Homo sapiens L. (human) [HSA]

FULL NAME: DNA (cytosine-5)-methyltransferase 3A


DESCRIPTION:
Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity (By similarity).

STRUCTURE SIMILARITY:
Contains 1 GATA-type zinc finger.
Belongs to the C5-methyltransferase family.
Contains 1 PWWP domain.
Contains 1 PHD-type zinc finger.
Contains 1 ADD domain.


CATALYTIC ACTIVITY:
S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.


ENZYME REGULATION:
Activated by binding to the regulatory factor DNMT3L (By similarity).


POST-TRANSLATIONAL MODIFICATION:
Sumoylated; sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription (By similarity).


PROTEIN TYPE(S):
DNA methyltransferase


RELATED PATHWAY(S):
DNA replication
heterochromatin formation


Amino acids sequence

        10         20         30         40         50         60
MPAMPSSGPG DTSSSAAERE EDRKDGEEQE EPRGKEERQE PSTTARKVGR PGRKRKHPPV
        70         80         90        100        110        120
ESGDTPKDPA VISKSPSMAQ DSGASELLPN GDLEKRSEPQ PEEGSPAGGQ KGGAPAEGEG
       130        140        150        160        170        180
AAETLPEASR AVENGCCTPK EGRGAPAEAG KEQKETNIES MKMEGSRGRL RGGLGWESSL
       190        200        210        220        230        240
RQRPMPRLTF QAGDPYYISK RKRDEWLARW KREAEKKAKV IAGMNAVEEN QGPGESQKVE
       250        260        270        280        290        300
EASPPAVQQP TDPASPTVAT TPEPVGSDAG DKNATKAGDD EPEYEDGRGF GIGELVWGKL
       310        320        330        340        350        360
RGFSWWPGRI VSWWMTGRSR AAEGTRWVMW FGDGKFSVVC VEKLMPLSSF CSAFHQATYN
       370        380        390        400        410        420
KQPMYRKAIY EVLQVASSRA GKLFPVCHDS DESDTAKAVE VQNKPMIEWA LGGFQPSGPK
       430        440        450        460        470        480
GLEPPEEEKN PYKEVYTDMW VEPEAAAYAP PPPAKKPRKS TAEKPKVKEI IDERTRERLV
       490        500        510        520        530        540
YEVRQKCRNI EDICISCGSL NVTLEHPLFV GGMCQNCKNC FLECAYQYDD DGYQSYCTIC
       550        560        570        580        590        600
CGGREVLMCG NNNCCRCFCV ECVDLLVGPG AAQAAIKEDP WNCYMCGHKG TYGLLRRRED
       610        620        630        640        650        660
WPSRLQMFFA NNHDQEFDPP KVYPPVPAEK RKPIRVLSLF DGIATGLLVL KDLGIQVDRY
       670        680        690        700        710        720
IASEVCEDSI TVGMVRHQGK IMYVGDVRSV TQKHIQEWGP FDLVIGGSPC NDLSIVNPAR
       730        740        750        760        770        780
KGLYEGTGRL FFEFYRLLHD ARPKEGDDRP FFWLFENVVA MGVSDKRDIS RFLESNPVMI
       790        800        810        820        830        840
DAKEVSAAHR ARYFWGNLPG MNRPLASTVN DKLELQECLE HGRIAKFSKV RTITTRSNSI
       850        860        870        880        890        900
KQGKDQHFPV FMNEKEDILW CTEMERVFGF PVHYTDVSNM SRLARQRLLG RSWSVPVIRH
       910
LFAPLKEYFA CV    

Encoded by DNMT3A gene

FULL NAME: DNA (cytosine-5-)-methyltransferase 3 alpha


OTHER NAME(S):
DNMT3A2
M.HsaIIIA


DESCRIPTION:
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgcccgcca tgccctccag cggccccggg gacaccagca gctctgctgc ggagcgggag
        70         80         90        100        110        120
gaggaccgaa aggacggaga ggagcaggag gagccgcgtg gcaaggagga gcgccaagag
       130        140        150        160        170        180
cccagcacca cggcacggaa ggtggggcgg cctgggagga agcgcaagca ccccccggtg
       190        200        210        220        230        240
gaaagcggtg acacgccaaa ggaccctgcg gtgatctcca agtccccatc catggcccag
       250        260        270        280        290        300
gactcaggcg cctcagagct attacccaat ggggacttgg agaagcggag tgagccccag
       310        320        330        340        350        360
ccagaggagg ggagccctgc tggggggcag aagggcgggg ccccagcaga gggagagggt
       370        380        390        400        410        420
gcagctgaga ccctgcctga agcctcaaga gcagtggaaa atggctgctg cacccccaag
       430        440        450        460        470        480
gagggccgag gagcccctgc agaagcgggc aaagaacaga aggagaccaa catcgaatcc
       490        500        510        520        530        540
atgaaaatgg agggctcccg gggccggctg cggggtggct tgggctggga gtccagcctc
       550        560        570        580        590        600
cgtcagcggc ccatgccgag gctcaccttc caggcggggg acccctacta catcagcaag
       610        620        630        640        650        660
cgcaagcggg acgagtggct ggcacgctgg aaaagggagg ctgagaagaa agccaaggtc
       670        680        690        700        710        720
attgcaggaa tgaatgctgt ggaagaaaac caggggcccg gggagtctca gaaggtggag
       730        740        750        760        770        780
gaggccagcc ctcctgctgt gcagcagccc actgaccccg catcccccac tgtggctacc
       790        800        810        820        830        840
acgcctgagc ccgtggggtc cgatgctggg gacaagaatg ccaccaaagc aggcgatgac
       850        860        870        880        890        900
gagccagagt acgaggacgg ccggggcttt ggcattgggg agctggtgtg ggggaaactg
       910        920        930        940        950        960
cggggcttct cctggtggcc aggccgcatt gtgtcttggt ggatgacggg ccggagccga
       970        980        990       1000       1010       1020
gcagctgaag gcacccgctg ggtcatgtgg ttcggagacg gcaaattctc agtggtgtgt
      1030       1040       1050       1060       1070       1080
gttgagaagc tgatgccgct gagctcgttt tgcagtgcgt tccaccaggc cacgtacaac
      1090       1100       1110       1120       1130       1140
aagcagccca tgtaccgcaa agccatctac gaggtcctgc aggtggccag cagccgcgcg
      1150       1160       1170       1180       1190       1200
gggaagctgt tcccggtgtg ccacgacagc gatgagagtg acactgccaa ggccgtggag
      1210       1220       1230       1240       1250       1260
gtgcagaaca agcccatgat tgaatgggcc ctggggggct tccagccttc tggccctaag
      1270       1280       1290       1300       1310       1320
ggcctggagc caccagaaga agagaagaat ccctacaaag aagtgtacac ggacatgtgg
      1330       1340       1350       1360       1370       1380
gtggaacctg aggcagctgc ctacgcacca cctccaccag ccaaaaagcc ccggaagagc
      1390       1400       1410       1420       1430       1440
acagcggaga agcccaaggt caaggagatt attgatgagc gcacaagaga gcggctggtg
      1450       1460       1470       1480       1490       1500
tacgaggtgc ggcagaagtg ccggaacatt gaggacatct gcatctcctg tgggagcctc
      1510       1520       1530       1540       1550       1560
aatgttaccc tggaacaccc cctcttcgtt ggaggaatgt gccaaaactg caagaactgc
      1570       1580       1590       1600       1610       1620
tttctggagt gtgcgtacca gtacgacgac gacggctacc agtcctactg caccatctgc
      1630       1640       1650       1660       1670       1680
tgtgggggcc gtgaggtgct catgtgcgga aacaacaact gctgcaggtg cttttgcgtg
      1690       1700       1710       1720       1730       1740
gagtgtgtgg acctcttggt ggggccgggg gctgcccagg cagccattaa ggaagacccc
      1750       1760       1770       1780       1790       1800
tggaactgct acatgtgcgg gcacaagggt acctacgggc tgctgcggcg gcgagaggac
      1810       1820       1830       1840       1850       1860
tggccctccc ggctccagat gttcttcgct aataaccacg accaggaatt tgaccctcca
      1870       1880       1890       1900       1910       1920
aaggtttacc cacctgtccc agctgagaag aggaagccca tccgggtgct gtctctcttt
      1930       1940       1950       1960       1970       1980
gatggaatcg ctacagggct cctggtgctg aaggacttgg gcattcaggt ggaccgctac
      1990       2000       2010       2020       2030       2040
attgcctcgg aggtgtgtga ggactccatc acggtgggca tggtgcggca ccaggggaag
      2050       2060       2070       2080       2090       2100
atcatgtacg tcggggacgt ccgcagcgtc acacagaagc atatccagga gtggggccca
      2110       2120       2130       2140       2150       2160
ttcgatctgg tgattggggg cagtccctgc aatgacctct ccatcgtcaa ccctgctcgc
      2170       2180       2190       2200       2210       2220
aagggcctct acgagggcac tggccggctc ttctttgagt tctaccgcct cctgcatgat
      2230       2240       2250       2260       2270       2280
gcgcggccca aggagggaga tgatcgcccc ttcttctggc tctttgagaa tgtggtggcc
      2290       2300       2310       2320       2330       2340
atgggcgtta gtgacaagag ggacatctcg cgatttctcg agtccaaccc tgtgatgatt
      2350       2360       2370       2380       2390       2400
gatgccaaag aagtgtcagc tgcacacagg gcccgctact tctggggtaa ccttcccggt
      2410       2420       2430       2440       2450       2460
atgaacaggc cgttggcatc cactgtgaat gataagctgg agctgcagga gtgtctggag
      2470       2480       2490       2500       2510       2520
catggcagga tagccaagtt cagcaaagtg aggaccatta ctacgaggtc aaactccata
      2530       2540       2550       2560       2570       2580
aagcagggca aagaccagca ttttcctgtc ttcatgaatg agaaagagga catcttatgg
      2590       2600       2610       2620       2630       2640
tgcactgaaa tggaaagggt atttggtttc ccagtccact atactgacgt ctccaacatg
      2650       2660       2670       2680       2690       2700
agccgcttgg cgaggcagag actgctgggc cggtcatgga gcgtgccagt catccgccac
      2710       2720       2730
ctcttcgctc cgctgaagga gtattttgcg tgtgtgtaa  

Last modification date: Oct. 2, 2011