Homo sapiens L. (human) [HSA]

FULL NAME: DNA primase large subunit


DESCRIPTION:
DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.

STRUCTURE SIMILARITY:
Belongs to the eukaryotic-type primase large subunit family.


RELATED PATHWAY(S):
DNA replication


Amino acids sequence

        10         20         30         40         50         60
MEFSGRKWRK LRLAGDQRNA SYPHCLQFYL QPPSENISLI EFENLAIDRV KLLKSVENLG
        70         80         90        100        110        120
VSYVKGTEQY QSKLESELRK LKFSYRENLE DEYEPRRRDH ISHFILRLAY CQSEELRRWF
       130        140        150        160        170        180
IQQEMDLLRF RFSILPKDKI QDFLKDSQLQ FEAISDEEKT LREQEIVASS PSLSGLKLGF
       190        200        210        220        230        240
ESIYKIPFAD ALDLFRGRKV YLEDGFAYVP LKDIVAIILN EFRAKLSKAL ALTARSLPAV
       250        260        270        280        290        300
QSDERLQPLL NHLSHSYTGQ DYSTQGNVGK ISLDQIDLLS TKSFPPCMRQ LHKALRENHH
       310        320        330        340        350        360
LRHGGRMQYG LFLKGIGLTL EQALQFWKQE FIKGKMDPDK FDKGYSYNIR HSFGKEGKRT
       370        380        390        400        410        420
DYTPFSCLKI ILSNPPSQGD YHGCPFRHSD PELLKQKLQS YKISPGGISQ ILDLVKGTHY
       430        440        450        460        470        480
QVACQKYFEM IHNVDDCGFS LNHPNQFFCE SQRILNGGKD IKKEPIQPET PQPKPSVQKT
       490        500
KDASSALASL NSSLEMDMEG LEDYFSEDS   

Encoded by PRIM2 gene

FULL NAME: primase, DNA, polypeptide 2 (58kDa)


OTHER NAME(S):
MGC75142
PRIM2A
p58


DESCRIPTION:
The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggagtttt ctggaagaaa gtggaggaag ctgaggttgg caggtgacca gaggaatgct
        70         80         90        100        110        120
tcctaccctc attgccttca gttttacttg cagccacctt ctgaaaacat atctttaata
       130        140        150        160        170        180
gaatttgaaa acttggctat tgatagagtt aaattgttaa aatcagttga aaatcttgga
       190        200        210        220        230        240
gtgagctatg tgaaaggaac tgaacaatac cagagtaagt tggagagtga gcttcggaag
       250        260        270        280        290        300
ctcaagtttt cctacagaga aaacttagaa gatgaatatg aaccacgaag aagagatcat
       310        320        330        340        350        360
atttctcatt ttattttgcg gcttgcttat tgccagtctg aagaacttag acgctggttc
       370        380        390        400        410        420
attcaacaag aaatggatct ccttcgattt agatttagta ttttacccaa ggataaaatt
       430        440        450        460        470        480
caggatttct taaaggatag ccaattgcag tttgaggcta taagtgatga agagaagact
       490        500        510        520        530        540
cttcgagaac aggagattgt tgcctcatca ccaagtttaa gtggacttaa gttggggttc
       550        560        570        580        590        600
gagtccattt ataagatccc ttttgctgat gctctggatt tgtttcgagg aaggaaagtc
       610        620        630        640        650        660
tatttggaag atggctttgc ttacgtacca cttaaggaca ttgtggcaat catcctgaat
       670        680        690        700        710        720
gaatttagag ccaaactgtc caaggctttg gcattaacag ccaggtcctt gcctgctgtg
       730        740        750        760        770        780
cagtctgatg aaagacttca gcctctgctc aatcacctca gtcattccta cactggccaa
       790        800        810        820        830        840
gattacagta cccagggaaa tgttgggaag atttctttag atcagattga tttgctttct
       850        860        870        880        890        900
accaaatcct tcccaccttg catgcgtcag ttacataaag ccttgcggga aaatcaccat
       910        920        930        940        950        960
cttcgtcatg gaggccgaat gcagtatggc ctatttctga agggcattgg tttaactttg
       970        980        990       1000       1010       1020
gaacaggcat tgcagttctg gaagcaagaa tttatcaaag gaaagatgga tccagacaag
      1030       1040       1050       1060       1070       1080
tttgataaag gttactctta caacatccgt cacagctttg gaaaggaagg caagaggaca
      1090       1100       1110       1120       1130       1140
gactatacac ctttcagttg cctgaagatt attctgtcca atccaccaag ccaaggggat
      1150       1160       1170       1180       1190       1200
tatcatgggt gcccattccg tcacagtgat ccagagctgc tgaagcaaaa gttgcagtca
      1210       1220       1230       1240       1250       1260
tacaagatct ctcctggagg gataagccag attttggatt tagtaaaggg gacacattac
      1270       1280       1290       1300       1310       1320
caggtagcct gtcaaaaata ctttgagatg atacacaatg tggatgattg tggcttttct
      1330       1340       1350       1360       1370       1380
ttgaatcatc ctaatcagtt cttttgtgag agccaacgta ttctaaatgg tggtaaagac
      1390       1400       1410       1420       1430       1440
ataaagaagg aacctatcca accagaaact cctcaaccca aaccaagtgt ccagaaaacc
      1450       1460       1470       1480       1490       1500
aaggatgcat catctgctct ggcctcttta aattcctctc tggaaatgga tatggaagga
      1510       1520       1530
ctagaagatt actttagtga agattcttag   

Last modification date: Oct. 2, 2011