Mus musculus L. (mouse) [MMU]

FULL NAME: DNA (cytosine-5)-methyltransferase 3-like


DESCRIPTION:
Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases.

STRUCTURE SIMILARITY:
Contains 1 GATA-type zinc finger.
Belongs to the C5-methyltransferase family.
Contains 1 PHD-type zinc finger.
Contains 1 ADD domain.


PROTEIN TYPE(S):
accessory protein


RELATED PATHWAY(S):
DNA replication
heterochromatin formation


Amino acids sequence

        10         20         30         40         50         60
MGSRETPSSC SKTLETLDLE TSDSSSPDAD SPLEEQWLKS SPALKEDSVD VVLEDCKEPL
        70         80         90        100        110        120
SPSSPPTGRE MIRYEVKVNR RSIEDICLCC GTLQVYTRHP LFEGGLCAPC KDKFLESLFL
       130        140        150        160        170        180
YDDDGHQSYC TICCSGGTLF ICESPDCTRC YCFECVDILV GPGTSERINA MACWVCFLCL
       190        200        210        220        230        240
PFSRSGLLQR RKRWRHQLKA FHDQEGAGPM EIYKTVSAWK RQPVRVLSLF RNIDKVLKSL
       250        260        270        280        290        300
GFLESGSGSG GGTLKYVEDV TNVVRRDVEK WGPFDLVYGS TQPLGSSCDR CPGWYMFQFH
       310        320        330        340        350        360
RILQYALPRQ ESQRPFFWIF MDNLLLTEDD QETTTRFLQT EAVTLQDVRG RDYQNAMRVW
       370        380        390        400        410        420
SNIPGLKSKH APLTPKEEEY LQAQVRSRSK LDAPKVDLLV KNCLLPLREY FKYFSQNSLP

L     

Encoded by Dnmt3l gene

FULL NAME: DNA (cytosine-5-)-methyltransferase 3-like


OTHER NAME(S):
D6Ertd14e
MGC102308
ecat7


Nucleic acid sequence

        10         20         30         40         50         60
atgggttccc gggagacacc ttcttcttgc tctaagaccc ttgaaacctt ggacctggag
        70         80         90        100        110        120
acttccgaca gctctagccc tgatgctgac agtcctctgg aagagcaatg gctgaaatcc
       130        140        150        160        170        180
tccccagccc tgaaggagga cagtgtggat gtggtactgg aagactgcaa agagcctctg
       190        200        210        220        230        240
tccccctcct cgcctccgac aggcagagag atgatcaggt acgaagtcaa agtgaaccga
       250        260        270        280        290        300
cggagcattg aagacatctg cctctgctgt ggaactctcc aggtgtacac tcggcacccc
       310        320        330        340        350        360
ttgtttgagg gagggttatg tgccccatgt aaggataagt tcctggagtc cctcttcctg
       370        380        390        400        410        420
tatgatgatg atggacacca gagttactgc accatctgct gttccggggg taccctgttc
       430        440        450        460        470        480
atctgtgaga gccccgactg taccagatgc tactgtttcg agtgtgtgga catcctggtg
       490        500        510        520        530        540
ggccccggga cctcagagag gatcaatgcc atggcctgct gggtttgctt cctgtgcctg
       550        560        570        580        590        600
cccttctcac ggagtggact gctgcagagg cgcaagaggt ggcggcacca gctgaaggcc
       610        620        630        640        650        660
ttccatgatc aagagggagc gggccctatg gagatataca agacagtgtc tgcatggaag
       670        680        690        700        710        720
agacagccag tgcgggtact gagccttttt agaaatattg ataaagtact aaagagtttg
       730        740        750        760        770        780
ggctttttgg aaagcggttc tggttctggg ggaggaacgc tgaagtacgt ggaagatgtc
       790        800        810        820        830        840
acaaatgtcg tgaggagaga cgtggagaaa tggggcccct ttgacctggt gtacggctcg
       850        860        870        880        890        900
acgcagcccc taggcagctc ttgtgatcgc tgtcccggct ggtacatgtt ccagttccac
       910        920        930        940        950        960
cggatcctgc agtatgcgct gcctcgccag gagagtcagc ggcccttctt ctggatattc
       970        980        990       1000       1010       1020
atggacaatc tgctgctgac tgaggatgac caagagacaa ctacccgctt ccttcagaca
      1030       1040       1050       1060       1070       1080
gaggctgtga ccctccagga tgtccgtggc agagactacc agaatgctat gcgggtgtgg
      1090       1100       1110       1120       1130       1140
agcaacattc cagggctgaa gagcaagcat gcgcccctga ccccaaagga agaagagtat
      1150       1160       1170       1180       1190       1200
ctgcaagccc aagtcagaag caggagcaag ctggacgccc cgaaagttga cctcctggtg
      1210       1220       1230       1240       1250       1260
aagaactgcc ttctcccgct gagagagtac ttcaagtatt tttctcaaaa ctcacttcct

ctttag     

Last modification date: Oct. 2, 2011