Homo sapiens L. (human) [HSA]

FULL NAME: DNA-directed RNA polymerase II subunit RPB7


DESCRIPTION:
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB7 is part of a subcomplex with RPB4 that binds to a pocket formed by RPB1, RPB2 and RPB6 at the base of the clamp element. The RBP4-RPB7 subcomplex seems to lock the clamp via RPB7 in the closed conformation thus preventing double stranded DNA to enter the active site cleft. The RPB4-RPB7 subcomplex binds single-stranded DNA and RNA (By similarity). Binds RNA.

STRUCTURE SIMILARITY:
Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.


RELATED PATHWAY(S):
transcription


Amino acids sequence

        10         20         30         40         50         60
MFYHISLEHE ILLHPRYFGP NLLNTVKQKL FTEVEGTCTG KYGFVIAVTT IDNIGAGVIQ
        70         80         90        100        110        120
PGRGFVLYPV KYKAIVFRPF KGEVVDAVVT QVNKVGLFTE IGPMSCFISR HSIPSEMEFD
       130        140        150        160        170
PNSNPPCYKT MDEDIVIQQD DEIRLKIVGT RVDKNDIFAI GSLMDDYLGL VS

Encoded by POLR2G gene

FULL NAME: polymerase (RNA) II (DNA directed) polypeptide G


OTHER NAME(S):
MGC138367
MGC138369
RPB19
RPB7
hRPB19
hsRPB7


DESCRIPTION:
This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation. [provided by RefSeq, Jan 2009]


Nucleic acid sequence

        10         20         30         40         50         60
atgttctacc atatctccct agagcacgaa atcctgctgc acccgcgcta cttcggcccc
        70         80         90        100        110        120
aacttgctca acacggtgaa gcagaagctc ttcaccgagg tggaggggac ctgcacaggg
       130        140        150        160        170        180
aagtatggct ttgtaattgc tgtcaccacc attgacaata ttggtgctgg tgtgatccag
       190        200        210        220        230        240
ccaggccgag gctttgtcct ttatccagtt aagtacaagg ccattgtttt ccggccattt
       250        260        270        280        290        300
aaaggggagg tcgtggatgc tgttgtcact caggtcaaca aggttggact cttcacagaa
       310        320        330        340        350        360
attgggccca tgtcttgctt catctctcga cattccatcc cttcagagat ggagtttgat
       370        380        390        400        410        420
cctaactcca acccaccatg ttacaagaca atggatgagg atattgtgat tcagcaggac
       430        440        450        460        470        480
gatgagatcc gcttaaagat tgtggggacc cgtgtggaca agaatgacat ttttgctatt
       490        500        510
ggctccctga tggacgatta cttggggctt gtaagctga  

Last modification date: Oct. 2, 2011