Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: Ribonuclease H


DESCRIPTION:
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids (By similarity).

STRUCTURE SIMILARITY:
Contains 1 RNase H domain.
Belongs to the RNase H family.


CATALYTIC ACTIVITY:
Endonucleolytic cleavage to 5'-phosphomonoester.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MGGNKRAYYA VARGRNTGIY STWDEASDQV KGYGGNRYKK FDSYEAAQEF CRTEGSRYSS
        70         80         90        100        110        120
SSGPYRRSTT SYGYSPYSSS SSNYSARHSD KYRKKISRSY STEKDIEIFS NDTHEKSIAC
       130        140        150        160        170        180
SDRQVVYADG SSLRNGKKGA VAGCGVFFGN DDPRNISVPL AGEEQTNNRA ELQAIILALE
       190        200        210        220        230        240
NTSGDLTIRS DSNYSIKSLT TWLPKWKKND FKTSNSQPVK NLDLINRASD LMSDRNVSLE
       250        260
YVKGHSTDYG NQQADMLARR GASE   

Encoded by rnh1 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgggtggaa ataagcgtgc atactatgca gtagcgcgtg gtcgaaatac tggtatatat
        70         80         90        100        110        120
agtacatggg atgaggcgtc ggatcaggtg aaaggttatg gaggtaatcg ctacaagaaa
       130        140        150        160        170        180
tttgacagct atgaggctgc tcaggaattt tgcaggaccg aaggaagtcg ctactcctcg
       190        200        210        220        230        240
tcttctggcc catatcgccg cagtacaaca agttatgggt actctccata ttcttctagt
       250        260        270        280        290        300
tcctcaaatt actctgctag acactccgat aaatatagaa agaaaatttc tagaagttat
       310        320        330        340        350        360
agtaccgaaa aagatattga aatattttcg aatgacactc atgaaaaatc aattgcgtgc
       370        380        390        400        410        420
tcggatcgac aggtcgtcta tgctgacggt tctagtttgc gaaatgggaa aaaaggagct
       430        440        450        460        470        480
gttgctggct gtggagtttt tttcggaaat gatgacccaa gaaatatttc agtaccgttg
       490        500        510        520        530        540
gctggggaag agcaaaccaa caatcgtgcg gaattgcaag ccataatcct agcccttgaa
       550        560        570        580        590        600
aatacatctg gcgatttgac catccgctct gacagcaatt attccattaa gtcactaacc
       610        620        630        640        650        660
acatggctgc ctaaatggaa gaaaaatgac tttaagacta gcaattcaca acctgtaaaa
       670        680        690        700        710        720
aatttggatt tgatcaaccg cgcttcagat ttgatgagtg acagaaatgt ttcgctagag
       730        740        750        760        770        780
tacgtgaaag gacacagtac cgattacggt aatcaacaag ccgatatgct tgctcggcga
       790
ggagcttctg agtaa    

Last modification date: Oct. 2, 2011