Mus musculus L. (mouse) [MMU]

FULL NAME: DNA-directed RNA polymerase II subunit RPB9


DESCRIPTION:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).

STRUCTURE SIMILARITY:
Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
Contains 1 TFIIS-type zinc finger.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity).


RELATED PATHWAY(S):
transcription


Amino acids sequence

        10         20         30         40         50         60
MEPDGTYEPG FVGIRFCQEC NNMLYPKEDK ENRILLYACR NCDYQQEADN SCIYVNKITH
        70         80         90        100        110        120
EVDELTQIIA DVSQDPTLPR TEDHPCQKCG HKEAVFFQSH SARAEDAMRL YYVCTAPHCG

HRWTE     

Encoded by Polr2i gene

FULL NAME: polymerase (RNA) II (DNA directed) polypeptide I


OTHER NAME(S):
2810002B19Rik
MGC73656


Nucleic acid sequence

        10         20         30         40         50         60
atggaacccg acgggacgta cgagcctggc ttcgtgggta ttcggttctg ccaggaatgt
        70         80         90        100        110        120
aataacatgc tgtaccccaa ggaggacaag gaaaatcgca ttctgctgta cgcgtgccgg
       130        140        150        160        170        180
aattgcgatt accagcagga agccgacaac agctgcatct acgtcaacaa aatcacgcac
       190        200        210        220        230        240
gaagtggacg agctgaccca gatcatcgca gacgtgtccc aggaccccac gttgccccgg
       250        260        270        280        290        300
acggaggacc acccgtgcca gaagtgtggc cacaaggagg cagtgttctt tcagtcacac
       310        320        330        340        350        360
agtgcccgag ctgaggacgc catgcgcctg tactatgttt gcactgcccc acactgcggc
       370
caccgctgga ctgagtga    

Last modification date: Oct. 2, 2011