Homo sapiens L. (human) [HSA]

FULL NAME: Serine/threonine-protein kinase ATR


DESCRIPTION:
Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

STRUCTURE SIMILARITY:
Belongs to the PI3/PI4-kinase family. ATM subfamily.
Contains 1 FATC domain.
Contains 1 PI3K/PI4K domain.
Contains 2 HEAT repeats.
Contains 1 FAT domain.


CATALYTIC ACTIVITY:
ATP + a protein = ADP + a phosphoprotein.


ENZYME REGULATION:
Activated by DNA and inhibited by BCR-ABL oncogene. Slightly activated by ATRIP. Inhibited by caffeine, wortmannin and LY294002.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated; autophosphorylates in vitro.


PROTEIN TYPE(S):
kinase


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway
DNA damage response (DDR)


RELATED DISEASE(S):
Seckel syndrome 1 (SCKL1)


Amino acids sequence

        10         20         30         40         50         60
MGEHGLELAS MIPALRELGS ATPEEYNTVV QKPRQILCQF IDRILTDVNV VAVELVKKTD
        70         80         90        100        110        120
SQPTSVMLLD FIQHIMKSSP LMFVNVSGSH EAKGSCIEFS NWIITRLLRI AATPSCHLLH
       130        140        150        160        170        180
KKICEVICSL LFLFKSKSPA IFGVLTKELL QLFEDLVYLH RRNVMGHAVE WPVVMSRFLS
       190        200        210        220        230        240
QLDEHMGYLQ SAPLQLMSMQ NLEFIEVTLL MVLTRIIAIV FFRRQELLLW QIGCVLLEYG
       250        260        270        280        290        300
SPKIKSLAIS FLTELFQLGG LPAQPASTFF SSFLELLKHL VEMDTDQLKL YEEPLSKLIK
       310        320        330        340        350        360
TLFPFEAEAY RNIEPVYLNM LLEKLCVMFE DGVLMRLKSD LLKAALCHLL QYFLKFVPAG
       370        380        390        400        410        420
YESALQVRKV YVRNICKALL DVLGIEVDAE YLLGPLYAAL KMESMEIIEE IQCQTQQENL
       430        440        450        460        470        480
SSNSDGISPK RRRLSSSLNP SKRAPKQTEE IKHVDMNQKS ILWSALKQKA ESLQISLEYS
       490        500        510        520        530        540
GLKNPVIEML EGIAVVLQLT ALCTVHCSHQ NMNCRTFKDC QHKSKKKPSV VITWMSLDFY
       550        560        570        580        590        600
TKVLKSCRSL LESVQKLDLE ATIDKVVKIY DALIYMQVNS SFEDHILEDL CGMLSLPWIY
       610        620        630        640        650        660
SHSDDGCLKL TTFAANLLTL SCRISDSYSP QAQSRCVFLL TLFPRRIFLE WRTAVYNWAL
       670        680        690        700        710        720
QSSHEVIRAS CVSGFFILLQ QQNSCNRVPK ILIDKVKDDS DIVKKEFASI LGQLVCTLHG
       730        740        750        760        770        780
MFYLTSSLTE PFSEHGHVDL FCRNLKATSQ HECSSSQLKA SVCKPFLFLL KKKIPSPVKL
       790        800        810        820        830        840
AFIDNLHHLC KHLDFREDET DVKAVLGTLL NLMEDPDKDV RVAFSGNIKH ILESLDSEDG
       850        860        870        880        890        900
FIKELFVLRM KEAYTHAQIS RNNELKDTLI LTTGDIGRAA KGDLVPFALL HLLHCLLSKS
       910        920        930        940        950        960
ASVSGAAYTE IRALVAAKSV KLQSFFSQYK KPICQFLVES LHSSQMTALP NTPCQNADVR
       970        980        990       1000       1010       1020
KQDVAHQREM ALNTLSEIAN VFDFPDLNRF LTRTLQVLLP DLAAKASPAA SALIRTLGKQ
      1030       1040       1050       1060       1070       1080
LNVNRREILI NNFKYIFSHL VCSCSKDELE RALHYLKNET EIELGSLLRQ DFQGLHNELL
      1090       1100       1110       1120       1130       1140
LRIGEHYQQV FNGLSILASF ASSDDPYQGP RDIISPELMA DYLQPKLLGI LAFFNMQLLS
      1150       1160       1170       1180       1190       1200
SSVGIEDKKM ALNSLMSLMK LMGPKHVSSV RVKMMTTLRT GLRFKDDFPE LCCRAWDCFV
      1210       1220       1230       1240       1250       1260
RCLDHACLGS LLSHVIVALL PLIHIQPKET AAIFHYLIIE NRDAVQDFLH EIYFLPDHPE
      1270       1280       1290       1300       1310       1320
LKKIKAVLQE YRKETSESTD LQTTLQLSMK AIQHENVDVR IHALTSLKET LYKNQEKLIK
      1330       1340       1350       1360       1370       1380
YATDSETVEP IISQLVTVLL KGCQDANSQA RLLCGECLGE LGAIDPGRLD FSTTETQGKD
      1390       1400       1410       1420       1430       1440
FTFVTGVEDS SFAYGLLMEL TRAYLAYADN SRAQDSAAYA IQELLSIYDC REMETNGPGH
      1450       1460       1470       1480       1490       1500
QLWRRFPEHV REILEPHLNT RYKSSQKSTD WSGVKKPIYL SKLGSNFAEW SASWAGYLIT
      1510       1520       1530       1540       1550       1560
KVRHDLASKI FTCCSIMMKH DFKVTIYLLP HILVYVLLGC NQEDQQEVYA EIMAVLKHDD
      1570       1580       1590       1600       1610       1620
QHTINTQDIA SDLCQLSTQT VFSMLDHLTQ WARHKFQALK AEKCPHSKSN RNKVDSMVST
      1630       1640       1650       1660       1670       1680
VDYEDYQSVT RFLDLIPQDT LAVASFRSKA YTRAVMHFES FITEKKQNIQ EHLGFLQKLY
      1690       1700       1710       1720       1730       1740
AAMHEPDGVA GVSAIRKAEP SLKEQILEHE SLGLLRDATA CYDRAIQLEP DQIIHYHGVV
      1750       1760       1770       1780       1790       1800
KSMLGLGQLS TVITQVNGVH ANRSEWTDEL NTYRVEAAWK LSQWDLVENY LAADGKSTTW
      1810       1820       1830       1840       1850       1860
SVRLGQLLLS AKKRDITAFY DSLKLVRAEQ IVPLSAASFE RGSYQRGYEY IVRLHMLCEL
      1870       1880       1890       1900       1910       1920
EHSIKPLFQH SPGDSSQEDS LNWVARLEMT QNSYRAKEPI LALRRALLSL NKRPDYNEMV
      1930       1940       1950       1960       1970       1980
GECWLQSARV ARKAGHHQTA YNALLNAGES RLAELYVERA KWLWSKGDVH QALIVLQKGV
      1990       2000       2010       2020       2030       2040
ELCFPENETP PEGKNMLIHG RAMLLVGRFM EETANFESNA IMKKYKDVTA CLPEWEDGHF
      2050       2060       2070       2080       2090       2100
YLAKYYDKLM PMVTDNKMEK QGDLIRYIVL HFGRSLQYGN QFIYQSMPRM LTLWLDYGTK
      2110       2120       2130       2140       2150       2160
AYEWEKAGRS DRVQMRNDLG KINKVITEHT NYLAPYQFLT AFSQLISRIC HSHDEVFVVL
      2170       2180       2190       2200       2210       2220
MEIIAKVFLA YPQQAMWMMT AVSKSSYPMR VNRCKEILNK AIHMKKSLEK FVGDATRLTD
      2230       2240       2250       2260       2270       2280
KLLELCNKPV DGSSSTLSMS THFKMLKKLV EEATFSEILI PLQSVMIPTL PSILGTHANH
      2290       2300       2310       2320       2330       2340
ASHEPFPGHW AYIAGFDDMV EILASLQKPK KISLKGSDGK FYIMMCKPKD DLRKDCRLME
      2350       2360       2370       2380       2390       2400
FNSLINKCLR KDAESRRREL HIRTYAVIPL NDECGIIEWV NNTAGLRPIL TKLYKEKGVY
      2410       2420       2430       2440       2450       2460
MTGKELRQCM LPKSAALSEK LKVFREFLLP RHPPIFHEWF LRTFPDPTSW YSSRSAYCRS
      2470       2480       2490       2500       2510       2520
TAVMSMVGYI LGLGDRHGEN ILFDSLTGEC VHVDFNCLFN KGETFEVPEI VPFRLTHNMV
      2530       2540       2550       2560       2570       2580
NGMGPMGTEG LFRRACEVTM RLMRDQREPL MSVLKTFLHD PLVEWSKPVK GHSKAPLNET
      2590       2600       2610       2620       2630       2640
GEVVNEKAKT HVLDIEQRLQ GVIKTRNRVT GLPLSIEGHV HYLIQEATDE NLLCQMYLGW

TPYM     

Encoded by ATR gene

FULL NAME: ataxia telangiectasia and Rad3 related


OTHER NAME(S):
FRP1
MEC1
SCKL
SCKL1


DESCRIPTION:
The protein encoded by this gene belongs the PI3/PI4-kinase family, and is most closely related to ATM, a protein kinase encoded by the gene mutated in ataxia telangiectasia. This protein and ATM share similarity with Schizosaccharomyces pombe rad3, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This kinase has been shown to phosphorylate checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. Mutations of this gene are associated with Seckel syndrome. An alternatively spliced transcript variant of this gene has been reported, however, its full length nature is not known. Transcript variants utilizing alternative polyA sites exist. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgggggaac atggcctgga gctggcttcc atgatccccg ccctgcggga gctgggcagt
        70         80         90        100        110        120
gccacaccag aggaatataa tacagttgta cagaagccaa gacaaattct gtgtcaattc
       130        140        150        160        170        180
attgaccgga tacttacaga tgtaaatgtt gttgctgtag aacttgtaaa gaaaactgac
       190        200        210        220        230        240
tctcagccaa cctccgtgat gttgcttgat ttcatccagc atatcatgaa atcctcccca
       250        260        270        280        290        300
cttatgtttg taaatgtgag tggaagccat gaggccaaag gcagttgtat tgaattcagt
       310        320        330        340        350        360
aattggatca taacgagact tctgcggatt gcagcaactc cctcctgtca tttgttacac
       370        380        390        400        410        420
aagaaaatct gtgaagtcat ctgttcatta ttatttcttt ttaaaagcaa gagtcctgct
       430        440        450        460        470        480
atttttgggg tactcacaaa agaattatta caactttttg aagacttggt ttacctccat
       490        500        510        520        530        540
agaagaaatg tgatgggtca tgctgtggaa tggccagtgg tcatgagccg atttttaagt
       550        560        570        580        590        600
caattagatg aacacatggg atatttacaa tcagctcctt tgcagttgat gagtatgcaa
       610        620        630        640        650        660
aatttagaat ttattgaagt cactttatta atggttctta ctcgtattat tgcaattgtg
       670        680        690        700        710        720
ttttttagaa ggcaagaact cttactttgg cagataggtt gtgttctgct agagtatggt
       730        740        750        760        770        780
agtccaaaaa ttaaatccct agcaattagc tttttaacag aactttttca gcttggagga
       790        800        810        820        830        840
ctaccagcac aaccagctag cacttttttc agctcatttt tggaattatt aaaacacctt
       850        860        870        880        890        900
gtagaaatgg atactgacca attgaaactc tatgaagagc cattatcaaa gctgataaag
       910        920        930        940        950        960
acactatttc cctttgaagc agaagcttat agaaatattg aacctgtcta tttaaatatg
       970        980        990       1000       1010       1020
ctgctggaaa aactctgtgt catgtttgaa gacggtgtgc tcatgcggct taagtctgat
      1030       1040       1050       1060       1070       1080
ttgctaaaag cagctttgtg ccatttactg cagtatttcc ttaaatttgt gccagctggg
      1090       1100       1110       1120       1130       1140
tatgaatctg ctttacaagt caggaaggtc tatgtgagaa atatttgtaa agctcttttg
      1150       1160       1170       1180       1190       1200
gatgtgcttg gaattgaggt agatgcagag tacttgttgg gcccacttta tgcagctttg
      1210       1220       1230       1240       1250       1260
aaaatggaaa gtatggaaat cattgaggag attcaatgcc aaactcaaca ggaaaacctc
      1270       1280       1290       1300       1310       1320
agcagtaata gtgatggaat atcacccaaa aggcgtcgtc tcagctcgtc tctaaaccct
      1330       1340       1350       1360       1370       1380
tctaaaagag caccaaaaca gactgaggaa attaaacatg tggacatgaa ccaaaagagc
      1390       1400       1410       1420       1430       1440
atattatgga gtgcactgaa acagaaagct gaatcccttc agatttccct tgaatacagt
      1450       1460       1470       1480       1490       1500
ggcctaaaga atcctgttat tgagatgtta gaaggaattg ctgttgtctt acaactgact
      1510       1520       1530       1540       1550       1560
gctctgtgta ctgttcattg ttctcatcaa aacatgaact gccgtacttt caaggactgt
      1570       1580       1590       1600       1610       1620
caacataaat ccaagaagaa accttctgta gtgataactt ggatgtcatt ggatttttac
      1630       1640       1650       1660       1670       1680
acaaaagtgc ttaagagctg tagaagtttg ttagaatctg ttcagaaact ggacctggag
      1690       1700       1710       1720       1730       1740
gcaaccattg ataaggtggt gaaaatttat gatgctttga tttatatgca agtaaacagt
      1750       1760       1770       1780       1790       1800
tcatttgaag atcatatcct ggaagattta tgtggtatgc tctcacttcc atggatttat
      1810       1820       1830       1840       1850       1860
tcccattctg atgatggctg tttaaagttg accacatttg ccgctaatct tctaacatta
      1870       1880       1890       1900       1910       1920
agctgtagga tttcagatag ctattcacca caggcacaat cacgatgtgt gtttcttctg
      1930       1940       1950       1960       1970       1980
actctgtttc caagaagaat attccttgag tggagaacag cagtttacaa ctgggccctg
      1990       2000       2010       2020       2030       2040
cagagctccc atgaagtaat ccgggctagt tgtgttagtg gattttttat cttattgcag
      2050       2060       2070       2080       2090       2100
cagcagaatt cttgtaacag agttcccaag attcttatag ataaagtcaa agatgattct
      2110       2120       2130       2140       2150       2160
gacattgtca agaaagaatt tgcttctata cttggtcaac ttgtctgtac tcttcacggc
      2170       2180       2190       2200       2210       2220
atgttttatc tgacaagttc tttaacagaa cctttctctg aacacggaca tgtggacctc
      2230       2240       2250       2260       2270       2280
ttctgtagga acttgaaagc cacttctcaa catgaatgtt catcttctca actaaaagct
      2290       2300       2310       2320       2330       2340
tctgtctgca agccattcct tttcctactg aaaaaaaaaa tacctagtcc agtaaaactt
      2350       2360       2370       2380       2390       2400
gctttcatag ataatctaca tcatctttgt aagcatcttg attttagaga agatgaaaca
      2410       2420       2430       2440       2450       2460
gatgtaaaag cagttcttgg aactttatta aatttaatgg aagatccaga caaagatgtt
      2470       2480       2490       2500       2510       2520
agagtggctt ttagtggaaa tatcaagcac atattggaat ccttggactc tgaagatgga
      2530       2540       2550       2560       2570       2580
tttataaagg agctttttgt cttaagaatg aaggaagcat atacacatgc ccaaatatca
      2590       2600       2610       2620       2630       2640
agaaataatg agctgaagga taccttgatt cttacaacag gggatattgg aagggccgca
      2650       2660       2670       2680       2690       2700
aaaggagatt tggtaccatt tgcactctta cacttattgc attgtttgtt atccaagtca
      2710       2720       2730       2740       2750       2760
gcatctgtct ctggagcagc atacacagaa attagagctc tggttgcagc taaaagtgtt
      2770       2780       2790       2800       2810       2820
aaactgcaaa gttttttcag ccagtataag aaacccatct gtcagttttt ggtagaatcc
      2830       2840       2850       2860       2870       2880
cttcactcta gtcagatgac agcacttccg aatactccat gccagaatgc tgacgtgcga
      2890       2900       2910       2920       2930       2940
aaacaagatg tggctcacca gagagaaatg gctttaaata cgttgtctga aattgccaac
      2950       2960       2970       2980       2990       3000
gttttcgact ttcctgatct taatcgtttt cttactagga cattacaagt tctactacct
      3010       3020       3030       3040       3050       3060
gatcttgctg ccaaagcaag ccctgcagct tctgctctca ttcgaacttt aggaaaacaa
      3070       3080       3090       3100       3110       3120
ttaaatgtca atcgtagaga gattttaata aacaacttca aatatatttt ttctcatttg
      3130       3140       3150       3160       3170       3180
gtctgttctt gttccaaaga tgaattagaa cgtgcccttc attatctgaa gaatgaaaca
      3190       3200       3210       3220       3230       3240
gaaattgaac tggggagcct gttgagacaa gatttccaag gattgcataa tgaattattg
      3250       3260       3270       3280       3290       3300
ctgcgtattg gagaacacta tcaacaggtt tttaatggtt tgtcaatact tgcctcattt
      3310       3320       3330       3340       3350       3360
gcatccagtg atgatccata tcagggcccg agagatatca tatcacctga actgatggct
      3370       3380       3390       3400       3410       3420
gattatttac aacccaaatt gttgggcatt ttggcttttt ttaacatgca gttactgagc
      3430       3440       3450       3460       3470       3480
tctagtgttg gcattgaaga taagaaaatg gccttgaaca gtttgatgtc tttgatgaag
      3490       3500       3510       3520       3530       3540
ttaatgggac ccaaacatgt cagttctgtg agggtgaaga tgatgaccac actgagaact
      3550       3560       3570       3580       3590       3600
ggccttcgat tcaaggatga ttttcctgaa ttgtgttgca gagcttggga ctgctttgtt
      3610       3620       3630       3640       3650       3660
cgctgcctgg atcatgcttg tctgggctcc cttctcagtc atgtaatagt agctttgtta
      3670       3680       3690       3700       3710       3720
cctcttatac acatccagcc taaagaaact gcagctatct tccactacct cataattgaa
      3730       3740       3750       3760       3770       3780
aacagggatg ctgtgcaaga ttttcttcat gaaatatatt ttttacctga tcatccagaa
      3790       3800       3810       3820       3830       3840
ttaaaaaaga taaaagccgt tctccaggaa tacagaaagg agacctctga gagcactgat
      3850       3860       3870       3880       3890       3900
cttcagacaa ctcttcagct ctctatgaag gccattcaac atgaaaatgt cgatgttcgt
      3910       3920       3930       3940       3950       3960
attcatgctc ttacaagctt gaaggaaacc ttgtataaaa atcaggaaaa actgataaag
      3970       3980       3990       4000       4010       4020
tatgcaacag acagtgaaac agtagaacct attatctcac agttggtgac agtgcttttg
      4030       4040       4050       4060       4070       4080
aaaggttgcc aagatgcaaa ctctcaagct cggttgctct gtggggaatg tttaggggaa
      4090       4100       4110       4120       4130       4140
ttgggggcga tagatccagg tcgattagat ttctcaacaa ctgaaactca aggaaaagat
      4150       4160       4170       4180       4190       4200
tttacatttg tgactggagt agaagattca agctttgcct atggattatt gatggagcta
      4210       4220       4230       4240       4250       4260
acaagagctt accttgcgta tgctgataat agccgagctc aagattcagc tgcctatgcc
      4270       4280       4290       4300       4310       4320
attcaggagt tgctttctat ttatgactgt agagagatgg agaccaacgg cccaggtcac
      4330       4340       4350       4360       4370       4380
caattgtgga ggagatttcc tgagcatgtt cgggaaatac tagaacctca tctaaatacc
      4390       4400       4410       4420       4430       4440
agatacaaga gttctcagaa gtcaaccgat tggtctggag taaagaagcc aatttactta
      4450       4460       4470       4480       4490       4500
agtaaattgg gtagtaactt tgcagaatgg tcagcatctt gggcaggtta tcttattaca
      4510       4520       4530       4540       4550       4560
aaggttcgac atgatcttgc cagtaaaatt ttcacctgct gtagcattat gatgaagcat
      4570       4580       4590       4600       4610       4620
gatttcaaag tgaccatcta tcttcttcca catattctgg tgtatgtctt actgggttgt
      4630       4640       4650       4660       4670       4680
aatcaagaag atcagcagga ggtttatgca gaaattatgg cagttctaaa gcatgacgat
      4690       4700       4710       4720       4730       4740
cagcatacca taaataccca agacattgca tctgatctgt gtcaactcag tacacagact
      4750       4760       4770       4780       4790       4800
gtgttctcca tgcttgacca tctcacacag tgggcaaggc acaaatttca ggcactgaaa
      4810       4820       4830       4840       4850       4860
gctgagaaat gtccacacag caaatcaaac agaaataagg tagactcaat ggtatctact
      4870       4880       4890       4900       4910       4920
gtggattatg aagactatca gagtgtaacc cgttttctag acctcatacc ccaggatact
      4930       4940       4950       4960       4970       4980
ctggcagtag cttcctttcg ctccaaagca tacacacgag ctgtaatgca ctttgaatca
      4990       5000       5010       5020       5030       5040
tttattacag aaaagaagca aaatattcag gaacatcttg gatttttaca gaaattgtat
      5050       5060       5070       5080       5090       5100
gctgctatgc atgaacctga tggagtggcc ggagtcagtg caattagaaa ggcagaacca
      5110       5120       5130       5140       5150       5160
tctctaaaag aacagatcct tgaacatgaa agccttggct tgctgaggga tgccactgct
      5170       5180       5190       5200       5210       5220
tgttatgaca gggctattca gctagaacca gaccagatca ttcattatca tggtgtagta
      5230       5240       5250       5260       5270       5280
aagtccatgt taggtcttgg tcagctgtct actgttatca ctcaggtgaa tggagtgcat
      5290       5300       5310       5320       5330       5340
gctaacaggt ccgagtggac agatgaatta aacacgtaca gagtggaagc agcttggaaa
      5350       5360       5370       5380       5390       5400
ttgtcacagt gggatttggt ggaaaactat ttggcagcag atggaaaatc tacaacatgg
      5410       5420       5430       5440       5450       5460
agtgtcagac tgggacagct attattatca gccaaaaaaa gagatatcac agctttttat
      5470       5480       5490       5500       5510       5520
gactcactga aactagtgag agcagaacaa attgtacctc tttcagctgc aagctttgaa
      5530       5540       5550       5560       5570       5580
agaggctcct accaacgagg atatgaatat attgtgagat tgcacatgtt atgtgagttg
      5590       5600       5610       5620       5630       5640
gagcatagca tcaaaccact tttccagcat tctccaggtg acagttctca agaagattct
      5650       5660       5670       5680       5690       5700
ctaaactggg tagctcgact agaaatgacc cagaattcct acagagccaa ggagcctatc
      5710       5720       5730       5740       5750       5760
ctggctctcc ggagggcttt actaagcctc aacaaaagac cagattacaa tgaaatggtt
      5770       5780       5790       5800       5810       5820
ggagaatgct ggctgcagag tgccagggta gctagaaagg ctggtcacca ccagacagcc
      5830       5840       5850       5860       5870       5880
tacaatgctc tccttaatgc aggggaatca cgactcgctg aactgtacgt ggaaagggca
      5890       5900       5910       5920       5930       5940
aagtggctct ggtccaaggg tgatgttcac caggcactaa ttgttcttca aaaaggtgtt
      5950       5960       5970       5980       5990       6000
gaattatgtt ttcctgaaaa tgaaacccca cctgagggta agaacatgtt aatccatggt
      6010       6020       6030       6040       6050       6060
cgagctatgc tactagtggg ccgatttatg gaagaaacag ctaactttga aagcaatgca
      6070       6080       6090       6100       6110       6120
attatgaaaa aatataagga tgtgaccgcg tgcctgccag aatgggagga tgggcatttt
      6130       6140       6150       6160       6170       6180
taccttgcca agtactatga caaattgatg cccatggtca cagacaacaa aatggaaaag
      6190       6200       6210       6220       6230       6240
caaggtgatc tcatccggta tatagttctt cattttggca gatctctaca atatggaaat
      6250       6260       6270       6280       6290       6300
cagttcatat atcagtcaat gccacgaatg ttaactctat ggcttgatta tggtacaaag
      6310       6320       6330       6340       6350       6360
gcatatgaat gggaaaaagc tggccgctcc gatcgtgtac aaatgaggaa tgatttgggt
      6370       6380       6390       6400       6410       6420
aaaataaaca aggttatcac agagcataca aactatttag ctccatatca atttttgact
      6430       6440       6450       6460       6470       6480
gctttttcac aattgatctc tcgaatttgt cattctcacg atgaagtttt tgttgtcttg
      6490       6500       6510       6520       6530       6540
atggaaataa tagccaaagt atttctagcc tatcctcaac aagcaatgtg gatgatgaca
      6550       6560       6570       6580       6590       6600
gctgtgtcaa agtcatctta tcccatgcgt gtgaacagat gcaaggaaat cctcaataaa
      6610       6620       6630       6640       6650       6660
gctattcata tgaaaaaatc cttagagaag tttgttggag atgcaactcg cctaacagat
      6670       6680       6690       6700       6710       6720
aagcttctag aattgtgcaa taaaccggtt gatggaagta gttccacatt aagcatgagc
      6730       6740       6750       6760       6770       6780
actcatttta aaatgcttaa aaagctggta gaagaagcaa catttagtga aatcctcatt
      6790       6800       6810       6820       6830       6840
cctctacaat cagtcatgat acctacactt ccatcaattc tgggtaccca tgctaaccat
      6850       6860       6870       6880       6890       6900
gctagccatg aaccatttcc tggacattgg gcctatattg cagggtttga tgatatggtg
      6910       6920       6930       6940       6950       6960
gaaattcttg cttctcttca gaaaccaaag aagatttctt taaaaggctc agatggaaag
      6970       6980       6990       7000       7010       7020
ttctacatca tgatgtgtaa gccaaaagat gacctgagaa aggattgtag actaatggaa
      7030       7040       7050       7060       7070       7080
ttcaattcct tgattaataa gtgcttaaga aaagatgcag agtctcgtag aagagaactt
      7090       7100       7110       7120       7130       7140
catattcgaa catatgcagt tattccacta aatgatgaat gtgggattat tgaatgggtg
      7150       7160       7170       7180       7190       7200
aacaacactg ctggtttgag acctattctg accaaactat ataaagaaaa gggagtgtat
      7210       7220       7230       7240       7250       7260
atgacaggaa aagaacttcg ccagtgtatg ctaccaaagt cagcagcttt atctgaaaaa
      7270       7280       7290       7300       7310       7320
ctcaaagtat tccgagaatt tctcctgccc aggcatcctc ctatttttca tgagtggttt
      7330       7340       7350       7360       7370       7380
ctgagaacat tccctgatcc tacatcatgg tacagtagta gatcagctta ctgccgttcc
      7390       7400       7410       7420       7430       7440
actgcagtaa tgtcaatggt tggttatatt ctggggcttg gagaccgtca tggtgaaaat
      7450       7460       7470       7480       7490       7500
attctctttg attctttgac tggtgaatgc gtacatgtag atttcaattg tcttttcaat
      7510       7520       7530       7540       7550       7560
aagggagaaa cctttgaagt tccagaaatt gtgccatttc gcctgactca taatatggtt
      7570       7580       7590       7600       7610       7620
aatggaatgg gtcctatggg aacagagggt ctttttcgaa gagcatgtga agttacaatg
      7630       7640       7650       7660       7670       7680
aggctgatgc gtgatcagcg agagccttta atgagtgtct taaagacttt tctacatgat
      7690       7700       7710       7720       7730       7740
cctcttgtgg aatggagtaa accagtgaaa gggcattcca aagcgccact gaatgaaact
      7750       7760       7770       7780       7790       7800
ggagaagttg tcaatgaaaa ggccaagacc catgttcttg acattgagca gcgactacaa
      7810       7820       7830       7840       7850       7860
ggtgtaatca agactcgaaa tagagtgaca ggactgccgt tatctattga aggacatgtg
      7870       7880       7890       7900       7910       7920
cattacctta tacaggaagc tactgatgaa aacttactat gccagatgta tcttggttgg
      7930
actccatata tgtga    

Last modification date: Oct. 2, 2011