Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA replication licensing factor mcm3


DESCRIPTION:
Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity).

STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MTELLADEVF KDRVRIFQEY LEHDTDDANV TLYQEAILRM LNMGQRRLIV NIDELRDYNR
        70         80         90        100        110        120
ELADGVLLKP LEYVEPFDEA LRNVVSTLID PVVHKDLKDK LFYVGFRGSF GDHHVNPRTL
       130        140        150        160        170        180
RAMHLNKMIS LEGIVTRCSF VRPKVIKSVH YCEATKRHHF KQYADATMNG GLSFQSTVYP
       190        200        210        220        230        240
TQDENGNPLS IEFGFSTFRD HQSISLQEMP ERAPPGQLPR SIDILLDDDL VDTVKPGDRV
       250        260        270        280        290        300
NIVGQYRSMG SKTSGNTSAT FRTVLLANNV VLLGNKPGLG NVGGGALDIT DADIRNINKL
       310        320        330        340        350        360
ARKKNVFELL STSLAPSIYG YEYVKQAILL LLLGGTEKNL TNGTHIRGDI NILMVGDPST
       370        380        390        400        410        420
AKSQLLRFVL NTAPLAIATT GRGSSGVGLT AAVTTDKETG ERRLEAGAMV LADRGVVCID
       430        440        450        460        470        480
EFDKMSDIDR VAIHEVMEQQ TVTIAKAGIH TSLNARCSVI AAANPIYGQY DIRKDPHQNI
       490        500        510        520        530        540
ALPDSMLSRF DLLFIVTDDI DDKKDRALSE HVLRMHRYLP PGVEPGTPVR DSLNSVLNVG
       550        560        570        580        590        600
ATNAAGVSTE NVEQEVETPV WETFSSLLHA NARTKKKELL NINFVRKYIQ YAKSRIHPIL
       610        620        630        640        650        660
NQATAEYITN IYCGLRNDDL QGNQRRTSPL TARTLETLIR LSTAHAKARL SSVVEVKDAK
       670        680        690        700        710        720
AAEKILRYAL FREVVKPKRK KHKKQRLEAG EEFDSEDDNS DDMDIEESEE EMDTNMVIDS
       730        740        750        760        770        780
GSRRVTRSQN ATSQSQESGS EIGSSIAGTA GSYNVGTSNT QLSWPSTHST LPATSRELAS
       790        800        810        820        830        840
SDRNINTGTS VASEVSASVS EQSTVSLPRE KMSVFMARLA SLTKSELFSE ECASLEDVLE
       850        860        870
SINNIEDDVG FSREEAIVAL KEMDAQNKIM FSDNVVYRI  

Encoded by mcm3 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgactgagc tgttagcaga tgaggttttt aaagaccgtg ttagaatttt tcaagaatat
        70         80         90        100        110        120
cttgaacatg acactgatga tgctaacgtt accttgtacc aagaggcaat ccttagaatg
       130        140        150        160        170        180
cttaacatgg gtcagcgtcg tttaattgtc aatattgatg aactgcgcga ttacaaccga
       190        200        210        220        230        240
gaattagctg atggtgttct tttgaagcct cttgaatatg tggaaccttt tgatgaggca
       250        260        270        280        290        300
ttgagaaatg tagttagcac tctcatagat cctgttgttc ataaggacct aaaggataag
       310        320        330        340        350        360
ctgttttacg tgggtttcag gggatcgttt ggtgaccacc atgtgaatcc acgtactttg
       370        380        390        400        410        420
agagccatgc atttaaataa gatgatttct ctggaaggaa ttgttacgcg ctgctctttt
       430        440        450        460        470        480
gttcgtccta aagtaattaa atctgttcat tactgcgaag ctacaaaaag acatcatttc
       490        500        510        520        530        540
aaacaatatg ccgatgctac tatgaatggc ggccttagct ttcaatccac tgtatatcca
       550        560        570        580        590        600
acacaagacg aaaacggtaa tcccctatca atagaatttg gcttcagcac ctttcgcgat
       610        620        630        640        650        660
catcagtcaa tttctcttca ggaaatgcct gaacgtgcac caccaggaca acttcctaga
       670        680        690        700        710        720
tcaattgaca ttttgttgga tgatgactta gttgatactg ttaaacctgg tgatcgtgtt
       730        740        750        760        770        780
aatatagtag gacaatatcg ttctatgggg tctaaaacat ctggtaatac aagcgcgacg
       790        800        810        820        830        840
tttcgaactg tgctgctagc gaacaatgtt gttttgttag ggaataaacc tggtttggga
       850        860        870        880        890        900
aatgttggtg gtggtgcatt agacatcact gatgctgata ttcgtaacat aaataaattg
       910        920        930        940        950        960
gccagaaaaa aaaatgtgtt tgaacttctc tctacgagtc ttgctcccag tatttatggc
       970        980        990       1000       1010       1020
tatgaatacg tcaagcaagc aattttactt cttcttctgg gaggaactga aaaaaatttg
      1030       1040       1050       1060       1070       1080
acgaatggaa ctcatattcg tggtgatata aatattttga tggttggtga tccgtccact
      1090       1100       1110       1120       1130       1140
gcaaaatctc aacttcttag atttgtactt aataccgctc cacttgctat agctacgact
      1150       1160       1170       1180       1190       1200
ggtcgtggtt cttctggcgt aggtttaact gctgcagtga ccacagataa agaaactggc
      1210       1220       1230       1240       1250       1260
gagcgtcgtt tagaggctgg tgccatggta ttagcagacc gtggcgtggt ttgcattgat
      1270       1280       1290       1300       1310       1320
gagtttgaca agatgagtga catagataga gttgctattc atgaagttat ggaacaacag
      1330       1340       1350       1360       1370       1380
acagttacga ttgctaaagc cggtattcat acttcgctta atgctcggtg tagtgtgatt
      1390       1400       1410       1420       1430       1440
gccgctgcaa atcctatata tggacaatac gatattcgta aagatcctca ccaaaatata
      1450       1460       1470       1480       1490       1500
gcacttccag attctatgct ttcgcgtttt gaccttcttt tcattgttac agatgatatc
      1510       1520       1530       1540       1550       1560
gatgataaaa aggaccgtgc tctcagtgag catgtattga gaatgcatcg ttacttgcct
      1570       1580       1590       1600       1610       1620
cctggtgttg agccaggtac gccggttcgt gattccttaa acagtgtatt aaacgttgga
      1630       1640       1650       1660       1670       1680
gctacaaacg ctgctggtgt ctctacggaa aacgttgaac aggaagttga gactccagtc
      1690       1700       1710       1720       1730       1740
tgggaaacat tttcaagtct tttgcatgcg aatgctcgaa cgaagaagaa agaattgctt
      1750       1760       1770       1780       1790       1800
aacatcaact ttgtgcggaa atatattcag tatgcaaaat ctcgtatcca ccctattctg
      1810       1820       1830       1840       1850       1860
aatcaagcaa ccgctgagta cattaccaat atttattgtg ggttacgaaa tgacgattta
      1870       1880       1890       1900       1910       1920
caaggaaacc agcggcgcac aagtcccttg acggcacgta ctttagaaac cttgattcga
      1930       1940       1950       1960       1970       1980
ttaagtactg ctcacgccaa agcacgtttg agctcagttg tggaagtcaa agatgcaaag
      1990       2000       2010       2020       2030       2040
gctgcggaaa aaattttgcg ttatgctttg tttcgtgaag ttgttaaacc gaaaaggaag
      2050       2060       2070       2080       2090       2100
aagcacaaaa aacaacgcct agaggctggt gaagagtttg actcagaaga cgataattcc
      2110       2120       2130       2140       2150       2160
gatgacatgg atattgagga atctgaagaa gaaatggata caaacatggt cattgattcg
      2170       2180       2190       2200       2210       2220
ggatcgagaa gagttacccg atctcagaat gcaacttcgc aaagtcaaga atctggttcg
      2230       2240       2250       2260       2270       2280
gagattggtt caagtatcgc tggaacagct ggttcctata atgtaggaac atcaaatacc
      2290       2300       2310       2320       2330       2340
cagttatcat ggccttccac tcactcgacc ttaccagcta catcgagaga gctagccagc
      2350       2360       2370       2380       2390       2400
agtgaccgta acatcaatac aggcactagc gtggcttctg aagtgtcggc atctgtgagc
      2410       2420       2430       2440       2450       2460
gagcagagca cagtttcatt acctcgtgag aagatgtctg tgttcatggc ccggttggct
      2470       2480       2490       2500       2510       2520
tcccttacaa aatccgagct gttctcagaa gagtgtgcct ctttggaaga tgttttggaa
      2530       2540       2550       2560       2570       2580
tcaattaata atatcgagga tgatgtagga ttttcgagag aagaagctat tgtggcactt
      2590       2600       2610       2620       2630       2640
aaagaaatgg acgctcagaa caagatcatg ttttcagata atgtggttta tcgtatttaa

Last modification date: Oct. 2, 2011