Homo sapiens L. (human) [HSA]

FULL NAME: DNA-directed RNA polymerases I, II, and III subunit RPABC2


DESCRIPTION:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II, and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPB6 is part of the clamp element and togther with parts of RPB1 and RPB2 forms a pocket to which the RPB4-RPB7 subcomplex binds (By similarity).

STRUCTURE SIMILARITY:
Belongs to the archaeal rpoK/eukaryotic RPB6 RNA polymerase subunit family.


RELATED PATHWAY(S):
transcription


Amino acids sequence

        10         20         30         40         50         60
MSDNEDNFDG DDFDDVEEDE GLDDLENAEE EGQENVEILP SGERPQANQK RITTPYMTKY
        70         80         90        100        110        120
ERARVLGTRA LQIAMCAPVM VELEGETDPL LIAMKELKAR KIPIIIRRYL PDGSYEDWGV

DELIITD     

Encoded by POLR2F gene

FULL NAME: polymerase (RNA) II (DNA directed) polypeptide F


OTHER NAME(S):
HRBP14.4
POLRF
RPABC2
RPB14.4
RPB6


DESCRIPTION:
This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes, that is also shared by the other two DNA-directed RNA polymerases. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgtcagaca acgaggacaa ttttgatggc gacgactttg atgatgtgga ggaggatgaa
        70         80         90        100        110        120
gggctagatg acttggagaa tgccgaagag gaaggccagg agaatgtcga gatcctcccc
       130        140        150        160        170        180
tctggggagc gaccgcaggc caaccagaag cgaatcacca caccatacat gaccaagtac
       190        200        210        220        230        240
gagcgagccc gcgtgctggg cacccgagcg ctccagattg cgatgtgtgc ccctgtgatg
       250        260        270        280        290        300
gtggagctgg agggggagac agatcctctg ctcattgcca tgaaggaact caaggcccga
       310        320        330        340        350        360
aagatcccca tcatcattcg ccgttacctg ccagatggga gctatgaaga ctggggggtg
       370        380
gacgagctca tcatcaccga ctga   

Last modification date: Oct. 2, 2011