Homo sapiens L. (human) [HSA]

FULL NAME: Three prime repair exonuclease 2


DESCRIPTION:
Exonuclease with a preference for double stranded DNA with mismatched 3' termini. May play a role in DNA repair.

STRUCTURE SIMILARITY:
Belongs to the exonuclease superfamily. TREX family.


CATALYTIC ACTIVITY:
Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.


PROTEIN TYPE(S):
DNase
3'-5' exonuclease


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway


RELATED DAMAGE:
3'-OH end


Amino acids sequence

        10         20         30         40         50         60
MGRAGSPLPR SSWPRMDDCG SRSRCSPTLC SSLRTCYPRG NITMSEAPRA ETFVFLDLEA
        70         80         90        100        110        120
TGLPSVEPEI AELSLFAVHR SSLENPEHDE SGALVLPRVL DKLTLCMCPE RPFTAKASEI
       130        140        150        160        170        180
TGLSSEGLAR CRKAGFDGAV VRTLQAFLSR QAGPICLVAH NGFDYDFPLL CAELRRLGAR
       190        200        210        220        230        240
LPRDTVCLDT LPALRGLDRA HSHGTRARGR QGYSLGSLFH RYFRAEPSAA HSAEGDVHTL
       250        260        270
LLIFLHRAAE LLAWADEQAR GWAHIEPMYL PPDDPSLEA  

Encoded by TREX2 gene

FULL NAME: three prime repair exonuclease 2


DESCRIPTION:
This gene encodes a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgtccgagg caccccgggc cgagaccttt gtcttcctgg acctggaagc cactgggctc
        70         80         90        100        110        120
cccagtgtgg agcccgagat tgccgagctg tccctctttg ctgtccaccg ctcctccctg
       130        140        150        160        170        180
gagaacccgg agcacgacga gtctggtgcc ctagtattgc cccgggtcct ggacaagctc
       190        200        210        220        230        240
acgctgtgca tgtgcccgga gcgccccttc actgccaagg ccagcgagat caccggcctg
       250        260        270        280        290        300
agcagtgagg gcctggcgcg atgccggaag gctggctttg atggcgccgt ggtgcggacg
       310        320        330        340        350        360
ctgcaggcct tcctgagccg ccaggcaggg cccatctgcc ttgtggccca caatggcttt
       370        380        390        400        410        420
gattatgatt tccccctgct gtgtgccgag ctgcggcgcc tgggtgcccg cctgccccgg
       430        440        450        460        470        480
gacactgtct gcctggacac gctgccggcc ctgcggggcc tggaccgcgc ccacagccac
       490        500        510        520        530        540
ggcacccggg cccggggccg ccagggttac agcctcggca gcctcttcca ccgctacttc
       550        560        570        580        590        600
cgggcagagc caagcgcagc ccactcagcc gagggcgacg tgcacaccct gctcctgatc
       610        620        630        640        650        660
ttcctgcacc gcgccgcaga gctgctcgcc tgggccgatg agcaggcccg tgggtgggcc
       670        680        690        700        710
cacatcgagc ccatgtactt gccgcctgat gaccccagcc tggaggcctg a

Last modification date: Oct. 2, 2011