Mus musculus L. (mouse) [MMU]

FULL NAME: DNA-directed RNA polymerases I, II, and III subunit RPABC2


DESCRIPTION:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and togther with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).

STRUCTURE SIMILARITY:
Belongs to the archaeal rpoK/eukaryotic RPB6 RNA polymerase subunit family.


RELATED PATHWAY(S):
transcription


Amino acids sequence

        10         20         30         40         50         60
MSDNEDNFDG DDFDDVEEDE GLDDLENAEE EGQENVEILP SGERPQANQK RITTPYMTKY
        70         80         90        100        110        120
ERARVLGTRA LQIAMCAPVM VELEGETDPL LIAMKELKAR KIPIIIRRYL PDGSYEDWGV

DELIISD     

Encoded by Polr2f gene

FULL NAME: polymerase (RNA) II (DNA directed) polypeptide F


OTHER NAME(S):
1810060D16Rik


Nucleic acid sequence

        10         20         30         40         50         60
atgtcagaca acgaggacaa tttcgacggc gacgactttg atgacgttga ggaggacgaa
        70         80         90        100        110        120
ggacttgacg acttggaaaa tgctgaggag gagggccagg aaaatgtcga gattctccca
       130        140        150        160        170        180
tctggtgagc gaccacaggc caaccagaag cggatcacca ctccttacat gaccaagtat
       190        200        210        220        230        240
gagcgtgccc gagtgctggg cacccgggct cttcagatcg cgatgtgtgc cccggtgatg
       250        260        270        280        290        300
gtggagctgg agggggagac agaccctttg ctcatcgcca tgaaggaact caaggcgcgg
       310        320        330        340        350        360
aagatcccca tcatcattcg ccggtacctg ccagacggca gctatgagga ctggggcgtg
       370        380
gacgagctta tcatcagcga ctga   

Last modification date: Oct. 2, 2011