Homo sapiens L. (human) [HSA]

FULL NAME: Actin, cytoplasmic 1


DESCRIPTION:
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

MISCELLANEOUS:
In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.


STRUCTURE SIMILARITY:
Belongs to the actin family.


POST-TRANSLATIONAL MODIFICATION:
ISGylated.


RELATED PATHWAY(S):
chromatin remodeling


RELATED DISEASE(S):
dystonia juvenile-onset (DYTJ)


Amino acids sequence

        10         20         30         40         50         60
MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS
        70         80         90        100        110        120
KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPL NPKANREKMT
       130        140        150        160        170        180
QIMFETFNTP AMYVAIQAVL SLYASGRTTG IVMDSGDGVT HTVPIYEGYA LPHAILRLDL
       190        200        210        220        230        240
AGRDLTDYLM KILTERGYSF TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY
       250        260        270        280        290        300
ELPDGQVITI GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS
       310        320        330        340        350        360
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS TFQQMWISKQ
       370
EYDESGPSIV HRKCF    

Encoded by ACTB gene

FULL NAME: actin, beta


OTHER NAME(S):
PS1TP5BP1


DESCRIPTION:
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggatgatg atatcgccgc gctcgtcgtc gacaacggct ccggcatgtg caaggccggc
        70         80         90        100        110        120
ttcgcgggcg acgatgcccc ccgggccgtc ttcccctcca tcgtggggcg ccccaggcac
       130        140        150        160        170        180
cagggcgtga tggtgggcat gggtcagaag gattcctatg tgggcgacga ggcccagagc
       190        200        210        220        230        240
aagagaggca tcctcaccct gaagtacccc atcgagcacg gcatcgtcac caactgggac
       250        260        270        280        290        300
gacatggaga aaatctggca ccacaccttc tacaatgagc tgcgtgtggc tcccgaggag
       310        320        330        340        350        360
caccccgtgc tgctgaccga ggcccccctg aaccccaagg ccaaccgcga gaagatgacc
       370        380        390        400        410        420
cagatcatgt ttgagacctt caacacccca gccatgtacg ttgctatcca ggctgtgcta
       430        440        450        460        470        480
tccctgtacg cctctggccg taccactggc atcgtgatgg actccggtga cggggtcacc
       490        500        510        520        530        540
cacactgtgc ccatctacga ggggtatgcc ctcccccatg ccatcctgcg tctggacctg
       550        560        570        580        590        600
gctggccggg acctgactga ctacctcatg aagatcctca ccgagcgcgg ctacagcttc
       610        620        630        640        650        660
accaccacgg ccgagcggga aatcgtgcgt gacattaagg agaagctgtg ctacgtcgcc
       670        680        690        700        710        720
ctggacttcg agcaagagat ggccacggct gcttccagct cctccctgga gaagagctac
       730        740        750        760        770        780
gagctgcctg acggccaggt catcaccatt ggcaatgagc ggttccgctg ccctgaggca
       790        800        810        820        830        840
ctcttccagc cttccttcct gggcatggag tcctgtggca tccacgaaac taccttcaac
       850        860        870        880        890        900
tccatcatga agtgtgacgt ggacatccgc aaagacctgt acgccaacac agtgctgtct
       910        920        930        940        950        960
ggcggcacca ccatgtaccc tggcattgcc gacaggatgc agaaggagat cactgccctg
       970        980        990       1000       1010       1020
gcacccagca caatgaagat caagatcatt gctcctcctg agcgcaagta ctccgtgtgg
      1030       1040       1050       1060       1070       1080
atcggcggct ccatcctggc ctcgctgtcc accttccagc agatgtggat cagcaagcag
      1090       1100       1110       1120
gagtatgacg agtccggccc ctccatcgtc caccgcaaat gcttctag 

Last modification date: Oct. 2, 2011