Homo sapiens L. (human) [HSA]

FULL NAME: Fanconi anemia group M protein


DESCRIPTION:
ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.
FANCM and its relatives, Hef, Mph1 and Fml1, are DNA junction-specific helicases/translocases that target and process perturbed replication forks and intermediates of homologous recombination. They have variously been implicated in promoting the activation of the S-phase checkpoint, recruitment of the Fanconi Anemia Core Complex to sites of DNA damage, crossover avoidance during DNA double-strand break repair by homologous recombination, and the replicative bypass of DNA lesions by template switching.

STRUCTURE SIMILARITY:
Belongs to the DEAD box helicase family. DEAH subfamily.
Contains 1 helicase C-terminal domain.
Contains 1 helicase ATP-binding domain.


SUBUNIT STRUCTURE:
Belongs to the multisubunit FA complex composed of APITD1, FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM, FAAP24 and STRA13/CENPX. The complex is not found in FA patients. Interacts with APITD1/CENPS, FAAP24 and EME1.


CATALYTIC ACTIVITY:
ATP + H(2)O = ADP + phosphate.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated; hyperphosphorylated in response to genotoxic stress.


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway


RELATED DISEASE(S):
Fanconi anemia, complementation group M (FANCM)


Amino acids sequence

        10         20         30         40         50         60
MSGRQRTLFQ TWGSSISRSS GTPGCSSGTE RPQSPGSSKA PLPAAAEAQL ESDDDVLLVA
        70         80         90        100        110        120
AYEAERQLCL ENGGFCTSAG ALWIYPTNCP VRDYQLHISR AALFCNTLVC LPTGLGKTFI
       130        140        150        160        170        180
AAVVMYNFYR WFPSGKVVFM APTKPLVTQQ IEACYQVMGI PQSHMAEMTG STQASTRKEI
       190        200        210        220        230        240
WCSKRVLFLT PQVMVNDLSR GACPAAEIKC LVIDEAHKAL GNYAYCQVVR ELVKYTNHFR
       250        260        270        280        290        300
ILALSATPGS DIKAVQQVIT NLLIGQIELR SEDSPDILTY SHERKVEKLI VPLGEELAAI
       310        320        330        340        350        360
QKTYIQILES FARSLIQRNV LMRRDIPNLT KYQIILARDQ FRKNPSPNIV GIQQGIIEGE
       370        380        390        400        410        420
FAICISLYHG YELLQQMGMR SLYFFLCGIM DGTKGMTRSK NELGRNEDFM KLYNHLECMF
       430        440        450        460        470        480
ARTRSTSANG ISAIQQGDKN KKFVYSHPKL KKLEEVVIEH FKSWNAENTT EKKRDETRVM
       490        500        510        520        530        540
IFSSFRDSVQ EIAEMLSQHQ PIIRVMTFVG HASGKSTKGF TQKEQLEVVK QFRDGGYNTL
       550        560        570        580        590        600
VSTCVGEEGL DIGEVDLIIC FDSQKSPIRL VQRMGRTGRK RQGRIVIILS EGREERIYNQ
       610        620        630        640        650        660
SQSNKRSIYK AISSNRQVLH FYQRSPRMVP DGINPKLHKM FITHGVYEPE KPSRNLQRKS
       670        680        690        700        710        720
SIFSYRDGMR QSSLKKDWFL SEEEFKLWNR LYRLRDSDEI KEITLPQVQF SSLQNEENKP
       730        740        750        760        770        780
AQESTTGIHQ LSLSEWRLWQ DHPLPTHQVD HSDRCRHFIG LMQMIEGMRH EEGECSYELE
       790        800        810        820        830        840
VESYLQMEDV TSTFIAPRNE SNNLASDTFI THKKSSFIKN INQGSSSSVI ESDEECAEIV
       850        860        870        880        890        900
KQTHIKPTKI VSLKKKVSKE IKKDQLKKEN NHGIIDSVDN DRNSTVENIF QEDLPNDKRT
       910        920        930        940        950        960
SDTDEIAATC TINENVIKEP CVLLTECQFT NKSTSSLAGN VLDSGYNSFN DEKSVSSNLF
       970        980        990       1000       1010       1020
LPFEEELYIV RTDDQFYNCH SLTKEVLANV ERFLSYSPPP LSGLSDLEYE IAKGTALENL
      1030       1040       1050       1060       1070       1080
LFLPCAEHLR SDKCTCLLSH SAVNSQQNLE LNSLKCINYP SEKSCLYDIP NDNISDEPSL
      1090       1100       1110       1120       1130       1140
CDCDVHKHNQ NENLVPNNRV QIHRSPAQNL VGENNHDVDN SDLPVLSTDQ DESLLLFEDV
      1150       1160       1170       1180       1190       1200
NTEFDDVSLS PLNSKSESLP VSDKTAISET PLVSQFLISD ELLLDNNSEL QDQITRDANS
      1210       1220       1230       1240       1250       1260
FKSRDQRGVQ EEKVKNHEDI FDCSRDLFSV TFDLGFCSPD SDDEILEHTS DSNRPLDDLY
      1270       1280       1290       1300       1310       1320
GRYLEIKEIS DANYVSNQAL IPRDHSKNFT SGTVIIPSNE DMQNPNYVHL PLSAAKNEEL
      1330       1340       1350       1360       1370       1380
LSPGYSQFSL PVQKKVMSTP LSKSNTLNSF SKIRKEILKT PDSSKEKVNL QRFKEALNST
      1390       1400       1410       1420       1430       1440
FDYSEFSLEK SKSSGPMYLH KSCHSVEDGQ LLTSNESEDD EIFRRKVKRA KGNVLNSPED
      1450       1460       1470       1480       1490       1500
QKNSEVDSPL HAVKKRRFPI NRSELSSSDE SENFPKPCSQ LEDFKVCNGN ARRGIKVPKR
      1510       1520       1530       1540       1550       1560
QSHLKHVARK FLDDEAELSE EDAEYVSSDE NDESENEQDS SLLDFLNDET QLSQAINDSE
      1570       1580       1590       1600       1610       1620
MRAIYMKSLR SPMMNNKYKM IHKTHKNINI FSQIPEQDET YLEDSFCVDE EESCKGQSSE
      1630       1640       1650       1660       1670       1680
EEVCVDFNLI TDDCFANSKK YKTRRAVMLK EMMEQNCAHS KKKLSRIILP DDSSEEENNV
      1690       1700       1710       1720       1730       1740
NDKRESNIAV NPSTVKKNKQ QDHCLNSVPS GSSAQSKVRS TPRVNPLAKQ SKQTSLNLKD
      1750       1760       1770       1780       1790       1800
TISEVSDFKP QNHNEVQSTT PPFTTVDSQK DCRKFPVPQK DGSALEDSST SGASCSKSRP
      1810       1820       1830       1840       1850       1860
HLAGTHTSLR LPQEGKGTCI LVGGHEITSG LEVISSLRAI HGLQVEVCPL NGCDYIVSNR
      1870       1880       1890       1900       1910       1920
MVVERRSQSE MLNSVNKNKF IEQIQHLQSM FERICVIVEK DREKTGDTSR MFRRTKSYDS
      1930       1940       1950       1960       1970       1980
LLTTLIGAGI RILFSSCQEE TADLLKELSL VEQRKNVGIH VPTVVNSNKS EALQFYLSIP
      1990       2000       2010       2020       2030       2040
NISYITALNM CHQFSSVKRM ANSSLQEISM YAQVTHQKAE EIYRYIHYVF DIQMLPNDLN

QDRLKSDI     

Encoded by FANCM gene

FULL NAME: Fanconi anemia, complementation group M


OTHER NAME(S):
FAAP250
KIAA1596
MGC176453


DESCRIPTION:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgagcggac ggcaaagaac gctttttcag acgtggggct caagtatctc ccgatcatct
        70         80         90        100        110        120
gggactccgg gttgcagctc cggaactgag cgacctcaga gccctggcag ctccaaggcg
       130        140        150        160        170        180
cctttgccag cagcagcgga ggctcagctg gagtcggacg atgatgtgtt gcttgtcgcg
       190        200        210        220        230        240
gcgtacgagg ctgagcggca gttgtgtcta gagaatggcg ggttctgcac ctccgcgggc
       250        260        270        280        290        300
gccctgtgga tttaccctac caattgccca gtgcgggact accagctgca catttcccgg
       310        320        330        340        350        360
gctgctctgt tttgcaatac gctggtgtgt ctgcctaccg gactgggaaa gacctttatt
       370        380        390        400        410        420
gccgccgtgg tcatgtacaa tttctaccgc tggttccctt caggaaaggt ggtcttcatg
       430        440        450        460        470        480
gccccaacga aacccttggt gacacagcag atcgaggctt gctaccaggt gatgggtatc
       490        500        510        520        530        540
ccgcaatccc acatggccga aatgacaggg tctacacaag cttccaccag gaaggaaata
       550        560        570        580        590        600
tggtgcagta agagagtgct ttttcttaca cctcaggtca tggtaaatga cctttctaga
       610        620        630        640        650        660
ggagcttgtc ccgctgctga aataaagtgt ttagttattg atgaagctca taaagctctc
       670        680        690        700        710        720
ggaaactatg cttattgcca ggttgtaaga gaactagtca aatatacaaa tcactttaga
       730        740        750        760        770        780
atcttggctc taagtgccac accaggtagt gatataaagg ctgtgcaaca agttattact
       790        800        810        820        830        840
aacctgctaa ttgggcagat agagcttcgt tctgaagatt ctccagatat tttgacatat
       850        860        870        880        890        900
tctcatgaaa gaaaagttga aaagcttatt gttccgcttg gtgaagaact tgcagccatc
       910        920        930        940        950        960
caaaagacct atatccagat tttggaatca tttgctcgtt ctttgattca gaggaatgtt
       970        980        990       1000       1010       1020
ttgatgagaa gggatatccc aaatctaaca aaatatcaga taattctggc aagagatcag
      1030       1040       1050       1060       1070       1080
tttaggaaaa acccatctcc gaatattgtg ggaatacaac aaggcataat cgagggagag
      1090       1100       1110       1120       1130       1140
tttgctattt gtattagttt atatcatggt tatgaattat tgcagcaaat gggaatgaga
      1150       1160       1170       1180       1190       1200
tcattatatt tcttcctttg tggaattatg gatggaacta aagggatgac acggtcaaaa
      1210       1220       1230       1240       1250       1260
aatgaacttg gccgaaatga agacttcatg aaactctata atcatctaga gtgtatgttt
      1270       1280       1290       1300       1310       1320
gcacgtacac gtagtacttc agcaaatggt atttctgcta tccaacaagg agataaaaat
      1330       1340       1350       1360       1370       1380
aaaaaatttg tttatagtca tccaaagtta aagaaattag aagaagttgt aattgaacac
      1390       1400       1410       1420       1430       1440
ttcaagtcat ggaatgctga aaacactact gaaaagaaac gtgatgagac ccgagttatg
      1450       1460       1470       1480       1490       1500
atcttctctt catttcgaga tagtgttcaa gaaattgcag aaatgctttc acagcatcag
      1510       1520       1530       1540       1550       1560
ccaattatta gagtaatgac ttttgtcggc catgcctcag ggaaaagcac gaagggtttt
      1570       1580       1590       1600       1610       1620
acccagaagg agcaactgga ggtagtgaaa cagtttcgtg acggtggtta caacacgctg
      1630       1640       1650       1660       1670       1680
gtttctacct gtgtgggtga agaaggtttg gatataggag aagttgatct tataatatgt
      1690       1700       1710       1720       1730       1740
tttgattccc agaagagccc aattcgtctt gtacaacgaa tgggtagaac tggccgtaaa
      1750       1760       1770       1780       1790       1800
cgtcaaggca ggatagttat tatcctttct gaaggacgag aggaacgtat ttataatcag
      1810       1820       1830       1840       1850       1860
agtcagtcca acaaaagaag tatatataaa gctatttcaa gtaacaggca ggtccttcat
      1870       1880       1890       1900       1910       1920
ttttaccaaa gaagtccacg aatggttcct gatggaatca acccaaaatt acacaaaatg
      1930       1940       1950       1960       1970       1980
ttcatcacac atggtgtcta tgaaccagag aagccttctc ggaacttgca gcgaaagtca
      1990       2000       2010       2020       2030       2040
tctatctttt cctataggga tggaatgagg caaagtagcc taaagaaaga ttggttctta
      2050       2060       2070       2080       2090       2100
tcagaagaag aatttaaatt atggaacaga ctttatagat taagggacag tgatgaaatt
      2110       2120       2130       2140       2150       2160
aaagagataa cattgcctca agttcagttt tcttctttac aaaatgagga aaacaaacca
      2170       2180       2190       2200       2210       2220
gctcaagaat caaccactgg aattcatcaa ctctctctct ctgaatggag actgtggcaa
      2230       2240       2250       2260       2270       2280
gatcatcctt tgcctacaca tcaagttgat cactcagatc gatgccgcca ttttataggc
      2290       2300       2310       2320       2330       2340
cttatgcaaa tgatagaggg aatgagacac gaagagggag aatgcagcta tgaattggaa
      2350       2360       2370       2380       2390       2400
gttgaatctt atttacaaat ggaagatgtt acctcaacat ttattgctcc caggaatgaa
      2410       2420       2430       2440       2450       2460
tctaataatc ttgccagtga cacctttatc actcacaaga aatcgtcatt tataaagaac
      2470       2480       2490       2500       2510       2520
ataaatcaag gcagttcatc ctcagtgata gaatctgatg aagaatgtgc tgaaattgtt
      2530       2540       2550       2560       2570       2580
aaacaaactc atatcaaacc tactaaaatt gtttctttaa agaaaaaagt gtctaaagaa
      2590       2600       2610       2620       2630       2640
ataaaaaaag atcagcttaa aaaagaaaat aatcacggta ttatagattc tgtagataat
      2650       2660       2670       2680       2690       2700
gacagaaatt ccactgttga aaatattttt caagaagacc taccaaatga taaaaggaca
      2710       2720       2730       2740       2750       2760
tcagatacag atgaaattgc tgccacatgt actattaatg aaaatgttat taaagaaccg
      2770       2780       2790       2800       2810       2820
tgtgtgttat taacagagtg tcagtttaca aataaatcca ctagttcact tgctggaaat
      2830       2840       2850       2860       2870       2880
gttttagatt ctggttataa cagtttcaat gatgaaaaat ctgtttcatc taacttattt
      2890       2900       2910       2920       2930       2940
cttccattcg aagaagagct ttatattgtt agaacagatg accaatttta taattgtcac
      2950       2960       2970       2980       2990       3000
tcattgacaa aagaggtact agctaatgta gagagatttt tatcttattc tcctccgcct
      3010       3020       3030       3040       3050       3060
ctcagtggac tctcagactt ggaatatgaa attgctaagg gtactgcact tgagaatttg
      3070       3080       3090       3100       3110       3120
cttttcttac cctgtgcaga gcatttacga agtgataaat gcacctgttt gctgtcacat
      3130       3140       3150       3160       3170       3180
tcagctgtga attctcaaca gaatttagaa ttgaattcac ttaaatgtat aaattatcca
      3190       3200       3210       3220       3230       3240
tctgaaaaaa gttgccttta tgatatacct aatgataata tttctgatga gccaagtctc
      3250       3260       3270       3280       3290       3300
tgtgactgtg atgtacataa acataatcaa aatgaaaatt tagtacctaa caatcgtgtt
      3310       3320       3330       3340       3350       3360
caaatacaca gaagccctgc acagaattta gttggagaga acaatcatga tgttgataac
      3370       3380       3390       3400       3410       3420
agtgacctcc cagtattgtc cactgatcaa gatgaaagtt tgctgttatt tgaagatgtt
      3430       3440       3450       3460       3470       3480
aatacagagt tcgacgatgt gagtctttca cccttgaaca gtaaaagcga atctttacct
      3490       3500       3510       3520       3530       3540
gtgtcagaca aaactgctat tagtgaaacg cctctggtct ctcagttctt aatttctgat
      3550       3560       3570       3580       3590       3600
gaacttttgt tggacaataa ttctgaactc caagatcaaa tcacccgtga tgctaatagt
      3610       3620       3630       3640       3650       3660
tttaaatctc gtgatcagag aggtgtacag gaagaaaaag tgaagaatca tgaggatatt
      3670       3680       3690       3700       3710       3720
tttgattgct ctagggattt attttctgtt acctttgatt taggattctg tagtccagat
      3730       3740       3750       3760       3770       3780
tctgatgatg aaatattgga acatacatca gatagcaata gacctctaga tgatctatat
      3790       3800       3810       3820       3830       3840
ggaaggtatt tggaaattaa ggagataagt gatgcaaatt atgtttcgaa tcaagcacta
      3850       3860       3870       3880       3890       3900
ataccaagag atcatagtaa aaattttact agtggaactg ttattatccc atcaaatgaa
      3910       3920       3930       3940       3950       3960
gatatgcaga atccaaatta tgtacatttg ccactgagtg cagcaaaaaa tgaagaattg
      3970       3980       3990       4000       4010       4020
ttatctcctg gttattctca gttttcttta ccagtgcaaa aaaaagttat gagtacacca
      4030       4040       4050       4060       4070       4080
ctctctaaat caaacacatt gaactcattt tctaagataa gaaaggaaat acttaagaca
      4090       4100       4110       4120       4130       4140
ccagattcta gtaaggaaaa agtaaaccta caaagattca aagaagcatt gaattcaact
      4150       4160       4170       4180       4190       4200
tttgattatt cagaattttc tctagaaaag tctaaaagca gtggtccaat gtatctgcat
      4210       4220       4230       4240       4250       4260
aaatcctgtc attctgttga agatggacaa ttattaacaa gtaacgaaag tgaagatgac
      4270       4280       4290       4300       4310       4320
gagattttcc gaagaaaagt taaaagagca aaaggaaatg ttttaaactc tcctgaggat
      4330       4340       4350       4360       4370       4380
cagaaaaata gtgaagttga ttctccactt catgctgtca aaaagcgcag atttcctata
      4390       4400       4410       4420       4430       4440
aacagatcag aattatcatc tagtgatgag agtgagaatt ttcccaaacc atgttcacaa
      4450       4460       4470       4480       4490       4500
ttagaagact tcaaggtttg taacgggaat gccagaagag gcatcaaagt cccaaagaga
      4510       4520       4530       4540       4550       4560
cagagtcact taaagcatgt agctaggaag tttttagatg atgaagcaga actttctgaa
      4570       4580       4590       4600       4610       4620
gaagatgcag aatatgtttc atcagatgaa aatgatgagt cagaaaatga acaagattcc
      4630       4640       4650       4660       4670       4680
tcattacttg actttttaaa tgatgaaact caactttcac aggctataaa tgattctgaa
      4690       4700       4710       4720       4730       4740
atgagagcta tttacatgaa atctttgcgt agtccaatga tgaacaataa gtacaaaatg
      4750       4760       4770       4780       4790       4800
attcataaga cacataaaaa cataaacatt ttctcgcaga ttcctgaaca agatgaaacc
      4810       4820       4830       4840       4850       4860
tatttagagg atagtttttg tgttgatgaa gaggagtctt gcaaaggcca atcaagtgaa
      4870       4880       4890       4900       4910       4920
gaagaagttt gtgttgattt taacttaata actgatgatt gctttgcaaa tagtaaaaag
      4930       4940       4950       4960       4970       4980
tataaaactc gacgtgcagt aatgctaaaa gaaatgatgg aacaaaattg tgcacattca
      4990       5000       5010       5020       5030       5040
aaaaagaaat tatccagaat tattttacca gatgattcaa gtgaggagga gaacaatgta
      5050       5060       5070       5080       5090       5100
aatgataaaa gagaatctaa tattgcggtt aacccaagca ctgttaagaa gaacaaacaa
      5110       5120       5130       5140       5150       5160
caggaccatt gtttaaattc agtgccttct ggatcttctg cgcagtccaa ggtgcgttct
      5170       5180       5190       5200       5210       5220
actccaagag ttaatccatt agcaaagcag agcaaacaga catcgctgaa tttaaaggat
      5230       5240       5250       5260       5270       5280
acaatttccg aagtctcaga cttcaaacct cagaatcata atgaagtcca gtctaccaca
      5290       5300       5310       5320       5330       5340
ccacccttca ctactgttga ttcacagaaa gactgtagaa aatttccagt tccacagaag
      5350       5360       5370       5380       5390       5400
gatggtagtg ctttggagga ttctagcact tcaggggcat cctgttccaa gtcaagacca
      5410       5420       5430       5440       5450       5460
catttagctg ggacacatac ttctcttaga cttccgcagg aaggaaaagg aacctgtatt
      5470       5480       5490       5500       5510       5520
cttgtaggtg gtcatgaaat cacttctgga ttagaagtaa tttcttccct aagagcaatt
      5530       5540       5550       5560       5570       5580
catgggttgc aagtagaagt ttgtcctctt aatggctgtg attacatcgt gagtaatcgc
      5590       5600       5610       5620       5630       5640
atggtggtgg aaaggaggtc tcaatctgag atgttaaata gtgtcaataa gaacaagttc
      5650       5660       5670       5680       5690       5700
attgagcaga tccagcacct gcagagtatg tttgaaagaa tatgtgtgat tgtggaaaag
      5710       5720       5730       5740       5750       5760
gacagagaaa aaacaggaga cacatcaagg atgtttagga gaacaaagag ctatgacagc
      5770       5780       5790       5800       5810       5820
ctgctgacta ccttaattgg cgctggaatc cgaattcttt tcagttcctg ccaagaagaa
      5830       5840       5850       5860       5870       5880
accgcagatt tgctaaagga actgtcttta gtggaacaaa gaaagaatgt tggtattcat
      5890       5900       5910       5920       5930       5940
gttccaacag tggtgaatag taataaaagt gaggcactcc agttttattt aagtattccc
      5950       5960       5970       5980       5990       6000
aatataagtt atataactgc attaaatatg tgtcaccagt tttcatctgt gaaaaggatg
      6010       6020       6030       6040       6050       6060
gctaacagct cacttcaaga aatctccatg tatgcacaag taactcatca gaaggctgag
      6070       6080       6090       6100       6110       6120
gagatctata gatatattca ctatgtattt gacatacaaa tgttaccaaa tgatcttaac
      6130       6140
caagatagac tgaaatctga tatataa   

Last modification date: Dec. 30, 2011