Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: Putative acyl-CoA dehydrogenase AidB


DESCRIPTION:
Part of the adaptive DNA-repair response to alkylating agents. Could prevent alkylation damage by protecting DNA and destroying alkylating agents that have yet to reach their DNA target. Binds to double-stranded DNA with a preference for a DNA region that includes its own promoter. Shows weak isovaleryl-CoA dehydrogenase activity in vitro.
May help to prevent alkylation damage by protecting DNA and destroying alkylating agents.

STRUCTURE SIMILARITY:
Belongs to the acyl-CoA dehydrogenase family.


Amino acids sequence

        10         20         30         40         50         60
MHWQTHTVFN QPIPLNNSNL YLSDGALCEA VTREGAGWDS DFLASIGQQL GTAESLELGR
        70         80         90        100        110        120
LANVNPPELL RYDAQGRRLD DVRFHPAWHL LMQALCTNRV HNLAWEEDAR SGAFVARAAR
       130        140        150        160        170        180
FMLHAQVEAG SLCPITMTFA ATPLLLQMLP APFQDWTTPL LSDRYDSHLL PGGQKRGLLI
       190        200        210        220        230        240
GMGMTEKQGG SDVMSNTTRA ERLEDGSYRL VGHKWFFSVP QSDAHLVLAQ TAGGLSCFFV
       250        260        270        280        290        300
PRFLPDGQRN AIRLERLKDK LGNRSNASCE VEFQDAIGWL LGLEGEGIRL ILKMGGMTRF
       310        320        330        340        350        360
DCALGSHAMM RRAFSLAIYH AHQRHVFGNP LIQQPLMRHV LSRMALQLEG QTALLFRLAR
       370        380        390        400        410        420
AWDRRADAKE ALWARLFTPA AKFVICKRGM PFVAEAMEVL GGIGYCEESE LPRLYREMPV
       430        440        450        460        470        480
NSIWEGSGNI MCLDVLRVLN KQAGVYDLLS EAFVEVKGQD RYFDRAVRRL QQQLRKPAEE
       490        500        510        520        530        540
LGREITHQLF LLGCGAQMLK YASPPMAQAW CQVMLDTRGG VRLSEQIQND LLLRATGGVC

V     

Encoded by aidB gene


OTHER NAME(S):
ECK4183
JW5867


DESCRIPTION:
Induced by anaerobiosis and acetate. [More information is available at EcoGene: EG11811]. AidB is involved in the adaptive DNA-repair response of Escherichia coli to alkylating agents. [More information is available at EcoCyc: EG11811].


Nucleic acid sequence

        10         20         30         40         50         60
gtgcactggc aaactcacac cgtttttaat caacctatac cattaaataa cagcaactta
        70         80         90        100        110        120
tacctgtctg atggcgcgct ctgcgaagcg gtaacgcgtg aaggtgctgg ctgggatagc
       130        140        150        160        170        180
gattttctag ccagtattgg tcagcagtta ggaacggctg aatcccttga actggggcgg
       190        200        210        220        230        240
ctggcgaatg tgaatccgcc tgaattattg cgctacgatg cgcaaggacg ccgtctggac
       250        260        270        280        290        300
gatgtgcgtt ttcaccccgc ctggcacctg ctgatgcagg cgctatgtac caatcgggtg
       310        320        330        340        350        360
cacaatcttg cctgggaaga agacgctcgc tccggcgcat ttgtggcgcg cgcggcgcgt
       370        380        390        400        410        420
tttatgttac atgcgcaggt tgaggcaggg tcgttatgtc cgataaccat gacctttgcc
       430        440        450        460        470        480
gccacgccat tgttgttaca gatgttaccc gcgccgtttc aggactggac cacgccgcta
       490        500        510        520        530        540
ttgagcgatc gctacgattc tcacttattg ccaggtgggc aaaaacgcgg tttgttgatt
       550        560        570        580        590        600
ggcatgggaa tgacggaaaa gcagggcggt tccgatgtta tgagcaacac cacccgtgca
       610        620        630        640        650        660
gagcgtctgg aagatggctc ttatcggctg gtggggcata aatggttttt ctcggttccg
       670        680        690        700        710        720
caaagcgatg cgcatctggt gctggcgcag accgcgggtg gtctgtcctg cttttttgtg
       730        740        750        760        770        780
ccgcgctttt tgcctgacgg gcaacgcaac gcgattcgcc tcgagcggct gaaagataag
       790        800        810        820        830        840
ctgggtaatc gctctaacgc cagttgcgaa gtggagtttc aggatgccat tggttggttg
       850        860        870        880        890        900
ttggggctgg aaggggaagg aattcgtctg atcctgaaaa tgggtgggat gacgcgtttt
       910        920        930        940        950        960
gattgcgccc tgggtagcca tgccatgatg cgccgtgcat tttcgctggc gatttatcat
       970        980        990       1000       1010       1020
gcacatcaac gccatgtttt tggtaatcca ttgatccaac agccccttat gcgtcatgtc
      1030       1040       1050       1060       1070       1080
ttaagtcgca tggcacttca gcttgaaggg caaacggcgt tgctgtttcg tcttgcgcga
      1090       1100       1110       1120       1130       1140
gcgtgggacc ggcgtgccga tgccaaagaa gccctgtggg cgcgtttatt tacgcctgcg
      1150       1160       1170       1180       1190       1200
gcaaaatttg tgatctgcaa aagaggtatg ccgtttgtgg ccgaagcgat ggaggtgctg
      1210       1220       1230       1240       1250       1260
ggcggcattg gttattgcga ggagagtgag ctgccgcggc tttaccggga gatgccggta
      1270       1280       1290       1300       1310       1320
aacagtattt gggaaggttc cggcaatatt atgtgcctgg atgtgttgcg cgttctcaat
      1330       1340       1350       1360       1370       1380
aagcaagcgg gcgtatacga cttattgtcg gaagcatttg tggaagtgaa agggcaggat
      1390       1400       1410       1420       1430       1440
cgctattttg atcgcgcggt tcgtcgttta cagcagcagc tgcgtaagcc agctgaagaa
      1450       1460       1470       1480       1490       1500
ctggggcgag agattactca tcagctattc ctgctgggct gcggtgcgca aatgttgaaa
      1510       1520       1530       1540       1550       1560
tatgcttctc cgccaatggc gcaggcgtgg tgtcaggtga tgttagatac gcgcggcggc
      1570       1580       1590       1600       1610       1620
gtacggttgt cagagcagat ccagaatgat ttattgctgc gggcgacggg gggagtgtgt

gtgtaa     

Last modification date: Oct. 2, 2011