Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA polymerase delta catalytic subunit


DESCRIPTION:
This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction.

MISCELLANEOUS:
In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-B family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MTDRSSNEGV VLNKENYPFP RRNGSIHGEI TDVKRRRLSE RNGYGDKKGS SSKEKTSSFE
        70         80         90        100        110        120
DELAEYASQL DQDEIKSSKD QQWQRPALPA INPEKDDIYF QQIDSEEFTE GSVPSIRLFG
       130        140        150        160        170        180
VTDNGNSILV HVVGFLPYFY VKAPVGFRPE MLERFTQDLD ATCNGGVIDH CIIEMKENLY
       190        200        210        220        230        240
GFQGNEKSPF IKIFTTNPRI LSRARNVFER GEFNFEELFP VGVGVTTFES NTQYLLRFMI
       250        260        270        280        290        300
DCDVVGMNWI HLPASKYQFR YQNRVSNCQI EAWINYKDLI SLPAEGQWSK MAPLRIMSFD
       310        320        330        340        350        360
IECAGRKGVF PDPSIDPVIQ IASIVTQYGD STPFVRNVFC VDTCSQIVGT QVYEFQNQAE
       370        380        390        400        410        420
MLSSWSKFVR DVDPDVLIGY NICNFDIPYL LDRAKSLRIH NFPLLGRIHN FFSVAKETTF
       430        440        450        460        470        480
SSKAYGTRES KTTSIPGRLQ LDMLQVMQRD FKLRSYSLNA VCSQFLGEQK EDVHYSIITD
       490        500        510        520        530        540
LQNGTADSRR RLAIYCLKDA YLPQRLMDKL MCFVNYTEMA RVTGVPFNFL LARGQQIKVI
       550        560        570        580        590        600
SQLFRKALQH DLVVPNIRVN GTDEQYEGAT VIEPIKGYYD TPIATLDFSS LYPSIMQAHN
       610        620        630        640        650        660
LCYTTLLDSN TAELLKLKQD VDYSVTPNGD YFVKPHVRKG LLPIILADLL NARKKAKADL
       670        680        690        700        710        720
KKETDPFKKA VLDGRQLALK VSANSVYGFT GATNGRLPCL AISSSVTSYG RQMIEKTKDV
       730        740        750        760        770        780
VEKRYRIENG YSHDAVVIYG DTDSVMVKFG VKTLPEAMKL GEEAANYVSD QFPNPIKLEF
       790        800        810        820        830        840
EKVYFPYLLI SKKRYAGLFW TRTDTYDKMD SKGIETVRRD NCPLVSYVID TALRKMLIDQ
       850        860        870        880        890        900
DVEGAQLFTK KVISDLLQNK IDMSQLVITK ALSKTDYAAK MAHVELAERM RKRDAGSAPA
       910        920        930        940        950        960
IGDRVAYVII KGAQGDQFYM RSEDPIYVLE NNIPIDAKYY LENQLSKPLL RIFEPILGEK
       970        980        990       1000       1010       1020
ASSLLHGDHT RTISMAAPSV GGIMKFAVKV ETCLGCKAPI KKGKTALCEN CLNRSAELYQ
      1030       1040       1050       1060       1070       1080
RQVAQVNDLE VRFARLWTQC QRCQGSMHQD VICTSRDCPI FYMRIAEHKK LQQSVDLLKR

FDEMSW     

Encoded by cdc6 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgacagata ggtcttcaaa tgagggcgtc gtgttaaata aagaaaacta tccatttccc
        70         80         90        100        110        120
cgaagaaatg gttcaattca tggcgaaatt acagatgtca aacggcgacg tttaagcgaa
       130        140        150        160        170        180
agaaatggat atggtgataa aaagggctca tcctcaaaag aaaaaacttc atcttttgag
       190        200        210        220        230        240
gatgagctgg ctgaatacgc ttcacaattg gaccaagatg aaataaaatc ttcaaaagat
       250        260        270        280        290        300
cagcagtggc aacgaccagc tttacctgca ataaatcctg agaaggatga tatttatttt
       310        320        330        340        350        360
cagcaaatcg atagtgagga gttcacagaa ggatctgtac cttcaattcg tttgtttggt
       370        380        390        400        410        420
gttactgaca atggaaacag catccttgtt catgttgtgg gattccttcc gtacttttat
       430        440        450        460        470        480
gttaaagccc cggttggatt tcgacctgag atgctagaac gtttcacaca agatttagat
       490        500        510        520        530        540
gctacttgta atgggggtgt gatcgatcat tgcattatag agatgaagga aaatttatat
       550        560        570        580        590        600
ggatttcagg gaaatgaaaa atctccattc attaaaatct ttactactaa ccctcgtata
       610        620        630        640        650        660
ttatctcgag cacgaaatgt atttgaaaga ggagaattca acttcgaaga gcttttccct
       670        680        690        700        710        720
gttggtgtcg gtgtcactac ttttgagagc aatacgcaat atcttcttag attcatgatt
       730        740        750        760        770        780
gactgtgatg ttgttggtat gaattggatt catcttcctg cttcaaaata tcaatttcgt
       790        800        810        820        830        840
taccagaatc gagtttctaa ttgtcaaatt gaagcttgga ttaattacaa agacttgatc
       850        860        870        880        890        900
agtcttccag ctgaaggcca gtggtctaaa atggccccac tgaggatcat gagctttgat
       910        920        930        940        950        960
attgaatgcg caggtcgcaa aggcgttttt cctgatccct ctattgaccc tgtaattcaa
       970        980        990       1000       1010       1020
attgcaagta tagtaacgca gtatggagac tccactcctt ttgttcgtaa tgtcttttgt
      1030       1040       1050       1060       1070       1080
gttgatacat gctcacaaat cgttggaaca caagtatatg aatttcaaaa tcaggctgaa
      1090       1100       1110       1120       1130       1140
atgctttcaa gttggtcaaa atttgttcgt gatgttgacc cagatgtttt aattgggtac
      1150       1160       1170       1180       1190       1200
aacatctgca actttgatat cccttacctc ttggatcgag caaaaagctt acgcattcac
      1210       1220       1230       1240       1250       1260
aatttcccat tacttggccg tattcataat tttttttctg tcgcaaagga aaccacgttt
      1270       1280       1290       1300       1310       1320
tcaagtaaag catatggtac tcgtgaaagc aaaaccacta gtattcctgg gcgtttgcag
      1330       1340       1350       1360       1370       1380
cttgatatgt tacaagtaat gcagcgtgat tttaagcttc gatcttactc tttaaatgca
      1390       1400       1410       1420       1430       1440
gtctgctctc agtttctagg cgagcaaaaa gaagatgtac actattctat catcactgac
      1450       1460       1470       1480       1490       1500
ttgcaaaatg gcactgccga ttctagaaga cgtttagcta tttattgtct gaaagatgca
      1510       1520       1530       1540       1550       1560
tatttacccc aacgcttaat ggacaaatta atgtgttttg ttaactatac tgaaatggca
      1570       1580       1590       1600       1610       1620
agagtaacag gtgtaccgtt taattttctt cttgctagag gccaacagat taaagttatt
      1630       1640       1650       1660       1670       1680
tctcaattgt ttcgcaaagc tcttcaacat gacctagttg ttccaaatat acgtgtaaat
      1690       1700       1710       1720       1730       1740
ggaacagatg agcaatatga aggtgctaca gtcattgaac cgattaaagg atactatgat
      1750       1760       1770       1780       1790       1800
acccctattg caacactgga ttttagttca ctttatcctt cgattatgca agcccataat
      1810       1820       1830       1840       1850       1860
ttatgctata cgacattact tgactcaaat actgcagaat tattaaaact taagcaagat
      1870       1880       1890       1900       1910       1920
gttgactact cagtgactcc gaacggagat tatttcgtta aaccacatgt tcgtaaagga
      1930       1940       1950       1960       1970       1980
ctactcccta ttatcttagc tgatttactt aatgcacgta agaaagcaaa agcagatcta
      1990       2000       2010       2020       2030       2040
aaaaaggaaa cggacccatt caaaaaggct gttttggatg gtagacagct agctttaaaa
      2050       2060       2070       2080       2090       2100
gtaagtgcta attcagtata tggatttact ggtgctacca acggacgttt gccgtgttta
      2110       2120       2130       2140       2150       2160
gcaatttctt cttctgttac ctcttatggt cgacaaatga ttgaaaaaac caaggatgtt
      2170       2180       2190       2200       2210       2220
gtagaaaaga gatacagaat tgagaatgga tactctcacg atgcagttgt aatctatggt
      2230       2240       2250       2260       2270       2280
gacactgatt ctgttatggt taagtttggc gttaaaacgt tacctgaagc catgaaatta
      2290       2300       2310       2320       2330       2340
ggagaggaag cagctaatta tgtttcagac cagtttccga atcctattaa actggagttt
      2350       2360       2370       2380       2390       2400
gagaaagtgt actttccata tcttttaatt tccaaaaaac gttatgcagg attattttgg
      2410       2420       2430       2440       2450       2460
actcgtacag atacttatga taaaatggac tctaaaggaa tagaaactgt cagaagagat
      2470       2480       2490       2500       2510       2520
aactgtcctc tagtatctta tgtgattgac acagctttga gaaaaatgtt aattgatcag
      2530       2540       2550       2560       2570       2580
gatgtagagg gtgcacagtt gtttacaaaa aaagttattt ccgatttgtt acaaaacaaa
      2590       2600       2610       2620       2630       2640
attgatatgt cacaacttgt aatcacaaag gcattatcaa aaactgatta tgctgccaaa
      2650       2660       2670       2680       2690       2700
atggcacacg ttgaattggc tgagcgaatg cgtaaacgag atgctggctc cgccccagcc
      2710       2720       2730       2740       2750       2760
ataggagatc gcgttgcata cgttattatt aaaggtgcac aaggtgatca attttatatg
      2770       2780       2790       2800       2810       2820
aggtcggagg accctatata tgtattggaa aataacattc ctattgatgc aaaatattat
      2830       2840       2850       2860       2870       2880
ttggaaaatc aactctccaa acctttgctt agaatttttg agcctattct tggtgaaaaa
      2890       2900       2910       2920       2930       2940
gctagctctt tacttcatgg tgaccatact cggacgattt ccatggcagc ccccagtgtt
      2950       2960       2970       2980       2990       3000
ggaggaataa tgaaattcgc agtaaaggtt gagacctgtc ttggatgcaa agctcccata
      3010       3020       3030       3040       3050       3060
aaaaaaggta aaactgcttt atgtgagaat tgtctaaata gatcggcgga actgtatcaa
      3070       3080       3090       3100       3110       3120
cgtcaggttg ctcaagtgaa tgatttagaa gttcgttttg ctcgcttatg gactcaatgt
      3130       3140       3150       3160       3170       3180
cagcgatgcc aaggaagtat gcatcaagac gtcatttgta ccagtagaga ctgccccata
      3190       3200       3210       3220       3230       3240
ttttatatgc gaattgcaga acacaagaaa cttcagcaat ctgttgactt actgaaaaga
      3250       3260
tttgatgaaa tgtcctggtg a   

Last modification date: Oct. 2, 2011