Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA-directed RNA polymerases I, II, and III subunit RPABC2


DESCRIPTION:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB6 is part of the clamp element and togther with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).

STRUCTURE SIMILARITY:
Belongs to the archaeal rpoK/eukaryotic RPB6 RNA polymerase subunit family.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated.


RELATED PATHWAY(S):
transcription


Amino acids sequence

        10         20         30         40         50         60
MSDYEEDEAF GMDGAVMEEE VDELEMIDEN GQSQQGVSHP GEPSTTVITE DVASSKTAQS
        70         80         90        100        110        120
GKAVAKEDRT TTPYMTKYER ARILGTRALQ ISMNAPVLVD LEGETDPLQI AMKELAQKKI
       130        140
PLLVRRYLPD GSYEDWSVAE LI   

Encoded by rpb6 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgtctgact atgaagagga tgaggccttt ggaatggacg gtgctgttat ggaggaggaa
        70         80         90        100        110        120
gtcgatgaac tggagatgat cgatgaaaat gggcaatcac agcaaggcgt ctctcatcct
       130        140        150        160        170        180
ggtgaacctt cgactaccgt tattactgaa gatgttgcta gctcaaaaac agctcaatct
       190        200        210        220        230        240
ggtaaagcgg tagcaaagga agaccgaacc actactcctt atatgacaaa gtatgaacgc
       250        260        270        280        290        300
gctcgtattt tgggaactcg agcacttcaa attagtatga acgcacctgt tttagttgat
       310        320        330        340        350        360
ttggaaggtg aaactgatcc tttgcaaatt gccatgaagg agcttgcaca aaaaaagatt
       370        380        390        400        410        420
cctctactag tccggcgata tttacccgat ggcagttatg aagactggag tgtagcggag

ctcatttaa     

Last modification date: Oct. 2, 2011