Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA polymerase subunit delta-2


DESCRIPTION:
Required for replication of the leading DNA strand and for completion of lagging strand synthesis. It is essential for cell cycle progression.

STRUCTURE SIMILARITY:
Belongs to the DNA polymerase delta/II small subunit family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MVEVRHSIPC EETKRLELSL SQQTYSQQYA SIYFARLTAL RPRITEAASK KWPDKQRLER
        70         80         90        100        110        120
VLDVKSDEDC WVVATAYMTT ALKPNVMNDV TQLHTIVTTT EESPYVSPED AASGDIEYAL
       130        140        150        160        170        180
EDDYGRIDCS GSFLYDAGVV TGVVLAVLGH EDEQGRFVVV DVCFPGIFSH SIPMTTDESQ
       190        200        210        220        230        240
AQPEYIAAVS GLGLSNDGIE GIQVHQLVDF LRGTLPHVSS FSPSSIKRLI ILGNCLAPSI
       250        260        270        280        290        300
EIADSASASV PIGKKKVKRY GYDTSAYNPN PTFQLDNFLD QVCSSIDVTL MPGPYDYSST
       310        320        330        340        350        360
ILPQQPLHPA LLTKSKVWLG SSLQTVTNPT WLSLGNHFVL ATSGQNINDL RKYHPKKSSL
       370        380        390        400        410        420
QCMENTLLWN HITPTSPDTL WCYPFTDKDT FVMEEMPDLY LCGNQPKFGC KTVINEGNRI
       430        440        450        460
QLVSVPEFRK TGVLVLINMH TLNVEIIQFR PMSVKAETPI TS 

Encoded by cdc1 gene


Nucleic acid sequence

        10         20         30         40         50         60
atggttgaag tcagacattc aattccttgt gaagaaacta aacgcttgga gcttagttta
        70         80         90        100        110        120
agtcagcaaa cgtatagtca acagtacgcc agcatctatt tcgcccgact taccgctctt
       130        140        150        160        170        180
cgacccagaa tcacagaagc cgcttcaaaa aaatggccgg ataaacagcg attggaacgc
       190        200        210        220        230        240
gttttagatg ttaagtcaga tgaagactgt tgggttgtcg ctaccgctta tatgactaca
       250        260        270        280        290        300
gctcttaagc caaacgttat gaacgatgtc acacaacttc atacaattgt caccactact
       310        320        330        340        350        360
gaagaatctc cgtatgttag cccagaagat gctgcttcag gtgatataga atatgctctt
       370        380        390        400        410        420
gaggatgact atggccgtat agattgtagc ggaagctttt tgtatgacgc tggcgttgtt
       430        440        450        460        470        480
acaggagttg ttcttgcagt tttgggccat gaagatgaac aaggtcgttt cgttgtcgtt
       490        500        510        520        530        540
gacgtttgtt ttccaggcat cttctctcat tccattccaa tgactacaga tgaatcgcaa
       550        560        570        580        590        600
gctcaaccag agtacattgc ggcagtcagt ggcttaggtc tctcaaatga cggcatagaa
       610        620        630        640        650        660
ggcattcaag ttcatcagct tgtagatttc ctaagaggaa cacttccaca tgtctcttcc
       670        680        690        700        710        720
ttttcccctt cctccatcaa aaggctaatt attctcggaa attgcttagc accttctata
       730        740        750        760        770        780
gaaattgccg actccgcttc tgcgtccgtg cccattggca agaaaaaagt aaaaagatat
       790        800        810        820        830        840
ggctatgaca cgtctgctta caatccaaat cccaccttcc aactagataa ttttcttgat
       850        860        870        880        890        900
caagtgtgtt ccagcataga tgtcacttta atgcctggtc cttatgatta cagttcaact
       910        920        930        940        950        960
atccttcctc aacagccttt gcatcccgct ttacttacta aatcaaaagt ttggttggga
       970        980        990       1000       1010       1020
tcttctttac aaacagttac gaatcccact tggctttctc ttggcaatca ttttgtgttg
      1030       1040       1050       1060       1070       1080
gctactagcg gccaaaacat taatgatctc cgaaaatatc atcccaaaaa atcttcactt
      1090       1100       1110       1120       1130       1140
caatgcatgg aaaacacttt actatggaat catatcacac ctaccagccc tgatacctta
      1150       1160       1170       1180       1190       1200
tggtgctatc ctttcaccga caaagataca tttgtaatgg aggaaatgcc tgatctatat
      1210       1220       1230       1240       1250       1260
ctttgtggta atcaaccgaa atttggctgc aaaacagtca ttaatgaggg aaacagaata
      1270       1280       1290       1300       1310       1320
caattggttt ccgttcccga atttcgtaag actggtgtac ttgttctcat aaatatgcat
      1330       1340       1350       1360       1370       1380
acgctcaacg tagaaattat tcaattccgc cccatgtcag tcaaagcaga gactccaatt

acttcttaa     

Last modification date: Oct. 2, 2011