga tgccgaacaa
       610        620        630        640        650        660
ctagtgtata ttgaagcgct acgaaacatg cgtattatgg gtttggaaat attaaatctt
       670        680        690        700        710        720
gatgttcagg atttaaagca ttatccccca accaagaagc tatatcacca gctttactca
       730        740        750        760        770        780
taccctcaag aaatcattcc tatcatggat caaaccatta aagacgttat gctagacttg
       790        800        810        820        830        840
ttaggaacta atcctcccga agatgttctt aatgacattg agcttaaaat ttacaaaatt
       850        860        870        880        890        900
cgtcctttta atcttgaaaa atgcattaat atgcgtgatc ttaatcctgg tgacattgac
       910        920        930        940        950        960
aaattgatct ctattaaagg tctggtactt aggtgtacac ctgtaatacc cgacatgaag
       970        980        990       1000       1010       1020
caagcatttt ttcgatgttc agtttgtggt cattgtgtta ccgtggaaat cgatagaggg
      1030       1040       1050       1060       1070       1080
cgaattgctg agcccataaa atgccctaga gaagtctgtg gtgctacaaa tgcaatgcag
      1090       1100       1110       1120       1130       1140
ctaattcata atcgttctga attcgccgat aagcaagtta ttaaactcca agagacacct
      1150       1160       1170       1180       1190       1200
gacgtggtac cggatggcca aaccccacac tctgtaagtc tgtgcgtata tgatgaactg
      1210       1220       1230       1240       1250       1260
gttgactctg ctagagcagg agatcgtata gaagtcactg ggatttttcg ctgtgtacca
      1270       1280       1290       1300       1310       1320
gttcgtttga accctcgcat gcgtactgta aaatcattat ttaaaactta tgtcgacgtt
      1330       1340       1350       1360       1370       1380
gttcacataa aaaagcagga caaacgtcgt ttgggtacgg atccttctac gttggaaagc
      1390       1400       1410       1420       1430       1440
gatattgctg aagatgctgc tttacaaatt gatgaagtac ggaaaatatc agacgaagaa
      1450       1460       1470       1480       1490       1500
gtggaaaaaa ttcaacaagt ttcaaagcgg gacgatatat acgatattct ttcccggtct
      1510       1520       1530       1540       1550       1560
ctggcaccta gcatttacga aatggatgat gttaaaaagg ggcttttgct acagctattt
      1570       1580       1590       1600       1610       1620
ggtggaacga acaagtcttt tcataaaggc gcaagtccga gatatcgtgg agacataaat
      1630       1640       1650       1660       1670       1680
atcttgatgt gtggtgatcc atctacgtct aagtctcaaa ttttgaagta tgtccataag
      1690       1700       1710       1720       1730       1740
atagcaccca gaggtgttta cactagtggc aagggttcat ctgctgttgg tttaactgcc
      1750       1760       1770       1780       1790       1800
tatattactc gtgaccaaga cacgaagcaa ctagtcttgg aaagtggtgc tttggtactg
      1810       1820       1830       1840       1850       1860
tcagatgggg gcatttgctg cattgatgag tttgacaaaa tgtccgatgc tacacgttct
      1870       1880       1890       1900       1910       1920
attcttcatg aagttatgga gcagcaaacc gttacagttg ccaaggctgg cattattact
      1930       1940       1950       1960       1970       1980
actttgaacg ctaggacttc tattttagct agtgcaaatc caattggaag caaatacaat
      1990       2000       2010       2020       2030       2040
ccagacttgc ctgtcaccaa aaatattgat cttccgccta ctctcttatc tagatttgat
      2050       2060       2070       2080       2090       2100
ttggtgtatt taatattaga ccgcgtggat gaaacgctgg ataggaagct cgcaaatcat
      2110       2120       2130       2140       2150       2160
attgtttcta tgtacatgga agatactcct gaacatgcta cagatatgga ggtctttagt
      2170       2180       2190       2200       2210       2220
gtggaatttt tgacaagcta tatcacatat gctagaaata atattaatcc tgtcattagt
      2230       2240       2250       2260       2270       2280
gaagaggcag caaaggaact agtgaatgct tatgttggta tgcgaaagct tggggaggat
      2290       2300       2310       2320       2330       2340
gtgcgagcat ctgagaaaag aattactgct acaacaagac aactggaatc aatgattcgt
      2350       2360       2370       2380       2390       2400
ctatctgagg cccatgcgaa aatgcatctt cgcaacgttg ttgaggtagg agatgttctt
      2410       2420       2430       2440       2450       2460
gaagctgctc gcttgattaa gaccgctatt aaggattatg caactgatcc tgcaacagga
      2470       2480       2490       2500       2510       2520
aagatttctc ttgacctaat ttatgttaat gaaagagaga ctttggtacc tgaagatatg
      2530       2540       2550       2560       2570       2580
gtcaaagaac tggcgaattt aatttcaaat ttaactgtgg gtggaaaaac tatgttggtc
      2590       2600       2610       2620       2630       2640
agtcaattgt taactcggtt tcgtgagcag agttctactc gcttagatgc ttctgatttc
      2650       2660       2670       2680       2690       2700
gaagcttgtc tgggtgcttt ggaaaggcga ggacgtatta aggttattac cagtgctgga
      2710       2720       2730
catcgcattg tacgttcaat tgcacagact gattaa  

Last modification date: Oct. 2, 2011