Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA-directed RNA polymerase II subunit rpb7


DESCRIPTION:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity).

STRUCTURE SIMILARITY:
Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.


RELATED PATHWAY(S):
transcription


Amino acids sequence

        10         20         30         40         50         60
MPFFLKELSL TISLHPSYFG PRMQDYLKAK LLADVEGTCS GQYGYIICVL DSNTIDIDKG
        70         80         90        100        110        120
RVVPGQGFAE FEVKYRAVLW RPFRGEVVDA IVTTVNKMGF FANIGPLNVF VSSHLVPPDM
       130        140        150        160        170
KFDPTANPPN YSGEDQVIEK GSNVRLKIVG TRTDATEIFA IATMKEDYLG VL

Encoded by rpb7 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgcctttct tcctcaaaga gctttcgtta acgatttctc tgcatcccag ttacttcggt
        70         80         90        100        110        120
cctagaatgc aggactattt aaaggcaaaa ttgttggcgg acgtggaagg cacatgctca
       130        140        150        160        170        180
ggtcaatatg gctatataat ttgcgttttg gacagtaata ctatagatat tgataaaggg
       190        200        210        220        230        240
agggtagttc ctgggcaagg gtttgccgaa tttgaggtaa agtatcgtgc agtgttatgg
       250        260        270        280        290        300
agaccatttc gtggggaagt ggtcgatgca attgttacaa cagtaaataa aatgggattc
       310        320        330        340        350        360
ttcgcaaata taggaccatt aaatgtcttt gtctcatctc atttggtgcc tccagatatg
       370        380        390        400        410        420
aagtttgacc ctactgcaaa ccctcctaat tattctggtg aggatcaagt tattgaaaag
       430        440        450        460        470        480
gggtcgaatg tcagacttaa gattgtcggt acaaggactg atgcaaccga aatttttgcc
       490        500        510
attgcaacaa tgaaagagga ttatctaggc gttctttaa  

Last modification date: Oct. 2, 2011