Homo sapiens L. (human) [HSA]

FULL NAME: ATR-interacting protein


DESCRIPTION:
Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.

STRUCTURE SIMILARITY:
Belongs to the ATRIP family.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated by ATR.


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway
DNA damage response (DDR)


Amino acids sequence

        10         20         30         40         50         60
MAGTSAPGSK RRSEPPAPRP GPPPGTGHPP SKRARGFSAA AAPDPDDPFG AHGDFTADDL
        70         80         90        100        110        120
EELDTLASQA LSQCPAAARD VSSDHKVHRL LDGMSKNPSG KNRETVPIKD NFELEVLQAQ
       130        140        150        160        170        180
YKELKEKMKV MEEEVLIKNG EIKILRDSLH QTESVLEEQR RSHFLLEQEK TQALSDKEKE
       190        200        210        220        230        240
FSKKLQSLQS ELQFKDAEMN ELRTKLQTSE RANKLAAPSV SHVSPRKNPS VVIKPEACSP
       250        260        270        280        290        300
QFGKTSFPTK ESFSANMSLP HPCQTESGYK PLVGREDSKP HSLRGDSIKQ EEAQKSFVDS
       310        320        330        340        350        360
WRQRSNTQGS ILINLLLKQP LIPGSSLSLC HLLSSSSESP AGTPLQPPGF GSTLAGMSGL
       370        380        390        400        410        420
RTTGSYDGSF SLSALREAQN LAFTGLNLVA RNECSRDGDP AEGGRRAFPL CQLPGAVHFL
       430        440        450        460        470        480
PLVQFFIGLH CQALQDLAAA KRSGAPGDSP THSSCVSSGV ETNPEDSVCI LEGFSVTALS
       490        500        510        520        530        540
ILQHLVCHSG AVVSLLLSGV GADSAAGEGN RSLVHRLSDG DMTSALRGVA DDQGQHPLLK
       550        560        570        580        590        600
MLLHLLAFSS AATGHLQASV LTQCLKVLVK LAENTSCDFL PRFQCVFQVL PKCLSPETPL
       610        620        630        640        650        660
PSVLLAVELL SLLADHDQLA PQLCSHSEGC LLLLLYMYIT SRPDRVALET QWLQLEQEVV
       670        680        690        700        710        720
WLLAKLGVQS PLPPVTGSNC QCNVEVVRAL TVMLHRQWLT VRRAGGPPRT DQQRRTVRCL
       730        740        750        760        770        780
RDTVLLLHGL SQKDKLFMMH CVEVLHQFDQ VMPGVSMLIR GLPDVTDCEE AALDDLCAAE
       790
TDVEDPEVEC G    

Encoded by ATRIP gene

FULL NAME: ATR interacting protein


OTHER NAME(S):
DKFZp762J2115
FLJ12343
MGC20625
MGC21482
MGC26740


DESCRIPTION:
The product of this gene is an essential component of the DNA damage checkpoint, and binds to single-stranded DNA coated with replication protein A that accumulates at sites of DNA damage. The encoded protein interacts with the ataxia telangiectasia and Rad3 related protein, a checkpoint kinase, resulting in accumulation of the kinase at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggcgggga cctccgcgcc aggcagcaag aggcggagcg agcccccggc gcctcgcccc
        70         80         90        100        110        120
ggcccgccgc cgggcaccgg gcaccccccg agcaagcggg cccggggctt ctccgcagcc
       130        140        150        160        170        180
gctgccccgg accctgacga cccgttcggc gcgcatgggg acttcactgc cgacgacctg
       190        200        210        220        230        240
gaggagcttg acaccctcgc gtcacaggcc ctgagccaat gtccggccgc ggctcgggac
       250        260        270        280        290        300
gtgtccagtg atcataaggt ccacagatta ttagatggca tgtcaaaaaa tccttcaggg
       310        320        330        340        350        360
aaaaacagag aaactgttcc aattaaagat aatttcgaat tagaggtact tcaggcacaa
       370        380        390        400        410        420
tacaaagaac ttaaagaaaa gatgaaagta atggaagaag aagttctcat taagaatgga
       430        440        450        460        470        480
gaaattaaaa ttttgcgaga ctcactacat cagacggaat ccgttctaga ggaacagaga
       490        500        510        520        530        540
agatcacatt ttcttcttga gcaagagaaa acccaagcac tcagtgacaa ggaaaaggaa
       550        560        570        580        590        600
ttctccaaaa agctccaatc attgcagtct gaactccagt ttaaagatgc agagatgaat
       610        620        630        640        650        660
gaattaagga caaagctcca gaccagtgaa cgagcaaata aactggctgc tccctctgtt
       670        680        690        700        710        720
tcccatgtca gtcctaggaa aaacccttct gtggttataa agccagaagc atgttctcca
       730        740        750        760        770        780
caatttggaa aaacatcttt tcctacaaag gagtctttta gtgctaacat gtcccttccc
       790        800        810        820        830        840
cacccctgcc agacggagtc aggatacaag cctctggtgg gcagagagga tagtaagccc
       850        860        870        880        890        900
cacagtctga gaggtgactc cataaaacaa gaagaggccc agaaaagctt tgttgacagc
       910        920        930        940        950        960
tggagacaga gatcaaacac tcaaggttcc attttgataa acctgctcct gaagcagcct
       970        980        990       1000       1010       1020
ttgatcccag ggtcatccct aagcctttgc cacctcctga gtagtagttc tgagtctcct
      1030       1040       1050       1060       1070       1080
gctggcaccc ccctgcagcc accagggttt ggcagtacct tggctggaat gtcaggcctc
      1090       1100       1110       1120       1130       1140
aggaccacag gttcttatga tgggtcattt tccctctcag ccctgagaga agcacagaac
      1150       1160       1170       1180       1190       1200
ctggcattca ctggactgaa tctggttgcc cggaatgagt gctcacgtga tggagaccca
      1210       1220       1230       1240       1250       1260
gcagagggag gcagaagggc cttcccactc tgccagcttc ctggagccgt gcatttcctc
      1270       1280       1290       1300       1310       1320
ccccttgtac agttcttcat cggcttacac tgccaggccc tgcaggactt ggcagctgct
      1330       1340       1350       1360       1370       1380
aagagaagcg gagcacctgg ggactcaccg acacattcct cctgcgtgag ctctggggta
      1390       1400       1410       1420       1430       1440
gagaccaacc ctgaggactc agtgtgcatc ctggaaggct tctctgtgac tgcacttagc
      1450       1460       1470       1480       1490       1500
attcttcagc acctggtgtg ccacagcgga gcagtcgtct ccctattact gtcaggagtg
      1510       1520       1530       1540       1550       1560
ggggcagatt ctgctgctgg ggaaggaaac aggagcctgg ttcacaggct tagtgatgga
      1570       1580       1590       1600       1610       1620
gatatgacct cagccctaag gggggttgct gatgaccaag gacagcaccc actgttgaag
      1630       1640       1650       1660       1670       1680
atgcttcttc acctgttggc tttctcttct gcagcaacag gtcaccttca agccagtgtc
      1690       1700       1710       1720       1730       1740
ctgacccagt gccttaaggt tttggtgaaa ttagccgaaa acacttcctg tgatttcttg
      1750       1760       1770       1780       1790       1800
cccaggttcc agtgtgtgtt ccaagtgctg ccaaagtgcc tcagcccaga gacacccctg
      1810       1820       1830       1840       1850       1860
cctagcgtgc tgctggctgt tgagctcctc tccctgctgg cggaccacga ccagctggca
      1870       1880       1890       1900       1910       1920
cctcagctct gttcccactc agaaggctgc ctcctgctgc tgctgtacat gtacatcaca
      1930       1940       1950       1960       1970       1980
tcacggcctg acagagtggc cttggagaca caatggctcc agctggaaca agaggtggtc
      1990       2000       2010       2020       2030       2040
agagcgctca cggtgatgtt gcacagacag tggctgacag tgcggagggc agggggaccc
      2050       2060       2070       2080       2090       2100
ccaaggaccg accagcagag gcggacagtg cgctgtctgc gggacacggt gctgctgctg
      2110       2120       2130       2140       2150       2160
cacggcctat cgcagaagga caagctcttc atgatgcact gcgtggaggt cctgcatcag
      2170       2180       2190       2200       2210       2220
tttgaccagg tgatgccggg ggtcagcatg ctcatccgag ggcttcctga tgtgacggac
      2230       2240       2250       2260       2270       2280
tgtgaagagg cagccctgga tgacctctgt gccgcggaaa ccgatgtgga agaccccgag
      2290
gtggagtgtg gctga    

Last modification date: Oct. 2, 2011