Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA polymerase epsilon catalytic subunit A


DESCRIPTION:
DNA polymerase II participates in chromosomal DNA replication (By similarity).

STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-B family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)


Amino acids sequence

        10         20         30         40         50         60
MPLKTARGAS KYQFRKFNGN YNGKSKSNGR TFAKSTEEVG FNDPMKIVYK KNEIDRMMGF
        70         80         90        100        110        120
DSYEGGQPRE AWLLNVHPTV IESTKGNSTL SAVDFYFIQD DGDTFRCTIP YSPYFYIAAR
       130        140        150        160        170        180
EGKEALVDDY LKKKFVGLIK STTRIFKEDL QLKNHIVGYQ KLYIKLVFDN LNDLQAVRKS
       190        200        210        220        230        240
LMSAVKANSS QQDAVDAYTN LSSENLNGII ENAFEDPLNH VLDIREYDVP YHSRTLIDLN
       250        260        270        280        290        300
IRVGQWYTVS YHEGHVQISL LASRIERAEP TIMAFDIETT KLPLKFPDSS FDKIMMISYM
       310        320        330        340        350        360
IDGQGFLITN REIISQNIED FHYTPREEFE GPFIIFNEPD EVGLLHRFFK HIRSAKPSVI
       370        380        390        400        410        420
VTYNGDFFDW PFVDARAAFH GLNLTEETGF FRDAEDEYKS SYCSHMDAFR WVKRDSYLPQ
       430        440        450        460        470        480
GSQGLKAVTV SKLGYNPIEL DPELMTPYAS EKPQVLAQYS VSDAVATYFL YMKYVHPFIF
       490        500        510        520        530        540
SLCNIIPLNP DEVLRKGTGT LCETLLTVEA CTKNIILPNK HVDASQKFFD GHLLASETYV
       550        560        570        580        590        600
GGHVESLESG VFRSDLPTNF NMDPKVYEEL ILQLDKALDF SLTVENNVNV DEIENYEEVR
       610        620        630        640        650        660
DSILKKLSDL RDRPKRSEKP RIYHLDVASM YPNIMITNRL QPDSVKDESF CATCDLNVPN
       670        680        690        700        710        720
KTCDRRMVWA WRGEYYPAKK GEYHMIYSAL QSERFPGPTP FSPFRSFQEL SPSEQAAMVQ
       730        740        750        760        770        780
KRIADYSRKV YHRLYDNTVI ERETIICQKE NSFYIDTVKS FRDRRYDFKG LQKKWVKQLA
       790        800        810        820        830        840
AIKEKGGLAE IEEAKKMVVL YDSLQLAHKV ILNSFYGYVM RKGSRWYSIE MAGITCLTGA
       850        860        870        880        890        900
TIIQMARQIV ERAGRPLELD TDGIWCILPE SFPENFEFKK KSGGKVFISY PCVMLNHLVH
       910        920        930        940        950        960
EKFTNHQYSA LKDPEKLVYE TTSENSIFFE VDGPYRAMIL PASTEEGKNL KKRYAVFNFD
       970        980        990       1000       1010       1020
GSLAELKGFE VKRRGELKLI KDFQSQIFKV FLKGDSLEEC YQEVAYVADT WLEILFTKGS
      1030       1040       1050       1060       1070       1080
NLTDDELIEL ISENRSMSKA LSEYGSQKST SITTARRLAD FLGDQMTKDK GLACRFIISA
      1090       1100       1110       1120       1130       1140
SPKGRPVAER AVPVAIFFAE ESVKRHFLRL WLKDNGLYDV DIRDIIDWDY YLKRLGSVVQ
      1150       1160       1170       1180       1190       1200
KLISIPAALQ RISNPVTRFP LPDWLQKRVA VLNSKYQQKK IDSIFSLAPT NPSTINNTKV
      1210       1220       1230       1240       1250       1260
TDIEDLGSVT HKDKRIVARV TKRKLLQQSG NSEAPVSFEV KPVSFMDGYS NWLKYAKKKW
      1270       1280       1290       1300       1310       1320
KYQKQVKLRR RHLIGFQSRQ FTNVLQSSAE VMFENLWHIL QIRETDVPGI LHAWVIIRNR
      1330       1340       1350       1360       1370       1380
LTSIRFIVNR KFFVCFKDET LPNVEIEGCL IEKSNAILPH GSTSDKLFLL EIPEKSYLTE
      1390       1400       1410       1420       1430       1440
KVSISMIFAH PSVSGIYETR IEPIERLILE MGSRKRFNNS VPGALGKGFE FGFESKMFTD
      1450       1460       1470       1480       1490       1500
PSDNDVSYLD GVEMNYLYAF HFSISNRFVF SLFMPHLKKV EAIIYDKLPG SDMSFPSISK
      1510       1520       1530       1540       1550       1560
IYEELRSKFD NLIKESSIEY PDTLSCNVIF SGNERKAYKL IDEKLLQYFS TKTKNSLLII
      1570       1580       1590       1600       1610       1620
ESSLPHILKA NVKQIEELPY IMIPRLESNI QSLSWKQHIA TKMIQHFLAI GSWLFHRIQL
      1630       1640       1650       1660       1670       1680
SRFSDIPLCN FESDDIQYSI DVVYSRKLKE HNIILWWNKG PTPDLGGIEK DSILQIASPK
      1690       1700       1710       1720       1730       1740
DPLEVNNPGA YSNACVDISL SNLALCSILN SALINDIEGI GDMAALNDNY MTAINDDLEE
      1750       1760       1770       1780       1790       1800
KLGIHDNIGL THSLPVLKAL VKTWWNEAAS GNNLADLIIQ HLARWISSSK SYLYSPLLSS
      1810       1820       1830       1840       1850       1860
HVEVIMRKTF LQLLSEIKRL GAHIIHASAN KILIKTSKLI VQNAVTYSNY LLKSIKTLPL
      1870       1880       1890       1900       1910       1920
FHFLDLNVTE YWDYLLWMDS VNYGGKMVAA NFSATNEEPQ TVVSWHIKSH LPPIIQPEFQ
      1930       1940       1950       1960       1970       1980
SWIVEFIEEV YKQKLEKSNT KVGFVRVKNN NADEDSEIVG SGILKSKLIH PLKRKVAQVR
      1990       2000       2010       2020       2030       2040
RCFQELQLDE NTREDLKFPK LPGSFLNYTD GALELVKSIC AVFELSHDLN LEVRFLKKSL
      2050       2060       2070       2080       2090       2100
LSLLQIQEFS TQAVFRYPSR RLSLDQIPCK QCGVHQDFDL CLHEHLWPTR DDMGTLVFSD
      2110       2120       2130       2140       2150       2160
GWSCSSCNLV YDRWVFEETL VDNLYHQLTL YQLQDLICSK CKTVKQWSLK ERCSCSGEWV
      2170       2180       2190
LQLSPTKFRE MLNVYQSVAD FYEFSILQNS VQSILSVLN  

Encoded by cdc20 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgcccttaa aaacagctcg aggagcatcc aaatatcagt ttaggaaatt taatggtaac
        70         80         90        100        110        120
tacaatggaa aaagtaaatc gaacggtagg acgtttgcaa aatcaaccga ggaagttggc
       130        140        150        160        170        180
ttcaatgatc ctatgaaaat tgtctacaaa aagaatgaga ttgatcgaat gatgggtttt
       190        200        210        220        230        240
gatagctatg aaggtggaca accacgagaa gcttggcttc tcaacgttca tccaacagta
       250        260        270        280        290        300
atcgaaagca ccaaaggcaa ttctaccctc agtgccgttg acttttactt cattcaagac
       310        320        330        340        350        360
gatggtgaca ctttccggtg taccattcca tactctcctt acttctacat tgctgctcga
       370        380        390        400        410        420
gaaggtaaag aagctttggt tgacgattat ttaaaaaaaa aatttgtggg cttaattaaa
       430        440        450        460        470        480
tctactacgc gtatctttaa agaagattta cagctaaaaa accacatagt gggttaccaa
       490        500        510        520        530        540
aagttgtata taaagttggt ttttgataac ctgaatgacc ttcaggctgt caggaagtct
       550        560        570        580        590        600
ttgatgtctg ctgtgaaagc taattcttcc caacaagatg ccgttgatgc atacactaac
       610        620        630        640        650        660
ttgtcttcgg agaatttaaa cgggattata gaaaacgcat ttgaagatcc tttaaatcat
       670        680        690        700        710        720
gttttagata tccgtgagta cgatgttccg tatcattctc gtacacttat tgatttgaat
       730        740        750        760        770        780
attcgagtcg gacaatggta tactgtttca tatcatgaag gccatgttca aatatccctt
       790        800        810        820        830        840
ttagcttccc gaatcgagcg tgcagaacct actataatgg cttttgatat tgaaaccact
       850        860        870        880        890        900
aagctgccat tgaagtttcc tgatagctcg ttcgataaaa taatgatgat atcttatatg
       910        920        930        940        950        960
attgatggcc aaggattttt aattaccaat agagaaatta tttcccagaa tattgaagat
       970        980        990       1000       1010       1020
tttcattata ctccgaggga ggaatttgag ggcccattta ttatttttaa tgagcctgat
      1030       1040       1050       1060       1070       1080
gaagttggcc tacttcatcg attctttaaa catataaggt ctgcaaagcc ttcagtaata
      1090       1100       1110       1120       1130       1140
gttacataca atggtgactt ctttgactgg ccatttgtag acgcacgtgc tgcatttcac
      1150       1160       1170       1180       1190       1200
ggattgaatt taacagaaga aactggtttc ttcagggacg cagaggatga atataagtct
      1210       1220       1230       1240       1250       1260
tcttattgta gtcatatgga tgccttccgg tgggtaaaga gagatagtta tttacctcaa
      1270       1280       1290       1300       1310       1320
ggaagtcaag gtctcaaagc tgtcactgtc agtaaattag gttataatcc tatcgaacta
      1330       1340       1350       1360       1370       1380
gatccagaat tgatgactcc ttatgcaagt gaaaaacctc aagttcttgc tcaatattca
      1390       1400       1410       1420       1430       1440
gtttcagatg ctgttgctac ttattttctt tacatgaaat atgtgcatcc tttcattttt
      1450       1460       1470       1480       1490       1500
tctctttgta acattatccc attaaatcct gatgaagttt tacgtaaagg cacgggtacg
      1510       1520       1530       1540       1550       1560
ttgtgtgaaa cgcttttaac tgttgaggct tgtacaaaaa atattattct tccgaataaa
      1570       1580       1590       1600       1610       1620
catgttgatg ctagtcaaaa atttttcgac ggtcatttac ttgcaagtga gacttatgtt
      1630       1640       1650       1660       1670       1680
ggaggacatg ttgaaagtct tgaaagtggt gtttttagaa gcgacttgcc gactaatttc
      1690       1700       1710       1720       1730       1740
aacatggatc caaaagttta tgaagaacta attttacagt tggacaaagc cttagatttt
      1750       1760       1770       1780       1790       1800
tctttaacag ttgaaaacaa cgtcaatgtt gatgaaatcg aaaattatga agaggttaga
      1810       1820       1830       1840       1850       1860
gacagcatat taaagaaact aagtgacctt cgtgatcgac caaaaaggtc ggagaagcca
      1870       1880       1890       1900       1910       1920
aggatttacc atcttgatgt cgcctcaatg tacccaaata ttatgattac caaccggtta
      1930       1940       1950       1960       1970       1980
cagccagatt cagtaaaaga tgaatcgttt tgtgcaacat gcgatcttaa tgtgcccaat
      1990       2000       2010       2020       2030       2040
aagacatgtg atcgtcggat ggtatgggca tggagagggg agtattaccc tgctaaaaaa
      2050       2060       2070       2080       2090       2100
ggtgaatatc atatgatata ttctgcttta caatctgagc gttttccagg ccctacccct
      2110       2120       2130       2140       2150       2160
ttctcacctt ttaggtcatt tcaagagctt tctccctcag aacaagctgc tatggtgcaa
      2170       2180       2190       2200       2210       2220
aagcgcattg cggattacag ccgtaaagtg tatcaccgtc tatatgataa taccgttatc
      2230       2240       2250       2260       2270       2280
gaaagggaaa ctataatttg tcaaaaggaa aactcatttt atattgatac ggtaaaaagc
      2290       2300       2310       2320       2330       2340
tttagggatc gccgttatga ctttaaagga ttgcaaaaaa aatgggtcaa acaacttgct
      2350       2360       2370       2380       2390       2400
gctataaagg aaaaaggagg acttgctgaa atagaggagg ccaaaaagat ggtcgtactc
      2410       2420       2430       2440       2450       2460
tacgattctt tacagttagc tcacaaagtt attttaaact ctttctatgg atatgtcatg
      2470       2480       2490       2500       2510       2520
cgaaaaggct cccgttggta ttcgattgaa atggctggta tcacatgttt gacaggcgct
      2530       2540       2550       2560       2570       2580
acgattattc agatggctcg tcaaatagtt gaacgtgcag gtaggccatt ggaacttgac
      2590       2600       2610       2620       2630       2640
acagatggta tttggtgtat tcttccagaa tcgtttcctg aaaactttga atttaaaaag
      2650       2660       2670       2680       2690       2700
aaatccggag gaaaggtttt tatctcttat ccatgcgtta tgttaaatca cctggttcat
      2710       2720       2730       2740       2750       2760
gaaaagttca ccaatcatca atattctgcc ttaaaggacc cagagaaatt ggtgtatgaa
      2770       2780       2790       2800       2810       2820
acaactagtg aaaacagcat tttttttgag gttgatggtc cttatagagc tatgattttg
      2830       2840       2850       2860       2870       2880
cctgcttcaa cggaagaagg taaaaactta aaaaagcgtt atgccgtttt caatttcgat
      2890       2900       2910       2920       2930       2940
ggtagtttag ctgaacttaa aggctttgag gtgaaaagaa gaggagaatt gaagctcatt
      2950       2960       2970       2980       2990       3000
aaggattttc aatctcagat atttaaagtt tttttgaaag gtgattcttt agaggaatgc
      3010       3020       3030       3040       3050       3060
tatcaagaag ttgcctatgt tgctgacact tggttagaga ttctattcac caaaggctct
      3070       3080       3090       3100       3110       3120
aacctaacag atgatgaatt aattgaactg atttctgaga atcgtagtat gtctaaagct
      3130       3140       3150       3160       3170       3180
ttgtctgaat acggaagcca aaaatcgaca tccattacta cagccaggcg actggctgac
      3190       3200       3210       3220       3230       3240
tttttgggtg atcaaatgac caaagacaaa ggtctagcat gtcgttttat tatttccgca
      3250       3260       3270       3280       3290       3300
agtccaaaag gaaggccagt tgcagaaagg gcagtaccgg tagctatttt ctttgctgaa
      3310       3320       3330       3340       3350       3360
gaatctgtta agcgacattt tcttaggctc tggttgaaag ataatggtct atatgatgtt
      3370       3380       3390       3400       3410       3420
gatattagag acattattga ttgggattat tatttgaaac gtctaggatc agtagtacaa
      3430       3440       3450       3460       3470       3480
aaactaatta gcatccctgc tgctctccaa aggatttcaa accccgttac ccgttttcca
      3490       3500       3510       3520       3530       3540
ttgccggact ggcttcaaaa acgagttgct gtcttgaatt ctaaatacca acagaaaaag
      3550       3560       3570       3580       3590       3600
atcgattcca ttttctcctt agcccctaca aatccatcca caataaacaa cacaaaagtt
      3610       3620       3630       3640       3650       3660
actgatattg aggatttagg aagtgtgact cacaaagata agcgtattgt cgctcgagtt
      3670       3680       3690       3700       3710       3720
accaagcgta aacttttaca acaatctggg aactcggaag cacctgtatc ttttgaagta
      3730       3740       3750       3760       3770       3780
aaacctgtat cctttatgga tggatattcg aattggctta agtatgctaa gaaaaagtgg
      3790       3800       3810       3820       3830       3840
aaatatcaga agcaggtcaa gcttcgaaga agacatttaa ttgggtttca atcaaggcaa
      3850       3860       3870       3880       3890       3900
ttcaccaatg ttttacaatc ttctgctgaa gttatgtttg aaaatttatg gcatatttta
      3910       3920       3930       3940       3950       3960
caaatacgag aaaccgatgt tcctggtatt ttacatgctt gggtaattat tcgtaatcgg
      3970       3980       3990       4000       4010       4020
ttgacctcga tacggttcat tgtgaataga aagttttttg tatgtttcaa agatgagact
      4030       4040       4050       4060       4070       4080
ttaccgaatg ttgaaattga gggatgctta attgaaaaaa gcaatgcgat attaccgcat
      4090       4100       4110       4120       4130       4140
ggaagcactt cggataagct ttttttactt gaaattccag aaaagagcta tttaacggaa
      4150       4160       4170       4180       4190       4200
aaggtatcaa tttctatgat ttttgcccat ccgtctgtta gtggaatata tgagactcgt
      4210       4220       4230       4240       4250       4260
atagaaccaa ttgaaagatt gatattagaa atgggatcca gaaaaaggtt taataattca
      4270       4280       4290       4300       4310       4320
gtacctggag cgttaggtaa aggcttcgaa tttggatttg aatctaaaat gttcactgac
      4330       4340       4350       4360       4370       4380
ccaagtgata acgatgtttc ctatcttgat ggagtagaga tgaactacct ttatgcattc
      4390       4400       4410       4420       4430       4440
catttttcca ttagtaatag gtttgttttt tcacttttta tgccacattt aaaaaaagtt
      4450       4460       4470       4480       4490       4500
gaggccataa tttatgacaa actgccaggt agtgatatgt ctttcccatc aatcagcaaa
      4510       4520       4530       4540       4550       4560
atttacgaag agctacggtc gaaatttgat aatttaatta aggaaagtag tatcgaatac
      4570       4580       4590       4600       4610       4620
cctgatactc tttcgtgtaa tgtcattttc tcgggaaacg aaaggaaagc gtacaaactg
      4630       4640       4650       4660       4670       4680
atagatgaaa agttgcttca atatttttca actaaaacta aaaatagtct gcttattatt
      4690       4700       4710       4720       4730       4740
gaaagttcac tccctcacat attgaaggca aatgtgaagc aaattgaaga gcttccgtat
      4750       4760       4770       4780       4790       4800
ataatgatac cacggcttga gagcaacata cagtctcttt cttggaaaca acacattgct
      4810       4820       4830       4840       4850       4860
acgaaaatga tccaacattt cttagctatt ggtagctggc ttttccatcg catacaactt
      4870       4880       4890       4900       4910       4920
tctcgcttct cagatatccc attatgcaac tttgaaagcg atgacattca gtacagtatc
      4930       4940       4950       4960       4970       4980
gatgttgttt actctagaaa gctgaaagaa cataatatta tcctttggtg gaataaaggc
      4990       5000       5010       5020       5030       5040
ccaactccag acttaggtgg tattgagaag gatagtattc tgcagattgc cagtcccaaa
      5050       5060       5070       5080       5090       5100
gatccactag aagttaacaa tcctggtgct tattcaaatg cttgtgttga catttctctt
      5110       5120       5130       5140       5150       5160
tccaaccttg cactttgtag cattctcaat tctgctctca taaatgacat agaaggtatt
      5170       5180       5190       5200       5210       5220
ggcgacatgg cagctttgaa tgataattac atgaccgcca taaatgatga tctggaggaa
      5230       5240       5250       5260       5270       5280
aagttgggaa tacatgataa tattggactg acacattcat tgccggtgtt gaaggcgttg
      5290       5300       5310       5320       5330       5340
gttaaaactt ggtggaacga agctgcatcc ggtaataatc tcgctgatct tataattcaa
      5350       5360       5370       5380       5390       5400
catttagccc gatggatttc ttcatcaaaa tcttatctgt acagtccttt actctcctcg
      5410       5420       5430       5440       5450       5460
cacgtggaag ttataatgag aaaaactttt ttacaacttc tctctgagat aaaacgcctt
      5470       5480       5490       5500       5510       5520
ggagcacata tcatacacgc ttctgctaat aaaatattaa tcaaaacgag caaattaatc
      5530       5540       5550       5560       5570       5580
gtccagaacg ctgtcactta ttcaaattat ttactcaaat ccattaagac gttaccacta
      5590       5600       5610       5620       5630       5640
tttcactttt tggatctaaa tgtcacggaa tactgggatt atcttttatg gatggattcc
      5650       5660       5670       5680       5690       5700
gttaattatg gaggaaaaat ggtggcagca aatttttcag ctacaaatga agaaccacag
      5710       5720       5730       5740       5750       5760
acagttgttt catggcacat taaaagtcat ttacctccaa tcattcagcc cgaatttcag
      5770       5780       5790       5800       5810       5820
agttggattg ttgagtttat tgaagaggtt tataagcaaa aattagaaaa gtctaataca
      5830       5840       5850       5860       5870       5880
aaagttgggt ttgttcgcgt gaaaaacaac aatgctgatg aggactctga aatagttgga
      5890       5900       5910       5920       5930       5940
tcgggaattt taaaaagtaa gttgatacat cctcttaaac ggaaagttgc tcaagtaagg
      5950       5960       5970       5980       5990       6000
agatgttttc aagagcttca gcttgatgaa aataccagag aagatcttaa atttccaaag
      6010       6020       6030       6040       6050       6060
ttgccaggtt cttttcttaa ctatactgat ggcgctctag aattggttaa aagcatctgt
      6070       6080       6090       6100       6110       6120
gctgtttttg aactctccca tgatctcaat ttggaggtcc gttttttaaa aaagagttta
      6130       6140       6150       6160       6170       6180
ttgtcacttt tacaaattca agagttttcc actcaggcgg tatttcgata tcctagtcgt
      6190       6200       6210       6220       6230       6240
cgactttcac ttgatcaaat accctgtaag cagtgtggcg tccatcagga ttttgacctt
      6250       6260       6270       6280       6290       6300
tgtttacatg agcatctatg gcctactcgc gatgacatgg ggaccttggt gttttctgac
      6310       6320       6330       6340       6350       6360
ggatggtctt gttccagctg taacttagtt tacgatcgat gggtgtttga ggaaactttg
      6370       6380       6390       6400       6410       6420
gtggataact tataccatca attgacatta tatcaactgc aagatttgat ttgttctaaa
      6430       6440       6450       6460       6470       6480
tgtaagacag ttaagcaatg gtcattaaag gaacgctgtt catgcagcgg agaatgggta
      6490       6500       6510       6520       6530       6540
ttacagcttt cacctacaaa gtttcgtgaa atgttaaacg tttatcaatc tgttgctgat
      6550       6560       6570       6580       6590       6600
ttttacgagt tttctatatt gcaaaattct gttcagtcca tactttctgt gctgaactaa

Last modification date: Oct. 2, 2011