Homo sapiens L. (human) [HSA]

FULL NAME: DNA-directed RNA polymerase II subunit RPB9


DESCRIPTION:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template (By similarity).

STRUCTURE SIMILARITY:
Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.
Contains 1 TFIIS-type zinc finger.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated upon DNA damage, probably by ATM or ATR.


RELATED PATHWAY(S):
transcription


Amino acids sequence

        10         20         30         40         50         60
MEPDGTYEPG FVGIRFCQEC NNMLYPKEDK ENRILLYACR NCDYQQEADN SCIYVNKITH
        70         80         90        100        110        120
EVDELTQIIA DVSQDPTLPR TEDHPCQKCG HKEAVFFQSH SARAEDAMRL YYVCTAPHCG

HRWTE     

Encoded by POLR2I gene

FULL NAME: polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa


OTHER NAME(S):
RPB9
hRPB14.5


DESCRIPTION:
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggagcccg acgggactta cgagccgggc ttcgtgggta ttcgcttctg ccaggaatgt
        70         80         90        100        110        120
aacaacatgc tgtaccccaa ggaagacaag gagaaccgca ttctgctcta cgcgtgccgg
       130        140        150        160        170        180
aactgtgatt accagcagga ggccgacaac agctgcatct atgtcaacaa gatcacgcac
       190        200        210        220        230        240
gaagtggacg aactgaccca gattatcgcc gacgtgtccc aggaccccac gttgccgcgg
       250        260        270        280        290        300
accgaggacc acccgtgcca aaagtgcggc cacaaggagg ctgtgttctt ccagtcacac
       310        320        330        340        350        360
agtgcgcggg ccgaggacgc catgcgcctt tactacgtgt gcacagcccc acactgcggc
       370
caccgctgga ccgagtga    

Last modification date: Oct. 2, 2011