Mus musculus L. (mouse) [MMU]

FULL NAME: DNA (cytosine-5)-methyltransferase 3B


DESCRIPTION:
Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9 (By similarity).

STRUCTURE SIMILARITY:
Contains 1 GATA-type zinc finger.
Belongs to the C5-methyltransferase family.
Contains 1 PWWP domain.
Contains 1 PHD-type zinc finger.
Contains 1 ADD domain.


CATALYTIC ACTIVITY:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.


ENZYME REGULATION:
Activated by binding to the regulatory factor DNMT3L.


POST-TRANSLATIONAL MODIFICATION:
Sumoylated (By similarity).


PROTEIN TYPE(S):
DNA methyltransferase


RELATED PATHWAY(S):
DNA replication
heterochromatin formation


Amino acids sequence

        10         20         30         40         50         60
MKGDSRHLNE EEGASGYEEC IIVNGNFSDQ SSDTKDAPSP PVLEAICTEP VCTPETRGRR
        70         80         90        100        110        120
SSSRLSKREV SSLLNYTQDM TGDGDRDDEV DDGNGSDILM PKLTRETKDT RTRSESPAVR
       130        140        150        160        170        180
TRHSNGTSSL ERQRASPRIT RGRQGRHHVQ EYPVEFPATR SRRRRASSSA STPWSSPASV
       190        200        210        220        230        240
DFMEEVTPKS VSTPSVDLSQ DGDQEGMDTT QVDAESRDGD STEYQDDKEF GIGDLVWGKI
       250        260        270        280        290        300
KGFSWWPAMV VSWKATSKRQ AMPGMRWVQW FGDGKFSEIS ADKLVALGLF SQHFNLATFN
       310        320        330        340        350        360
KLVSYRKAMY HTLEKARVRA GKTFSSSPGE SLEDQLKPML EWAHGGFKPT GIEGLKPNKK
       370        380        390        400        410        420
QPVVNKSKVR RSDSRNLEPR RRENKSRRRT TNDSAASESP PPKRLKTNSY GGKDRGEDEE
       430        440        450        460        470        480
SRERMASEVT NNKGNLEDRC LSCGKKNPVS FHPLFEGGLC QSCRDRFLEL FYMYDEDGYQ
       490        500        510        520        530        540
SYCTVCCEGR ELLLCSNTSC CRCFCVECLE VLVGAGTAED AKLQEPWSCY MCLPQRCHGV
       550        560        570        580        590        600
LRRRKDWNMR LQDFFTTDPD LEEFEPPKLY PAIPAAKRRP IRVLSLFDGI ATGYLVLKEL
       610        620        630        640        650        660
GIKVEKYIAS EVCAESIAVG TVKHEGQIKY VNDVRKITKK NIEEWGPFDL VIGGSPCNDL
       670        680        690        700        710        720
SNVNPARKGL YEGTGRLFFE FYHLLNYTRP KEGDNRPFFW MFENVVAMKV NDKKDISRFL
       730        740        750        760        770        780
ACNPVMIDAI KVSAAHRARY FWGNLPGMNR PVMASKNDKL ELQDCLEFSR TAKLKKVQTI
       790        800        810        820        830        840
TTKSNSIRQG KNQLFPVVMN GKDDVLWCTE LERIFGFPAH YTDVSNMGRG ARQKLLGRSW
       850
SVPVIRHLFA PLKDYFACE    

Encoded by Dnmt3b gene

FULL NAME: DNA methyltransferase 3B


OTHER NAME(S):
MGC124407


Nucleic acid sequence

        10         20         30         40         50         60
atgaagggag acagcagaca tctgaatgaa gaagagggtg ccagcgggta tgaggagtgc
        70         80         90        100        110        120
attatcgtta atgggaactt cagtgaccag tcctcagaca cgaaggatgc tccctcaccc
       130        140        150        160        170        180
ccagtcttgg aggcaatctg cacagagcca gtctgcacac cagagaccag aggccgcagg
       190        200        210        220        230        240
tcaagctccc ggctgtctaa gagggaggtc tccagccttc tgaattacac gcaggacatg
       250        260        270        280        290        300
acaggagatg gagacagaga tgatgaagta gatgatggga atggctctga tattctaatg
       310        320        330        340        350        360
ccaaagctca cccgtgagac caaggacacc aggacgcgct ctgaaagccc ggctgtccga
       370        380        390        400        410        420
acccgacata gcaatgggac ctccagcttg gagaggcaaa gagcctcccc cagaatcacc
       430        440        450        460        470        480
cgaggtcggc agggccgcca ccatgtgcag gagtaccctg tggagtttcc ggctaccagg
       490        500        510        520        530        540
tctcggagac gtcgagcatc atcttcagca agcacgccat ggtcatcccc tgccagcgtc
       550        560        570        580        590        600
gacttcatgg aagaagtgac acctaagagc gtcagtaccc catcagttga cttgagccag
       610        620        630        640        650        660
gatggagatc aggagggtat ggataccaca caggtggatg cagagagcag agatggagac
       670        680        690        700        710        720
agcacagagt atcaggatga taaagagttt ggaataggtg acctcgtgtg gggaaagatc
       730        740        750        760        770        780
aagggcttct cctggtggcc tgccatggtg gtgtcctgga aagccacctc caagcgacag
       790        800        810        820        830        840
gccatgcccg gaatgcgctg ggtacagtgg tttggtgatg gcaagttttc tgagatctct
       850        860        870        880        890        900
gctgacaaac tggtggctct ggggctgttc agccagcact ttaatctggc taccttcaat
       910        920        930        940        950        960
aagctggttt cttataggaa ggccatgtac cacactctgg agaaagccag ggttcgagct
       970        980        990       1000       1010       1020
ggcaagacct tctccagcag tcctggagag tcactggagg accagctgaa gcccatgctg
      1030       1040       1050       1060       1070       1080
gagtgggccc acggtggctt caagcctact gggatcgagg gcctcaaacc caacaagaag
      1090       1100       1110       1120       1130       1140
caaccagaga acaaaagtcg aagacgcaca accaatgact ctgctgcttc tgagtccccc
      1150       1160       1170       1180       1190       1200
ccacccaagc gcctcaagac aaatagctat ggcgggaagg accgagggga ggatgaggag
      1210       1220       1230       1240       1250       1260
agccgagaac ggatggcttc tgaagtcacc aacaacaagg gcaatctgga agaccgctgt
      1270       1280       1290       1300       1310       1320
ttgtcctgtg gaaagaagaa ccctgtgtcc ttccaccccc tctttgaggg tgggctctgt
      1330       1340       1350       1360       1370       1380
cagagttgcc gggatcgctt cctagagctc ttctacatgt atgatgagga cggctatcag
      1390       1400       1410       1420       1430       1440
tcctactgca ccgtgtgctg tgagggccgt gaactgctgc tgtgcagtaa cacaagctgc
      1450       1460       1470       1480       1490       1500
tgcagatgct tctgtgtgga gtgtctggag gtgctggtgg gcgcaggcac agctgaggat
      1510       1520       1530       1540       1550       1560
gccaagctgc aggaaccctg gagctgctat atgtgcctcc ctcagcgctg ccatggggtc
      1570       1580       1590       1600       1610       1620
ctccgacgca ggaaagattg gaacatgcgc ctgcaagact tcttcactac tgatcctgac
      1630       1640       1650       1660       1670       1680
ctggaagaat ttgagccacc caagttgtac ccagcaattc ctgcagccaa aaggaggccc
      1690       1700       1710       1720       1730       1740
attagagtcc tgtctctgtt tgatggaatt gcaacggggt acttggtgct caaggagttg
      1750       1760       1770       1780       1790       1800
ggtattaaag tggaaaagta cattgcctcc gaagtctgtg cagagtccat cgctgtggga
      1810       1820       1830       1840       1850       1860
actgttaagc atgaaggcca gatcaaatat gtcaatgacg tccggaaaat caccaagaaa
      1870       1880       1890       1900       1910       1920
aatattgaag agtggggccc gttcgacttg gtgattggtg gaagcccatg caatgatctc
      1930       1940       1950       1960       1970       1980
tctaacgtca atcctgcccg caaaggttta tatgagggca caggaaggct cttcttcgag
      1990       2000       2010       2020       2030       2040
ttttaccact tgctgaatta tacccgcccc aaggagggcg acaaccgtcc attcttctgg
      2050       2060       2070       2080       2090       2100
atgttcgaga atgttgtggc catgaaagtg aatgacaaga aagacatctc aagattcctg
      2110       2120       2130       2140       2150       2160
gcatgtaacc cagtgatgat cgatgccatc aaggtgtctg ctgctcacag ggcccggtac
      2170       2180       2190       2200       2210       2220
ttctggggta acctacccgg aatgaacagg cccgtgatgg cttcaaagaa tgataagctc
      2230       2240       2250       2260       2270       2280
gagctgcagg actgcctgga gttcagtagg acagcaaagt taaagaaagt gcagacaata
      2290       2300       2310       2320       2330       2340
accaccaagt cgaactccat cagacagggc aaaaaccagc ttttccctgt agtcatgaat
      2350       2360       2370       2380       2390       2400
ggcaaggacg acgttttgtg gtgcactgag ctcgaaagga tcttcggctt ccctgctcac
      2410       2420       2430       2440       2450       2460
tacacggacg tgtccaacat gggccgcggc gcccgtcaga agctgctggg caggtcctgg
      2470       2480       2490       2500       2510       2520
agtgtaccgg tcatcagaca cctgtttgcc cccttgaagg actactttgc ctgtgaatag

Last modification date: Oct. 2, 2011