Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA polymerase epsilon subunit B


DESCRIPTION:
DNA polymerase II participates in chromosomal DNA replication.

MISCELLANEOUS:
In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase epsilon subunit B family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MNNSITDSVE KKPEQVSFEV QPNALRPVAF HVFTRKYDLN INRDSLQELA SFVSKKCGSQ
        70         80         90        100        110        120
WRSQCEPLLD EIAKTWKRVH ETQPIVTRPL LIPVLANLNV PHEVRVSSLA RVQTLETTGS
       130        140        150        160        170        180
FLNSSNSEIR ETIKNEKYFR VLDAFKMPKF KYDSSRKVFV LSKQSPTLMA SASACTDMLN
       190        200        210        220        230        240
RRFNVVYSRI LRNESFQTPS FSGSFSQTGT YQLTPIRNLL GRAGNTFLLF GLLTIAPDGT
       250        260        270        280        290        300
LWLEDLDSQV QLDVSQAEQG FGLFCPGCLV LVNGQFLSSG LFLVFELGHP PIERRDASLK
       310        320        330        340        350        360
ALNNLDILGL NMDAKQLALL RHAEQAYQSQ AFVCISEVHL DNHQTFYALE KIFQKYESSE
       370        380        390        400        410        420
AVPFCIILCG SFMSSAFHNS GSSIQYKEGF NKLAASLEKF PKICEKTKFI FVPGPNDPWT
       430        440        450        460        470        480
TNGISLMPKH SIPLHFVNRI QRVCKHTIFA SNPCRIIFFS QEVLIYRDDI SGRFQRNSLK
       490        500        510        520        530        540
FGKTPQGTSN INSIPLAEQQ VHQQRKLVKT VLDQSHLSPF PSRTRPILWD FDYALSVFPL
       550        560        570        580        590
PSCMGLIDSE SSAFDVHYGG CPTFNPGALL LGVHYNWQEV FPVKKEIITH KERI

Encoded by dpb2 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgaacaatt ccattacgga ttcggtagaa aaaaaacctg aacaggttag ttttgaagtt
        70         80         90        100        110        120
caacccaatg cccttcgtcc ggttgctttc cacgtattta ccaggaagta cgatctcaat
       130        140        150        160        170        180
attaatcgtg actcactgca ggaattagca tctttcgtat ctaaaaaatg cggctcacaa
       190        200        210        220        230        240
tggcgttccc aatgtgagcc cttactagac gaaattgcaa aaacttggaa acgagttcat
       250        260        270        280        290        300
gaaactcaac ctatagttac tcgacctctt ttgatccctg tcttggcaaa tttaaatgtt
       310        320        330        340        350        360
ccgcatgaag ttcgcgtatc ttccttagca agagttcaaa cgcttgagac aaccggttca
       370        380        390        400        410        420
tttttaaatt cgagtaattc ggaaatccgt gaaactataa aaaatgagaa atactttaga
       430        440        450        460        470        480
gtccttgatg cttttaaaat gcctaaattt aagtacgatt catcaagaaa ggttttcgtt
       490        500        510        520        530        540
ttatcaaaac agtctcctac tttaatggca tctgcaagtg cctgcacaga tatgcttaac
       550        560        570        580        590        600
cgcagattca atgttgtata tagccgtatt ttacgcaatg aatcttttca aacaccttct
       610        620        630        640        650        660
ttcagtggct ctttctctca aacaggtaca tatcaattaa ctcctattcg caatttatta
       670        680        690        700        710        720
ggtcgagctg gaaacacatt tttgttgttc ggactcttga ctatagctcc cgatggtacc
       730        740        750        760        770        780
ttatggctgg aagatcttga cagtcaagtt caactagacg tatcacaggc agaacaaggg
       790        800        810        820        830        840
ttcggtctct tttgccctgg ctgcttggta cttgttaatg gtcaatttct aagttctggg
       850        860        870        880        890        900
ctatttttag tttttgagct tggtcatcct cccattgaac gccgtgatgc ttccttgaag
       910        920        930        940        950        960
gcccttaata atttagatat tttggggttg aatatggatg caaagcaact tgctcttctc
       970        980        990       1000       1010       1020
cgtcacgcgg aacaggcata tcagtcacaa gcttttgttt gtatcagcga ggttcatctt
      1030       1040       1050       1060       1070       1080
gacaaccatc aaactttcta tgcattagaa aaaatattcc aaaaatatga atcctctgaa
      1090       1100       1110       1120       1130       1140
gctgtgccgt tttgtataat attatgtgga agttttatgt cttccgcttt ccataattca
      1150       1160       1170       1180       1190       1200
ggaagctcaa ttcaatataa agaaggattt aataagcttg cagcttctct tgagaagttt
      1210       1220       1230       1240       1250       1260
ccaaaaattt gcgaaaagac aaaattcata tttgtccccg gtccaaacga cccttggacg
      1270       1280       1290       1300       1310       1320
acaaatggga tatccttaat gcctaagcat tcaatacccc ttcatttcgt aaatcggatc
      1330       1340       1350       1360       1370       1380
caacgcgttt gtaagcatac cattttcgct tcaaaccctt gccgcatcat tttcttttct
      1390       1400       1410       1420       1430       1440
caggaagtac taatttatag agacgatata tcaggaagat ttcaaaggaa ttcattaaag
      1450       1460       1470       1480       1490       1500
tttgggaaga ctccccaagg tacctccaat attaattcta taccccttgc agaacaacaa
      1510       1520       1530       1540       1550       1560
gtgcatcagc aaagaaaatt ggttaaaaca gttttagatc agtctcacct ttcaccgttt
      1570       1580       1590       1600       1610       1620
ccatcgagaa cacgaccaat attgtgggat tttgattatg ctttatcagt tttcccgctt
      1630       1640       1650       1660       1670       1680
cctagctgta tgggtctaat agattctgag tcgtcggcgt ttgatgttca ttatggaggt
      1690       1700       1710       1720       1730       1740
tgcccaactt ttaatcccgg tgctctttta cttggcgttc actataattg gcaagaagta
      1750       1760       1770       1780
tttccagtaa aaaaagaaat aattacacac aaggagagaa tttag 

Last modification date: Oct. 2, 2011