Homo sapiens L. (human) [HSA]

FULL NAME: Probable crossover junction endonuclease EME2


DESCRIPTION:
Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures.

STRUCTURE SIMILARITY:
Belongs to the EME1/MMS4 family.


PROTEIN TYPE(S):
endonuclease


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway


Amino acids sequence

        10         20         30         40         50         60
MARVGPGRAG VSCQGRGRGR GGSGQRRPPT WEISDSDAED SAGSEAAARA RDPAGERRAA
        70         80         90        100        110        120
AEALRLLRPE QVLKRLAVCV DTAILEDAGA DVLMEALEAL GCECRIEPQR PARSLRWTRA
       130        140        150        160        170        180
SPDPCPRSLP PEVWAAGEQE LLLLLEPEEF LQGVATLTQI SGPTHWVPWI SPETTARPHL
       190        200        210        220        230        240
AVIGLDAYLW SRQHVSRGTQ QPESPKVAGA EVAVSWPEVE EVRACLSWAL VLLQLWANLD
       250        260        270        280        290        300
VLLVASWQEL SRHVCAVTKA LAQYPLKGGR ITSRQYRESQ AFSFCTAGRW AAGEPVARDG
       310        320        330        340        350        360
AGLQAAWRRQ IRQFSRVSPA VADAVVTAFP SPRLLQQALE ACSTERERMG LLAVGPDLSR
       370
RICLFLTTAN PDLLLDLGS    

Encoded by EME2 gene

FULL NAME: essential meiotic endonuclease 1 homolog 2 (S. pombe)


OTHER NAME(S):
FLJ00151
SLX2B
gs125


DESCRIPTION:
EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggcgcggg ttggacccgg gagggcgggg gtctcttgcc agggccgggg ccggggacgg
        70         80         90        100        110        120
ggcgggagcg gtcagcggcg acctccaacc tgggagatct cagactccga cgctgaggac
       130        140        150        160        170        180
tccgccggct cggaggccgc cgcgagagcc cgggacccag cgggtgagcg cagggcggct
       190        200        210        220        230        240
gccgaggcgt tgcggctgct gcggccggag caggtgctga agcgcctcgc ggtgtgcgtg
       250        260        270        280        290        300
gacacagcca tcctggaaga cgccggtgcc gacgtcctga tggaggccct ggaggccctg
       310        320        330        340        350        360
ggctgcgagt gccgcatcga gccccagcgc ccggcccgca gcctgcggtg gacccgagcg
       370        380        390        400        410        420
agtcccgacc cctgcccccg cagcctgcct cctgaagtgt gggctgcagg tgaacaggaa
       430        440        450        460        470        480
ttgctgctgc tgctggagcc cgaggagttt ctgcagggcg tcgccacact gacccagatc
       490        500        510        520        530        540
tctggcccaa cccactgggt gccctggatc tcccccgaga ccaccgcccg gccccacctg
       550        560        570        580        590        600
gctgtcatcg ggctggatgc ctacctgtgg taccgctcac tctcatgccc acagcagggc
       610        620        630        640        650        660
tggctgggac gggggttcag gggaggtggg ctctggcaga ggccaagctc gggcagggca
       670        680        690        700        710        720
ggccccatgg ggagcgggga ggaatggtca cctctgctca ggtctcgcca gcacgtttcc
       730        740        750        760        770        780
cgggggacac agcagccaga gagcccgaag gtggccggtg ccgaggtggc cgtcagctgg
       790        800        810        820        830        840
ccggaggtgg aagaggtgag ggcctgtctg agctgggccc tggtactcct gcagctctgg
       850        860        870        880        890        900
gcaaacctgg acgtgctact ggtggcctct tggcaggagc tgagtcggca cgtgtgcgcc
       910        920        930        940        950        960
gttaccaagg ctctcgccca gtatcccctc aagtgcgtga tgccaaggct gaaggggggc
       970        980        990       1000       1010       1020
aggatcacct caaggcagta ccgggaatcc caggccttct ccttctgcac agcagggcgc
      1030       1040       1050       1060       1070       1080
tgggcagccg gcgagccagt ggcaagagac ggcgcagggc tgcaggcggc ctggcggagg
      1090       1100       1110       1120       1130       1140
cagatcaggc agttcagtcg ggtcagccca gccgtggctg atgcagttgt cacagccttc
      1150       1160       1170       1180       1190       1200
ccctcccccc gccttctgca gcaggcgctg gaggcctgca gcacggagcg ggagcgcatg
      1210       1220       1230       1240       1250       1260
ggcctcctgg ccgaccttcc tgtgccgccc agtgaaggcg ggcgtccccg cagggtgggg
      1270       1280       1290       1300       1310       1320
cctgacctct cccgccgcat ctgcctcttc ctgaccacag ccaaccctga tctcctgctg
      1330
gacctgggct cctga    

Last modification date: Oct. 2, 2011