Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: Protein umuD


DESCRIPTION:
Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template.

STRUCTURE SIMILARITY:
Belongs to the peptidase S24 family.


PROTEIN TYPE(S):
accessory protein


RELATED PATHWAY(S):
translesion synthesis (TLS)
prokaryotic (SOS) response


Amino acids sequence

        10         20         30         40         50         60
MLFIKPADLR EIVTFPLFSD LVQCGFPSPA ADYVEQRIDL NQLLIQHPSA TYFVKASGDS
        70         80         90        100        110        120
MIDGGISDGD LLIVDSAITA SHGDIVIAAV DGEFTVKKLQ LRPTVQLIPM NSAYSPITIS
       130
SEDTLDVFGV VIHVVKAMR    

Encoded by umuD gene


OTHER NAME(S):
ECK1171
JW1172


DESCRIPTION:
LexA regulon. [More information is available at EcoGene: EG11057]. Following induction of the SOS response, UmuD is proteolytically processed into UmuD' in a cleavage reaction that depends on activated RecA . [More information is available at EcoCyc: EG11057].


Nucleic acid sequence

        10         20         30         40         50         60
atgttgttta tcaagcctgc ggatctccgc gaaattgtga cttttccgct atttagcgat
        70         80         90        100        110        120
cttgttcagt gtggctttcc ttcaccggca gcagattacg ttgaacagcg catcgatctg
       130        140        150        160        170        180
aatcaactgt tgatccagca tcccagcgcg acttacttcg tcaaagcaag tggtgattct
       190        200        210        220        230        240
atgattgatg gtggaattag tgacggtgat ttactgattg tcgatagcgc tattaccgcc
       250        260        270        280        290        300
agccatggtg atattgtcat cgctgctgtt gacggcgagt ttacggtgaa aaaattgcaa
       310        320        330        340        350        360
ctacgcccga cggtacagct tattcccatg aacagcgcgt actcgcccat taccatcagt
       370        380        390        400        410        420
agtgaagata cgctggatgt ctttggtgtg gtgatccacg tcgttaaggc gatgcgctga

Last modification date: Oct. 2, 2011