Homo sapiens L. (human) [HSA]

FULL NAME: DNA (cytosine-5)-methyltransferase 3-like


DESCRIPTION:
Catalytically inactive regulatory factor of DNA methyltransferases. It is essential for the function of DNMT3A and DNMT3B. Activates DNMT3A and DNMT3B by binding to their catalytic domain. Accelerates the binding of DNA and AdoMet to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases. Recognizes unmethylated histone H3 lysine 4 (H3K4) and induces de novo DNA methylation by recruitment or activation of DNMT3.

MISCELLANEOUS:
Interaction with histone H3 is strongly inhibited by methylation at lysine 4 (H3K4me).


STRUCTURE SIMILARITY:
Contains 1 GATA-type zinc finger.
Belongs to the C5-methyltransferase family.
Contains 1 PHD-type zinc finger.
Contains 1 ADD domain.


PROTEIN TYPE(S):
accessory protein


RELATED PATHWAY(S):
DNA replication
heterochromatin formation


Amino acids sequence

        10         20         30         40         50         60
MAAIPALDPE AEPSMDVILV GSSELSSSVS PGTGRDLIAY EVKANQRNIE DICICCGSLQ
        70         80         90        100        110        120
VHTQHPLFEG GICAPCKDKF LDALFLYDDD GYQSYCSICC SGETLLICGN PDCTRCYCFE
       130        140        150        160        170        180
CVDSLVGPGT SGKVHAMSNW VCYLCLPSSR SGLLQRRRKW RSQLKAFYDR ESENPLEMFE
       190        200        210        220        230        240
TVPVWRRQPV RVLSLFEDIK KELTSLGFLE SGSDPGQLKH VVDVTDTVRK DVEEWGPFDL
       250        260        270        280        290        300
VYGATPPLGH TCDRPPSWYL FQFHRLLQYA RPKPGSPRPF FWMFVDNLVL NKEDLDVASR
       310        320        330        340        350        360
FLEMEPVTIP DVHGGSLQNA VRVWSNIPAI RSRHWALVSE EELSLLAQNK QSSKLAAKWP
       370        380
TKLVKNCFLP LREYFKYFST ELTSSL   

Encoded by DNMT3L gene

FULL NAME: DNA (cytosine-5-)-methyltransferase 3-like


OTHER NAME(S):
MGC1090


DESCRIPTION:
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases. This protein is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, this protein does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and it is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternative splicing results in two transcript variants. An additional splice variant has been described but its biological validity has not been determined. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggcggcca tcccagccct ggacccagag gccgagccca gcatggacgt gattttggtg
        70         80         90        100        110        120
ggatccagtg agctctcaag ctccgtttca cccgggacag gcagagatct tattgcatat
       130        140        150        160        170        180
gaagtcaagg ctaaccagcg aaatatagaa gacatctgca tctgctgcgg aagtctccag
       190        200        210        220        230        240
gttcacacac agcaccctct gtttgaggga gggatctgcg ccccatgtaa ggacaagttc
       250        260        270        280        290        300
ctggatgccc tcttcctgta cgacgatgac gggtaccaat cctactgctc catctgctgc
       310        320        330        340        350        360
tccggagaga cgctgctcat ctgcggaaac cctgattgca cccgatgcta ctgcttcgag
       370        380        390        400        410        420
tgtgtggata gcctggtcgg ccccgggacc tcggggaagg tgcacgccat gagcaactgg
       430        440        450        460        470        480
gtgtgctacc tgtgcctgcc gtcctcccga agcgggctgc tgcagcgtcg gaggaagtgg
       490        500        510        520        530        540
cgcagccagc tcaaggcctt ctacgaccga gagtcggaga atccccttga gatgttcgaa
       550        560        570        580        590        600
accgtgcctg tgtggaggag acagccagtc cgggtgctgt ccctttttga agacatcaag
       610        620        630        640        650        660
aaagagctga cgagtttggg ctttttggaa agtggttctg acccgggaca actgaagcat
       670        680        690        700        710        720
gtggttgatg tcacagacac agtgaggaag gatgtggagg agtggggacc cttcgatctt
       730        740        750        760        770        780
gtgtacggcg ccacacctcc cctgggccac acctgtgacc gtcctcccag ctggtacctg
       790        800        810        820        830        840
ttccagttcc accggctcct gcagtacgca cggcccaagc caggcagccc caggcccttc
       850        860        870        880        890        900
ttctggatgt tcgtggacaa tctggtgctg aacaaggaag acctggacgt cgcatctcgc
       910        920        930        940        950        960
ttcctggaga tggagccagt caccatccca gatgtccacg gcggatcctt gcagaatgct
       970        980        990       1000       1010       1020
gtccgcgtgt ggagcaacat cccagccata aggagcagca ggcactgggc tctggtttcg
      1030       1040       1050       1060       1070       1080
gaagaagaat tgtccctgct ggcccagaac aagcagagct cgaagctcgc ggccaagtgg
      1090       1100       1110       1120       1130       1140
cccaccaagc tggtgaagaa ctgctttctc cccctaagag aatatttcaa gtatttttca
      1150       1160
acagaactca cttcctcttt ataa   

Last modification date: Oct. 2, 2011