Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: DNA replication ATP-dependent helicase DNA2


DESCRIPTION:
Required for DNA replication; has 3' to 5' ATP-dependent DNA helicase activity specific for forked substrates.

STRUCTURE SIMILARITY:
Belongs to the DNA2/NAM7 helicase family.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MPGTPQKNKR SASISVSPAK KTEEKEIIQN DSKAILSKQT KRKKKYAFAP INNLNGKNTK
        70         80         90        100        110        120
VSNASVLKSI AVSQVRNTSR TKDINKAVSK SVKQLPNSQV KPKREMSNLS RHHDFTQDED
       130        140        150        160        170        180
GPMEEVIWKY SPLQRDMSDK TTSAAEYSDD YEDVQNPSST PIVPNRLKTV LSFTNIQVPN
       190        200        210        220        230        240
ADVNQLIQEN GNEQVRPKPA EISTRESLRN IDDILDDIEG DLTIKPTITK FSDLPSSPIK
       250        260        270        280        290        300
APNVEKKAEV NAEEVDKMDS TGDSNDGDDS LIDILTQKYV EKRKSESQIT IQGNTNQKSG
       310        320        330        340        350        360
AQESCGKNDN TKSRGEIEDH ENVDNQAKTG NAFYENEEDS NCQRIKKNEK IEYNSSDEFS
       370        380        390        400        410        420
DDSLIELLNE TQTQVEPNTI EQDLDKVEKM VSDDLRIATD STLSAYALRA KSGAPRDGVV
       430        440        450        460        470        480
RLVIVSLRSV ELPKIGTQKI LECIDGKGEQ SSVVVRHPWV YLEFEVGDVI HIIEGKNIEN
       490        500        510        520        530        540
KRLLSDDKNP KTQLANDNLL VLNPDVLFSA TSVGSSVGCL RRSILQMQFQ DPRGEPSLVM
       550        560        570        580        590        600
TLGNIVHELL QDSIKYKLSH NKISMEIIIQ KLDSLLETYS FSIIICNEEI QYVKELVMKE
       610        620        630        640        650        660
HAENILYFVN KFVSKSNYGC YTSISGTRRT QPISISNVID IEENIWSPIY GLKGFLDATV
       670        680        690        700        710        720
EANVENNKKH IVPLEVKTGK SRSVSYEVQG LIYTLLLNDR YEIPIEFFLL YFTRDKNMTK
       730        740        750        760        770        780
FPSVLHSIKH ILMSRNRMSM NFKHQLQEVF GQAQSRFELP PLLRDSSCDS CFIKESCMVL
       790        800        810        820        830        840
NKLLEDGTPE ESGLVEGEFE ILTNHLSQNL ANYKEFFTKY NDLITKEESS ITCVNKELFL
       850        860        870        880        890        900
LDGSTRESRS GRCLSGLVVS EVVEHEKTEG AYIYCFSRRR NDNNSQSMLS SQIAANDFVI
       910        920        930        940        950        960
ISDEEGHFCL CQGRVQFINP AKIGISVKRK LLNNRLLDKE KGVTTIQSVV ESELEQSSLI
       970        980        990       1000       1010       1020
ATQNLVTYRI DKNDIQQSLS LARFNLLSLF LPAVSPGVDI VDERSKLCRK TKRSDGGNEI
      1030       1040       1050       1060       1070       1080
LRSLLVDNRA PKFRDANDDP VIPYKLSKDT TLNLNQKEAI DKVMRAEDYA LILGMPGTGK
      1090       1100       1110       1120       1130       1140
TTVIAEIIKI LVSEGKRVLL TSYTHSAVDN ILIKLRNTNI SIMRLGMKHK VHPDTQKYVP
      1150       1160       1170       1180       1190       1200
NYASVKSYND YLSKINSTSV VATTCLGIND ILFTLNEKDF DYVILDEASQ ISMPVALGPL
      1210       1220       1230       1240       1250       1260
RYGNRFIMVG DHYQLPPLVK NDAARLGGLE ESLFKTFCEK HPESVAELTL QYRMCGDIVT
      1270       1280       1290       1300       1310       1320
LSNFLIYDNK LKCGNNEVFA QSLELPMPEA LSRYRNESAN SKQWLEDILE PTRKVVFLNY
      1330       1340       1350       1360       1370       1380
DNCPDIIEQS EKDNITNHGE AELTLQCVEG MLLSGVPCED IGVMTLYRAQ LRLLKKIFNK
      1390       1400       1410       1420       1430       1440
NVYDGLEILT ADQFQGRDKK CIIISMVRRN SQLNGGALLK ELRRVNVAMT RAKSKLIIIG
      1450       1460       1470       1480       1490       1500
SKSTIGSVPE IKSFVNLLEE RNWVYTMCKD ALYKYKFPDR SNAIDEARKG CGKRTGAKPI
      1510       1520
TSKSKFVSDK PIIKEILQEY ES   

Encoded by DNA2 gene


OTHER NAME(S):
WEB2


Nucleic acid sequence

        10         20         30         40         50         60
atgcccggaa cgccacagaa gaacaagagg tctgcgagta tatctgtttc acctgcgaag
        70         80         90        100        110        120
aagacagagg aaaaagaaat aatacaaaat gattcaaagg cgatattatc taagcaaact
       130        140        150        160        170        180
aagaggaaaa aaaagtatgc ttttgctcct ataaataact taaatgggaa gaacaccaag
       190        200        210        220        230        240
gtatccaatg caagtgtcct aaagtcaata gccgtttcac aagtacgaaa tacatcaaga
       250        260        270        280        290        300
acaaaagata taaacaaagc agttagcaag agcgtaaagc aattaccaaa ttcacaagtt
       310        320        330        340        350        360
aaaccgaaac gggaaatgtc taatttgagt aggcatcacg atttcactca agacgaggac
       370        380        390        400        410        420
ggccccatgg aagaagtaat atggaaatat tcacctttac aacgagatat gtccgacaaa
       430        440        450        460        470        480
acaacaagcg ctgccgaata ctctgatgac tacgaagatg tccaaaatcc ctcttctaca
       490        500        510        520        530        540
cctatagtcc ctaatcgact gaaaactgtt cttagtttca caaatatcca agtacccaac
       550        560        570        580        590        600
gctgacgtaa atcaactcat tcaagaaaat ggaaatgagc aagtgcgtcc taaaccagca
       610        620        630        640        650        660
gaaatatcta ccagggagtc tctccgtaat atagatgata ttctcgatga tatagagggc
       670        680        690        700        710        720
gatttaacta taaaaccgac gataacgaaa ttcagcgatt tgccatcttc acccatcaag
       730        740        750        760        770        780
gcacccaacg ttgaaaaaaa agcagaggtg aatgcagaag aagtagataa aatggattca
       790        800        810        820        830        840
acaggagata gcaacgatgg cgatgactct ttgatagata ttttaactca aaagtatgtt
       850        860        870        880        890        900
gagaaacgca agagtgagag tcagataaca attcaaggca acaccaatca aaaaagtgga
       910        920        930        940        950        960
gcccaggaaa gttgtgggaa gaatgataac acaaaatcga gaggagaaat tgaagatcat
       970        980        990       1000       1010       1020
gaaaatgtag acaatcaagc caaaacaggc aatgcatttt atgagaatga agaagacagt
      1030       1040       1050       1060       1070       1080
aattgccaaa gaattaaaaa aaatgaaaaa atagaataca attcttcaga cgaattttca
      1090       1100       1110       1120       1130       1140
gacgattcac taattgaact attgaacgaa actcaaacac aagtggaacc taacactatt
      1150       1160       1170       1180       1190       1200
gaacaagatt tagacaaagt ggagaaaatg gtctctgacg atttgagaat tgctactgat
      1210       1220       1230       1240       1250       1260
tccactttat ccgcatatgc tctcagagct aagtctggtg ctccaagaga cggcgtagta
      1270       1280       1290       1300       1310       1320
cgattagtaa tagtaagctt acgtagtgtt gaattgccaa aaattggaac gcaaaaaata
      1330       1340       1350       1360       1370       1380
ctagagtgta tagacggcaa aggcgaacaa agttctgttg tcgttcgaca tccttgggta
      1390       1400       1410       1420       1430       1440
tatttggaat ttgaggttgg ggatgtaata catattatag aagggaaaaa tattgaaaac
      1450       1460       1470       1480       1490       1500
aaacggcttc tttctgacga caaaaaccct aaaactcaac tggctaacga caacctgttg
      1510       1520       1530       1540       1550       1560
gtgctaaacc ctgatgtatt attttcggca acatcagtcg gaagttcagt aggttgttta
      1570       1580       1590       1600       1610       1620
agacgttcaa ttctgcaaat gcaatttcaa gatccccgcg gagaaccaag ccttgtcatg
      1630       1640       1650       1660       1670       1680
actttaggca atatcgtaca cgagttattg caagactcaa tcaaatacaa gctctcgcat
      1690       1700       1710       1720       1730       1740
aataaaattt ctatggaaat cataatacaa aagctggatt ctttgttaga aacttattct
      1750       1760       1770       1780       1790       1800
ttttcaatta tcatttgtaa tgaagaaatc cagtacgtta aagaattagt tatgaaagaa
      1810       1820       1830       1840       1850       1860
catgctgaaa acattttgta cttcgtcaat aaatttgttt cgaaaagtaa ctatggttgc
      1870       1880       1890       1900       1910       1920
tacacatcaa tttccggaac aagaagaaca cagccaattt ctatatccaa tgtgattgat
      1930       1940       1950       1960       1970       1980
attgaagaaa acatttggtc tccaatatat ggtcttaaag ggttcctaga tgcaactgtt
      1990       2000       2010       2020       2030       2040
gaagctaatg ttgaaaacaa taaaaaacac atcgttcctt tagaagtgaa aactggaaaa
      2050       2060       2070       2080       2090       2100
tccagaagcg tttcatacga ggttcaaggc cttatttata cacttctgtt aaatgatcgc
      2110       2120       2130       2140       2150       2160
tatgagatac cgatagagtt ttttcttctt tattttacga gggataaaaa tatgacaaag
      2170       2180       2190       2200       2210       2220
ttcccttctg ttctgcactc cattaaacat attctcatgt cccgaaatag aatgagtatg
      2230       2240       2250       2260       2270       2280
aattttaagc atcaactcca agaggttttc ggacaggctc aatcaaggtt tgaattacca
      2290       2300       2310       2320       2330       2340
cccttactgc gcgattcatc ttgtgattca tgtttcatca aagaatcatg catggtgttg
      2350       2360       2370       2380       2390       2400
aataagctac tagaggacgg gacaccagaa gaaagtggcc tggtagaagg tgagtttgaa
      2410       2420       2430       2440       2450       2460
attttgacaa accatttgtc gcaaaatctc gccaactaca aagagttttt tacaaaatat
      2470       2480       2490       2500       2510       2520
aatgatctaa taactaagga ggagtcaagt ataacatgtg taaataaaga acttttctta
      2530       2540       2550       2560       2570       2580
ttggatggtt ccacaagaga atccagaagt ggaaggtgcc tttctggctt ggttgtgtca
      2590       2600       2610       2620       2630       2640
gaggtggttg aacatgaaaa aacagaggga gcgtatatat attgcttctc aagacgtaga
      2650       2660       2670       2680       2690       2700
aatgataata actcgcagtc gatgttatca tctcaaattg ctgctaatga ctttgttatt
      2710       2720       2730       2740       2750       2760
attagtgatg aggagggtca tttttgcttg tgccaaggtc gtgtacaatt tataaatccc
      2770       2780       2790       2800       2810       2820
gctaaaattg gtatctccgt aaaacgaaag ttattaaaca ataggcttct agataaggaa
      2830       2840       2850       2860       2870       2880
aaaggagtca ctaccatcca aagtgtggtc gaatcagagc tagaacaatc cagtctcata
      2890       2900       2910       2920       2930       2940
gctacccaaa atttggtcac atatagaatc gacaaaaatg atatccaaca gagtttgtct
      2950       2960       2970       2980       2990       3000
ttagcgcgat ttaatctttt aagcttgttt ttaccagctg tttcacctgg cgtggatatt
      3010       3020       3030       3040       3050       3060
gttgacgaaa ggagtaaatt atgtcggaag acaaagagat ctgatggagg taatgaaata
      3070       3080       3090       3100       3110       3120
ctgcgatcac ttttagttga taatagagca cctaagttta gagatgcaaa tgatgatccc
      3130       3140       3150       3160       3170       3180
gtcattccgt ataagctttc aaaggataca acattgaact tgaatcaaaa agaagcaata
      3190       3200       3210       3220       3230       3240
gacaaagtaa tgagggccga agattatgca ttgatattgg gaatgccagg gactggtaag
      3250       3260       3270       3280       3290       3300
actactgtta tcgcagaaat tattaaaatt ctcgtttccg aggggaaacg cgtgcttttg
      3310       3320       3330       3340       3350       3360
acatcataca cacattcagc agtggataat attttaataa aattgaggaa caccaacatt
      3370       3380       3390       3400       3410       3420
agcataatga gattgggaat gaaacataag gtccatcctg acacgcaaaa atatgtcccg
      3430       3440       3450       3460       3470       3480
aattacgcgt cagtgaaaag ttataacgat tatttgtcca aaattaacag cacctctgtt
      3490       3500       3510       3520       3530       3540
gttgctacca cctgcttagg aattaacgat atactattta cactaaatga aaaggatttt
      3550       3560       3570       3580       3590       3600
gattatgtga ttttggacga ggcaagtcaa atttcaatgc ctgtcgcttt gggacctctg
      3610       3620       3630       3640       3650       3660
cggtatggaa ataggtttat tatggtagga gatcattacc agctaccgcc attagttaaa
      3670       3680       3690       3700       3710       3720
aatgacgcag ctcgattagg tgggttagaa gagtcactgt tcaagacttt ctgtgaaaag
      3730       3740       3750       3760       3770       3780
catccggaaa gcgttgcaga actgacttta cagtaccgta tgtgcggcga tattgtaact
      3790       3800       3810       3820       3830       3840
ttgtctaatt tcctaattta tgataataaa ttaaaatgcg ggaataacga agtttttgct
      3850       3860       3870       3880       3890       3900
caatctttag agttaccaat gcctgaggcc ttgtcgcgct ataggaatga atcggctaac
      3910       3920       3930       3940       3950       3960
tctaagcagt ggcttgagga tatactagag cctacaagaa aagtggtatt tttaaattac
      3970       3980       3990       4000       4010       4020
gataactgcc cggatattat cgaacaaagc gaaaaggata acattacgaa tcacggggag
      4030       4040       4050       4060       4070       4080
gcagaattga ctctacaatg tgtggaagga atgttattga gcggcgtacc atgcgaagat
      4090       4100       4110       4120       4130       4140
attggtgtaa tgacgttata cagagcacag ttaagattac tgaagaagat attcaacaaa
      4150       4160       4170       4180       4190       4200
aatgtgtatg acgggctaga gatcttgact gctgatcagt ttcaaggtcg tgacaaaaag
      4210       4220       4230       4240       4250       4260
tgcattatta tttccatggt tagaagaaat tctcaattaa atggaggagc gctgctgaaa
      4270       4280       4290       4300       4310       4320
gagctaagaa gagtcaatgt tgccatgaca agggccaaat ccaagctgat cattataggt
      4330       4340       4350       4360       4370       4380
tcaaaaagta caatcggctc tgttcctgaa ataaaatcgt tcgtgaacct gttagaagag
      4390       4400       4410       4420       4430       4440
cgtaattggg tctatacaat gtgcaaggat gcactctaca aatacaaatt tcccgacaga
      4450       4460       4470       4480       4490       4500
tcaaacgcta ttgatgaggc acgcaaaggt tgtggaaaaa gaacaggtgc caaacccatc
      4510       4520       4530       4540       4550       4560
acatcaaagt ctaaattcgt aagcgataaa cctatcataa aggaaattct acaagagtat

gaaagttga     

Last modification date: Oct. 2, 2011