Escherichia coli Migula (bacterium) K-12 MG1655 [ECO]

FULL NAME: Protein umuC


DESCRIPTION:
Involved in UV protection and mutation. Essential for induced (or SOS) mutagenesis. May modify the DNA replication machinery to allow bypass synthesis across a damaged template.

STRUCTURE SIMILARITY:
Belongs to the DNA polymerase type-Y family.
Contains 1 umuC domain.


PROTEIN TYPE(S):
Y-family DNA polymerase


RELATED PATHWAY(S):
translesion synthesis (TLS)
prokaryotic (SOS) response


Amino acids sequence

        10         20         30         40         50         60
MFALCDVNAF YASCETVFRP DLWGKPVVVL SNNDGCVIAR NAEAKALGVK MGDPWFKQKD
        70         80         90        100        110        120
LFRRCGVVCF SSNYELYADM SNRVMSTLEE LSPRVEIYSI DEAFCDLTGV RNCRDLTDFG
       130        140        150        160        170        180
REIRATVLQR THLTVGVGIA QTKTLAKLAN HAAKKWQRQT GGVVDLSNLE RQRKLMSALP
       190        200        210        220        230        240
VDDVWGIGRR ISKKLDAMGI KTVLDLADTD IRFIRKHFNV VLERTVRELR GEPCLQLEEF
       250        260        270        280        290        300
APTKQEIICS RSFGERITDY PSMRQAICSY AARAAEKLRS EHQYCRFIST FIKTSPFALN
       310        320        330        340        350        360
EPYYGNSASV KLLTPTQDSR DIINAATRSL DAIWQAGHRY QKAGVMLGDF FSQGVAQLNL
       370        380        390        400        410        420
FDDNAPRPGS EQLMTVMDTL NAKEGRGTLY FAGQGIQQQW QMKRAMLSPR YTTRSSDLLR

VK     

Encoded by umuC gene


OTHER NAME(S):
ECK1172
JW1173
uvm


DESCRIPTION:
ATPgammaS inhibits UmuC activity. [More information is available at EcoGene: EG11056]. The chaperones Hsp70 (DnaK) and Hsp60 (MopA) help fold UmuC into its functional form . [More information is available at EcoCyc: EG11056].


Nucleic acid sequence

        10         20         30         40         50         60
atgtttgccc tctgtgatgt aaacgcgttt tatgccagct gtgagacggt gtttcgccct
        70         80         90        100        110        120
gatttatggg gtaaaccggt ggttgtgcta tcgaataatg acggttgcgt tatcgcccga
       130        140        150        160        170        180
aacgctgagg caaaggcgct tggcgttaaa atgggcgatc cctggttcaa acaaaaagat
       190        200        210        220        230        240
ctgtttcgtc gctgtggcgt ggtttgcttt agcagcaatt atgagcttta cgcagacatg
       250        260        270        280        290        300
agcaatcggg tgatgtcgac gctggaagag ctatcgcccc gcgtcgagat ttacagtatt
       310        320        330        340        350        360
gatgaggcat tctgcgatct gacaggtgtg cgtaattgtc gcgatctgac tgattttggc
       370        380        390        400        410        420
agagaaattc gcgcaacggt gctacaacgt acccatctta ctgttggtgt ggggatcgcc
       430        440        450        460        470        480
cagaccaaaa cgctggctaa gcttgccaat catgcggcaa aaaaatggca gcggcagacg
       490        500        510        520        530        540
ggtggggtgg tggatttatc aaatctggaa cgccagcgta aattaatgtc tgctctcccc
       550        560        570        580        590        600
gtggatgacg tctgggggat tggacggcgg atcagcaaaa aactggacgc gatggggatc
       610        620        630        640        650        660
aaaaccgttc tcgatttggc ggatacagat atccggttta tccgtaaaca ttttaatgtc
       670        680        690        700        710        720
gtgctcgaaa gaacggtgcg tgaactgcgc ggcgaaccct gtttgcaact ggaagagttt
       730        740        750        760        770        780
gcaccgacga agcaggaaat tatctgttcc cgctcgtttg gtgaacgcat cacggattat
       790        800        810        820        830        840
ccgtcgatgc ggcaggccat ttgtagttac gctgcccggg cggcggaaaa acttcgcagc
       850        860        870        880        890        900
gagcatcaat attgtcggtt tatctccacg tttattaaga cgtcaccatt tgcgctcaat
       910        920        930        940        950        960
gaaccttatt acggcaatag cgcgtcggta aaactgctga cgcccactca ggacagcagg
       970        980        990       1000       1010       1020
gatatcatta acgctgctac gcgatctctg gatgccatct ggcaagcggg ccatcgttac
      1030       1040       1050       1060       1070       1080
caaaaagcgg gcgtgatgct gggggatttc ttcagtcagg gagtcgcgca gctcaattta
      1090       1100       1110       1120       1130       1140
ttcgatgaca acgcaccgcg ccccgggagt gagcaattga tgacggtaat ggatacactg
      1150       1160       1170       1180       1190       1200
aatgctaaag agggcagagg aacactctat tttgccgggc aggggatcca gcaacaatgg
      1210       1220       1230       1240       1250       1260
cagatgaagc gagccatgct ttcaccacgt tatacaacgc gaagttctga tttactgagg

gtcaaataa     

Last modification date: Oct. 2, 2011