Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA polymerase alpha subunit B


DESCRIPTION:
May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery (By similarity).

STRUCTURE SIMILARITY:
Belongs to the DNA polymerase alpha subunit B family.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated in a cell cycle-dependent manner (By similarity).


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MEFPIDDEEL LDERNKLLQI CNMDEQTMFY KWESWCLQRG NTPKLDLDTF KAFAKDMKFQ
        70         80         90        100        110        120
MERQVKATLK QNPERKSIKQ IPGMNIDSIL GLPVKTTASG DSLMQESKPS TETFELNSSD
       130        140        150        160        170        180
AGRVLEVLNK ELKIVTSKPS APSKLVIVAN FDLKAFNYRI MYQKLYDSSE VLDDRIELFS
       190        200        210        220        230        240
ALTCRKYNIS DEDLANPSEL TQEPVVVVGR IVVESTNLGG RLNQNSILLE SSRRLGAGVR
       250        260        270        280        290        300
VRLKVDDLPS YSIFPGQIVS VKGSNPSGNM FIAKEILPIP PLPFPSSSKQ EHATFVANTN
       310        320        330        340        350        360
NQPISIYIAS GPWSLRDDLS FSPLKSMISY VNKNPVDLVI LCGPFLDINH ILIRTGNITG
       370        380        390        400        410        420
TSATSLEELF KERVTPILSQ LTCPCILIPH INDAASDHPA WPQDAFNRVA LGLPSNFKCF
       430        440        450        460        470        480
PNPCMFSIND VVFGVSTNDI LLHTSREELF RLPSHGNLFA RLVSHVLHQR HFYPLFPGGS
       490        500        510        520        530        540
LEKCNPSNLD IAHLKLGEFL NTMPDILILP SDLRYFVKNV ENVVSLNPGK ATKGINLGTF
       550        560        570
AKLTIAPLEL GDNGSSNHYS HRVWLRTKAE ILKL  

Encoded by spb70 gene


Nucleic acid sequence

        10         20         30         40         50         60
atggaatttc ctatcgatga tgaggaattg ctagatgagc gaaataaact tctccaaatt
        70         80         90        100        110        120
tgcaatatgg acgagcaaac aatgttctac aagtgggagt cctggtgttt gcaacgagga
       130        140        150        160        170        180
aatacaccaa aactcgacct tgacacattc aaggcctttg ctaaagacat gaaatttcaa
       190        200        210        220        230        240
atggagaggc aggtaaaagc cacacttaaa cagaatcctg aaagaaaatc gataaagcaa
       250        260        270        280        290        300
atcccgggaa tgaatattga tagcatacta ggtctaccag tgaagaccac cgcatcaggc
       310        320        330        340        350        360
gactcgttga tgcaagagtc taaaccatct accgaaactt tcgaattgaa ttccagtgac
       370        380        390        400        410        420
gctggaaggg ttttggaagt tttaaataaa gaattaaaaa ttgtaacttc aaaaccttca
       430        440        450        460        470        480
gctccatcca agctggttat cgtagcgaat tttgatctca aggcatttaa ttacaggatc
       490        500        510        520        530        540
atgtatcaaa agctttatga ttcttctgaa gttctggatg atcgcattga gctttttagt
       550        560        570        580        590        600
gcattaactt gcagaaaata caacataagt gatgaagatt tggcaaatcc tagcgaactt
       610        620        630        640        650        660
actcaagaac ccgttgtagt tgtaggacga attgttgtcg aaagtaccaa tttaggtgga
       670        680        690        700        710        720
agactcaacc aaaatagcat tttacttgaa agttcaagac gtctaggcgc tggtgttcga
       730        740        750        760        770        780
gttcgtttga aggtggatga tctaccaagt tactcaatat ttcctggtca aattgtttca
       790        800        810        820        830        840
gttaaaggat ccaatcctag cggtaacatg tttatcgcca aggaaatcct tcctatacct
       850        860        870        880        890        900
cctttgccgt tcccaagttc atctaaacag gagcacgcta cctttgttgc taatacaaat
       910        920        930        940        950        960
aatcagccaa tttctatata tattgcatct ggaccttggt ctctccgtga tgatctctct
       970        980        990       1000       1010       1020
ttttcccctt taaaatcaat gatttcatat gtaaataaaa atcctgttga cttggttatt
      1030       1040       1050       1060       1070       1080
ctatgtggtc cattcttgga tattaatcat atactaatac gtaccggaaa cattacagga
      1090       1100       1110       1120       1130       1140
acgtctgcga cttctttgga agagttgttt aaagagcgtg tcacacccat attaagccag
      1150       1160       1170       1180       1190       1200
ctaacttgtc cttgtatttt aattcctcac atcaatgatg ctgcttcaga tcatcctgca
      1210       1220       1230       1240       1250       1260
tggccacagg atgcatttaa tcgggtggcc ttaggtcttc catctaactt caaatgcttc
      1270       1280       1290       1300       1310       1320
ccgaatcctt gcatgttttc cattaatgat gtcgtctttg gtgtgtcaac caacgatata
      1330       1340       1350       1360       1370       1380
ctccttcaca catctagaga agagttattt cgtctacctt ctcatggtaa cttatttgca
      1390       1400       1410       1420       1430       1440
cgtttggttt ctcacgtact tcaccaaagg catttttatc ccttattccc tggaggttct
      1450       1460       1470       1480       1490       1500
cttgaaaagt gcaacccttc aaacttagat atcgcacatc ttaaacttgg tgaattccta
      1510       1520       1530       1540       1550       1560
aatactatgc cggacatact aattttacca agtgatttac gttatttcgt aaagaacgtt
      1570       1580       1590       1600       1610       1620
gaaaacgttg tatcattgaa tcctggtaaa gcgaccaaag ggattaattt gggcactttt
      1630       1640       1650       1660       1670       1680
gcaaaattaa ctatcgcgcc attagagctc ggggataatg gttcttctaa tcattattca
      1690       1700       1710       1720
catcgtgtat ggcttcgaac caaggcagaa attttaaaac tatga 

Last modification date: Oct. 2, 2011