Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA replication licensing factor mcm2


DESCRIPTION:
Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Plays an important role in DNA replication.

STRUCTURE SIMILARITY:
Contains 1 MCM domain.
Belongs to the MCM family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MDSFRKRGRR DSESLPFESE NSSLGATPLS LPPSSPPPEF SDEAAEALVE EDIEDLDGEA
        70         80         90        100        110        120
LDVEDEEGED LFGEGMERDY QQNLELDRYD IEELDDDNDL EELDIGARRA VDARLRRRDI
       130        140        150        160        170        180
ELDAAAGRTK PAAFLQDEDD DLDSNLGTGF TRHRHRIYDE YSPNVGALDE SGELPLESIA
       190        200        210        220        230        240
DVKADSIAEW VTLDPVRRTI AREFKNFLLE YTDENGTSVY GNRIRTLGEV NAESLMVNYA
       250        260        270        280        290        300
HLGESKPILA YFLANAPAPI FRIFDRVALE ATLLHYPDYE RIHSDIHVRI TNLPTCFTLR
       310        320        330        340        350        360
DLRQSHLNCL VRVSGVVTRR TGLFPQLKYI RFTCTKCGAT LGPFFQDSSV EVKISFCHNC
       370        380        390        400        410        420
SSRGPFVINS ERTVYNNYQR ITLQESPGTV PSGRLPRHRE VILLADLVDV AKPGEEIDVT
       430        440        450        460        470        480
GIYRNNFDAS LNTKNGFPVF ATIIEANHIS QLDGSGNTDD DFSLSRLTDD EEREIRALAK
       490        500        510        520        530        540
SPDIHNRIIA SMAPSIYGHR SIKTAIAAAL FGGVPKNING KHKIRGDINV LLLGDPGTAK
       550        560        570        580        590        600
SQFLKYVEKT AHRAVFATGQ GASAVGLTAS VRKDPITNEW TLEGGALVLA DKGVCLIDEF
       610        620        630        640        650        660
DKMNDQDRTS IHEAMEQQSI SISKAGIVTT LQARCTIIAA ANPIGGRYNT TIPFNQNVEL
       670        680        690        700        710        720
TEPILSRFDI LQVVKDTVNP EIDEQLANFV VSSHIRSHPA FDPNMDVLKK VPTETGIDAK
       730        740        750        760        770        780
PIPQDLLRKY IHFAREKVFP RLQQMDEEKI SRLYSDMRRE SLATGSYPIT VRHLESAIRL
       790        800        810        820        830
SEAFAKMQLS EFVRPSHIDK AIQVIIDSFV NAQKMSVKRS LSRTFAKYLI 

Encoded by mcm2 gene


Nucleic acid sequence

        10         20         30         40         50         60
atggattctt ttcggaaaag gggtcgccgc gattctgaaa gtttaccttt tgaatcagaa
        70         80         90        100        110        120
aattcttctc tcggtgctac acctctttct ttacctcctt cttcacctcc tccagaattc
       130        140        150        160        170        180
tctgatgaag ctgcagaagc tctcgtggag gaggatattg aggatctgga cggagaagct
       190        200        210        220        230        240
ttagatgtag aggatgaaga aggtgaagat ttgttcggag aaggaatgga acgtgattat
       250        260        270        280        290        300
caacaaaatt tggagctaga tcgttatgac attgaagaac tagatgacga taacgatctt
       310        320        330        340        350        360
gaagaattag atatcggggc ccgaagagct gttgatgcca ggttgagacg acgtgatatt
       370        380        390        400        410        420
gagctcgatg ctgctgcagg tagaacaaaa cctgctgcat ttttacaaga tgaagatgat
       430        440        450        460        470        480
gatttggact ccaatcttgg cacaggcttc actcgtcatc gacatcgaat ttacgacgaa
       490        500        510        520        530        540
tattcaccta atgttggcgc attggacgaa tctggtgaac ttcctcttga atcaattgcc
       550        560        570        580        590        600
gacgtaaagg ccgatagtat tgccgaatgg gttactcttg atcctgttcg gcgtacaatt
       610        620        630        640        650        660
gctcgagaat tcaaaaattt ccttcttgaa tatacagatg aaaatggcac ctctgtatac
       670        680        690        700        710        720
ggtaaccgta ttcgcacatt gggtgaggtt aatgctgagt cgttgatggt taattatgcc
       730        740        750        760        770        780
catcttggtg aatctaaacc cattttggct tatttcttgg ccaatgcgcc tgcacctatt
       790        800        810        820        830        840
tttcgcatat ttgatcgtgt tgctttggaa gccactcttt tgcattatcc agactatgaa
       850        860        870        880        890        900
agaatacact ctgatattca tgttcgtatc actaatcttc ctacttgttt tactttacgc
       910        920        930        940        950        960
gatctacgac aatcccatct taattgcctt gtacgggtat ctggtgtcgt aactaggcgc
       970        980        990       1000       1010       1020
actgggcttt ttccacaatt aaaatacatt cggtttacat gtaccaaatg tggtgctact
      1030       1040       1050       1060       1070       1080
ttgggtccat tttttcaaga ctctagcgtt gaagtaaaaa tttctttctg tcacaactgt
      1090       1100       1110       1120       1130       1140
tccagccgtg gtccgtttgt aatcaactct gaacggactg tatataataa ctatcaaagg
      1150       1160       1170       1180       1190       1200
atcactttac aagaatcacc tggcaccgtc ccctcaggta gactgcctcg acaccgtgaa
      1210       1220       1230       1240       1250       1260
gttattcttt tagcggactt ggttgatgtt gccaaaccag gcgaagagat tgatgttact
      1270       1280       1290       1300       1310       1320
ggcatatacc gcaataactt cgatgctagt ctgaatacca aaaacgggtt tcctgtcttc
      1330       1340       1350       1360       1370       1380
gctacaatta tagaagcaaa tcacatatcg caacttgacg gcagtggtaa tactgatgat
      1390       1400       1410       1420       1430       1440
gatttctctt taagtcggct tactgatgat gaggaaaggg aaattcgggc attagcaaag
      1450       1460       1470       1480       1490       1500
tcgcctgata ttcacaacag aattattgca tcgatggcgc cttctattta tggacatcgc
      1510       1520       1530       1540       1550       1560
tctatcaaaa ctgctattgc tgctgcttta ttcggtggtg tccccaaaaa tattaacggt
      1570       1580       1590       1600       1610       1620
aagcataaaa ttagaggtga tatcaatgtt ttattgttgg gagatccagg aaccgccaaa
      1630       1640       1650       1660       1670       1680
tctcaatttc ttaagtatgt tgaaaaaacg gcacataggg ctgtcttcgc cacaggtcag
      1690       1700       1710       1720       1730       1740
ggtgccagtg ctgttggtct aactgcatcc gtccgtaaag accccattac gaatgaatgg
      1750       1760       1770       1780       1790       1800
actttggaag ggggtgcttt ggttttagca gataaaggtg tttgtttgat tgacgagttc
      1810       1820       1830       1840       1850       1860
gataaaatga atgatcagga tcgtacttct attcacgaag ccatggaaca acaaagtatt
      1870       1880       1890       1900       1910       1920
tctatttcta aggcgggtat tgtgactacc ttgcaggcga ggtgcactat tattgctgcc
      1930       1940       1950       1960       1970       1980
gctaatccca tcggtggacg ttataacact acaattcctt ttaatcaaaa tgttgagctg
      1990       2000       2010       2020       2030       2040
accgaaccta ttttatctcg ttttgacatc cttcaggtcg tcaaagacac ggttaatcct
      2050       2060       2070       2080       2090       2100
gaaattgatg aacagctagc taattttgtt gtatcaagtc atattcgatc tcatcctgca
      2110       2120       2130       2140       2150       2160
tttgatccga atatggatgt cttgaagaaa gtccctactg agactggtat tgatgccaaa
      2170       2180       2190       2200       2210       2220
cccattcccc aagatcttct tcgtaaatat atccatttcg ctcgtgaaaa agtttttcct
      2230       2240       2250       2260       2270       2280
cgattacagc aaatggatga agaaaagatt tcgagacttt atagcgatat gagacgcgag
      2290       2300       2310       2320       2330       2340
tcactggcta ctggaagtta tcctattact gtgcgtcatc tggagtctgc tatccgttta
      2350       2360       2370       2380       2390       2400
agtgaagcat ttgcaaaaat gcagctcagt gagtttgtgc gcccttcaca tatagacaaa
      2410       2420       2430       2440       2450       2460
gccattcaag tgattattga ttcctttgtg aatgcccaaa aaatgagtgt taaacgaagt
      2470       2480       2490
ttgtcaagaa catttgctaa atatcttatt taa  

Last modification date: Oct. 2, 2011