Homo sapiens L. (human) [HSA]

FULL NAME: DNA polymerase delta catalytic subunit


DESCRIPTION:
Possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3'- to 5'-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex.

MISCELLANEOUS:
In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-B family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


PROTEIN TYPE(S):
B-family DNA polymerase


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MDGKRRPGPG PGVPPKRARG GLWDDDDAPR PSQFEEDLAL MEEMEAEHRL QEQEEEELQS
        70         80         90        100        110        120
VLEGVADGQV PPSAIDPRWL RPTPPALDPQ TEPLIFQQLE IDHYVGPAQP VPGGPPPSRG
       130        140        150        160        170        180
SVPVLRAFGV TDEGFSVCCH IHGFAPYFYT PAPPGFGPEH MGDLQRELNL AISRDSRGGR
       190        200        210        220        230        240
ELTGPAVLAV ELCSRESMFG YHGHGPSPFL RITVALPRLV APARRLLEQG IRVAGLGTPS
       250        260        270        280        290        300
FAPYEANVDF EIRFMVDTDI VGCNWLELPA GKYALRLKEK ATQCQLEADV LWSDVVSHPP
       310        320        330        340        350        360
EGPWQRIAPL RVLSFDIECA GRKGIFPEPE RDPVIQICSL GLRWGEPEPF LRLALTLRPC
       370        380        390        400        410        420
APILGAKVQS YEKEEDLLQA WSTFIRIMDP DVITGYNIQN FDLPYLISRA QTLKVQTFPF
       430        440        450        460        470        480
LGRVAGLCSN IRDSSFQSKQ TGRRDTKVVS MVGRVQMDML QVLLREYKLR SYTLNAVSFH
       490        500        510        520        530        540
FLGEQKEDVQ HSIITDLQNG NDQTRRRLAV YCLKDAYLPL RLLERLMVLV NAVEMARVTG
       550        560        570        580        590        600
VPLSYLLSRG QQVKVVSQLL RQAMHEGLLM PVVKSEGGED YTGATVIEPL KGYYDVPIAT
       610        620        630        640        650        660
LDFSSLYPSI MMAHNLCYTT LLRPGTAQKL GLTEDQFIRT PTGDEFVKTS VRKGLLPQIL
       670        680        690        700        710        720
ENLLSARKRA KAELAKETDP LRRQVLDGRQ LALKVSANSV YGFTGAQVGK LPCLEISQSV
       730        740        750        760        770        780
TGFGRQMIEK TKQLVESKYT VENGYSTSAK VVYGDTDSVM CRFGVSSVAE AMALGREAAD
       790        800        810        820        830        840
WVSGHFPSPI RLEFEKVYFP YLLISKKRYA GLLFSSRPDA HDRMDCKGLE AVRRDNCPLV
       850        860        870        880        890        900
ANLVTASLRR LLIDRDPEGA VAHAQDVISD LLCNRIDISQ LVITKELTRA ASDYAGKQAH
       910        920        930        940        950        960
VELAERMRKR DPGSAPSLGD RVPYVIISAA KGVAAYMKSE DPLFVLEHSL PIDTQYYLEQ
       970        980        990       1000       1010       1020
QLAKPLLRIF EPILGEGRAE AVLLRGDHTR CKTVLTGKVG GLLAFAKRRN CCIGCRTVLS
      1030       1040       1050       1060       1070       1080
HQGAVCEFCQ PRESELYQKE VSHLNALEER FSRLWTQCQR CQGSLHEDVI CTSRDCPIFY
      1090       1100
MRKKVRKDLE DQEQLLRRFG PPGPEAW   

Encoded by POLD1 gene

FULL NAME: polymerase (DNA directed), delta 1, catalytic subunit 125kDa


OTHER NAME(S):
CDC2
POLD


DESCRIPTION:
The DNA polymerase delta complex is involved in DNA replication and repair, and it consists of the proliferating cell nuclear antigen (PCNA; MIM 176740), the multisubunit replication factor C (see MIM 102579), and the 4 subunit polymerase complex: POLD1, POLD2 (MIM 600815), POLD3 (MIM 611415), and POLD4 (MIM 611525) (Liu and Warbrick, 2006 [PubMed 16934752]).[supplied by OMIM, Mar 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggatggca agcggcggcc aggcccaggg cccggggtgc ccccaaagcg ggcccgtggg
        70         80         90        100        110        120
ggcctctggg atgatgatga tgcacctcgg ccatcccaat tcgaggagga cctggcactg
       130        140        150        160        170        180
atggaggaga tggaggcaga acacaggctg caggagcagg aggaggagga gctgcagtca
       190        200        210        220        230        240
gtcctggagg gggttgcaga cgggcaggtc ccaccatcag ccatagatcc tcgctggctt
       250        260        270        280        290        300
cggcccacac caccagcgct ggacccccag acagagcccc tcatcttcca acagttggag
       310        320        330        340        350        360
attgaccatt atgtgggccc agcgcagcct gtgcctgggg ggcccccacc atcccgcggc
       370        380        390        400        410        420
tccgtgcctg tgctccgcgc cttcggggtc accgatgagg ggttctctgt ctgctgccac
       430        440        450        460        470        480
atccacggct tcgctcccta cttctacacc ccagcgcccc ctggtttcgg gcccgagcac
       490        500        510        520        530        540
atgggtgacc tgcaacggga gctgaacttg gccatcagcc gggacagtcg cggggggagg
       550        560        570        580        590        600
gagctgactg ggccggccgt gctggctgtg gaactgtgct cccgagagag catgtttggg
       610        620        630        640        650        660
taccacgggc acggcccctc cccgttcctg cgcatcaccg tggcgctgcc gcgcctcgtg
       670        680        690        700        710        720
gccccggccc gccgtctcct ggaacagggc atccgtgtgg caggcctggg cacgcccagc
       730        740        750        760        770        780
ttcgcgccct acgaggccaa cgtcgacttt gagatccggt tcatggtgga cacggacatc
       790        800        810        820        830        840
gtcggctgca actggctgga gctcccagct gggaaatacg ccctgaggct gaaggagaag
       850        860        870        880        890        900
gctacgcagt gccagctgga ggcggacgtg ctgtggtctg acgtggtcag tcacccaccg
       910        920        930        940        950        960
gaagggccat ggcagcgcat tgcgcccttg cgcgtgctca gcttcgatat cgagtgcgcc
       970        980        990       1000       1010       1020
ggccgcaaag gcatcttccc tgagcctgag cgggaccctg tcatccagat ctgctcgctg
      1030       1040       1050       1060       1070       1080
ggcctgcgct ggggggagcc ggagcccttc ctacgcctgg cgctcaccct gcggccctgt
      1090       1100       1110       1120       1130       1140
gcccccatcc tgggtgccaa ggtgcagagc tacgagaagg aggaggacct gctgcaggcc
      1150       1160       1170       1180       1190       1200
tggtccacct tcatccgtat catggacccc gacgtgatca ccggttacaa catccagaac
      1210       1220       1230       1240       1250       1260
ttcgaccttc cgtacctcat ctctcgggcc cagaccctca aggtacaaac attccctttc
      1270       1280       1290       1300       1310       1320
ctgggccgtg tggccggcct ttgctccaac atccgggact cttcattcca gtccaagcag
      1330       1340       1350       1360       1370       1380
acgggccggc gggacaccaa ggttgtcagc atggtgggcc gcgtgcagat ggacatgctg
      1390       1400       1410       1420       1430       1440
caggtgctgc tgcgggagta caagctccgc tcctacacgc tcaatgccgt gagcttccac
      1450       1460       1470       1480       1490       1500
ttcctgggcg agcagaagga ggacgtgcag cacagcatca tcaccgacct gcagaatggg
      1510       1520       1530       1540       1550       1560
aacgaccaga cccgccgccg cctggctgtg tactgcctga aggatgccta cctgccactg
      1570       1580       1590       1600       1610       1620
cggctgctgg agcggctcat ggtgctggtg aacgccgtgg agatggcgag ggtcactggc
      1630       1640       1650       1660       1670       1680
gtgcccctca gctacctgct cagtcgtggc cagcaggtca aggtcgtatc ccagctgttg
      1690       1700       1710       1720       1730       1740
cggcaggcca tgcacgaggg gctgctgatg cccgtggtga agtcagaggg cggcgaggac
      1750       1760       1770       1780       1790       1800
tacacgggag ccactgtcat cgagcccctc aaagggtact acgacgtccc catcgccacc
      1810       1820       1830       1840       1850       1860
ctggacttct cctcgctgta cccgtccatc atgatggccc acaacctgtg ttacaccacg
      1870       1880       1890       1900       1910       1920
ctccttcggc ccgggactgc acagaaactg ggcctgactg aggatcagtt catcaggacc
      1930       1940       1950       1960       1970       1980
cccaccgggg acgagtttgt gaagacctca gtgcggaagg ggctgctgcc ccagatcctg
      1990       2000       2010       2020       2030       2040
gagaacctgc tcagtgcccg gaagagggcc aaggccgagc tggccaagga gacagacccc
      2050       2060       2070       2080       2090       2100
ctccggcgcc aggtcctgga tggacggcag ctggcgctga aggtgagcgc caactccgta
      2110       2120       2130       2140       2150       2160
tacggcttca ctggcgccca ggtgggcaag ttgccgtgcc tggagatctc acagagcgtc
      2170       2180       2190       2200       2210       2220
acggggttcg gacgtcagat gatcgagaaa accaagcagc tggtggagtc taagtacaca
      2230       2240       2250       2260       2270       2280
gtggagaatg gctacagcac cagtgccaag gtggtgtatg gtgacactga ctccgtcatg
      2290       2300       2310       2320       2330       2340
tgccgattcg gcgtgtcctc ggtggctgag gcgatggccc tggggcggga ggccgcggac
      2350       2360       2370       2380       2390       2400
tgggtgtcag gtcacttccc gtcgcccatc cggctggagt ttgagaaggt ctacttccca
      2410       2420       2430       2440       2450       2460
tacctgctta tcagcaagaa gcgctacgcg ggcctgctct tctcctcccg gcccgacgcc
      2470       2480       2490       2500       2510       2520
cacgaccgca tggactgcaa gggcctggag gccgtgcgca gggacaactg ccccctcgtg
      2530       2540       2550       2560       2570       2580
gccaacctgg tcactgcctc actgcgccgc ctgctcatcg accgagaccc tgagggcgcg
      2590       2600       2610       2620       2630       2640
gtggctcacg cacaggacgt catctcggac ctgctgtgca accgcatcga tatctcccag
      2650       2660       2670       2680       2690       2700
ctggtcatca ccaaggagct gacccgcgcg gcctccgact atgccggcaa gcaggcccac
      2710       2720       2730       2740       2750       2760
gtggagctgg ccgagaggat gaggaagcgg gaccccggga gtgcgcccag cctgggcgac
      2770       2780       2790       2800       2810       2820
cgcgtcccct acgtgatcat cagtgccgcc aagggtgtgg ccgcctacat gaagtcggag
      2830       2840       2850       2860       2870       2880
gacccgctgt tcgtgctgga gcacagcctg cccattgaca cgcagtacta cctggagcag
      2890       2900       2910       2920       2930       2940
cagctggcca agcccctcct gcgcatcttc gagcccatcc tgggcgaggg ccgtgccgag
      2950       2960       2970       2980       2990       3000
gctgtgctac tgcgggggga ccacacgcgc tgcaagacgg tgctcacggg caaggtgggc
      3010       3020       3030       3040       3050       3060
ggcctcctgg ccttcgccaa acgccgcaac tgctgcattg gctgccgcac agtgctcagc
      3070       3080       3090       3100       3110       3120
caccagggag ccgtgtgtga gttctgccag ccccgggagt ctgagctgta tcagaaggag
      3130       3140       3150       3160       3170       3180
gtatcccatc tgaatgccct ggaggagcgc ttctcgcgcc tctggacgca gtgccagcgc
      3190       3200       3210       3220       3230       3240
tgccagggca gcctgcacga ggacgtcatc tgcaccagcc gggactgccc catcttctac
      3250       3260       3270       3280       3290       3300
atgcgcaaga aggtgcggaa ggacctggaa gaccaggagc agctcctgcg gcgcttcgga
      3310       3320
ccccctggac ctgaggcctg gtga   

Last modification date: Oct. 2, 2011