Homo sapiens L. (human) [HSA]

FULL NAME: Fanconi anemia group G protein


DESCRIPTION:
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.

STRUCTURE SIMILARITY:
Contains 4 TPR repeats.


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway


RELATED DISEASE(S):
Fanconi anemia, complementation group G (FANCG)


Amino acids sequence

        10         20         30         40         50         60
MSRQTTSVGS SCLDLWREKN DRLVRQAKVA QNSGLTLRRQ QLAQDALEGL RGLLHSLQGL
        70         80         90        100        110        120
PAAVPVLPLE LTVTCNFIIL RASLAQGFTE DQAQDIQRSL ERVLETQEQQ GPRLEQGLRE
       130        140        150        160        170        180
LWDSVLRASC LLPELLSALH RLVGLQAALW LSADRLGDLA LLLETLNGSQ SGASKDLLLL
       190        200        210        220        230        240
LKTWSPPAEE LDAPLTLQDA QGLKDVLLTA FAYRQGLQEL ITGNPDKALS SLHEAASGLC
       250        260        270        280        290        300
PRPVLVQVYT ALGSCHRKMG NPQRALLYLV AALKEGSAWG PPLLEASRLY QQLGDTTAEL
       310        320        330        340        350        360
ESLELLVEAL NVPCSSKAPQ FLIEVELLLP PPDLASPLHC GTQSQTKHIL ASRCLQTGRA
       370        380        390        400        410        420
GDAAEHYLDL LALLLDSSEP RFSPPPSPPG PCMPEVFLEA AVALIQAGRA QDALTLCEEL
       430        440        450        460        470        480
LSRTSSLLPK MSRLWEDARK GTKELPYCPL WVSATHLLQG QAWVQLGAQK VAISEFSRCL
       490        500        510        520        530        540
ELLFRATPEE KEQGAAFNCE QGCKSDAALQ QLRAAALISR GLEWVASGQD TKALQDFLLS
       550        560        570        580        590        600
VQMCPGNRDT YFHLLQTLKR LDRRDEATAL WWRLEAQTKG SHEDALWSLP LYLESYLSWI
       610        620
RPSDRDAFLE EFRTSLPKSC DL   

Encoded by FANCG gene

FULL NAME: Fanconi anemia, complementation group G


OTHER NAME(S):
FAG
XRCC9


DESCRIPTION:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgtcccgcc agaccacctc tgtgggctcc agctgcctgg acctgtggag ggaaaagaat
        70         80         90        100        110        120
gaccggctcg ttcgacaggc caaggtggct cagaactccg gtctgactct gaggcgacag
       130        140        150        160        170        180
cagttggctc aggatgcact ggaagggctc agagggctcc tccatagtct gcaagggctc
       190        200        210        220        230        240
cctgcagctg ttcctgttct tcccttggag ctgactgtca cctgcaactt cattatcctg
       250        260        270        280        290        300
agggcaagct tggcccaggg tttcacagag gatcaggccc aggatatcca gcggagccta
       310        320        330        340        350        360
gagagagtgc tggagacaca ggagcagcag gggcccaggt tggaacaggg gctcagggag
       370        380        390        400        410        420
ctgtgggact ctgtccttcg tgcttcctgc cttctgccgg agctgctgtc tgccctgcac
       430        440        450        460        470        480
cgcctggttg gcctgcaggc tgccctctgg ttgagtgctg accgtcttgg ggacctggcc
       490        500        510        520        530        540
ttgttactag agaccctgaa tggcagccag agtggagcct ctaaggatct gctgttactt
       550        560        570        580        590        600
ctgaaaactt ggagtccccc agctgaggaa ttagatgctc cattgaccct gcaggatgcc
       610        620        630        640        650        660
cagggattga aggatgtcct cctgacagca tttgcctacc gccaaggtct ccaggagctg
       670        680        690        700        710        720
atcacaggga acccagacaa ggcactaagc agccttcatg aagcggcctc aggcctgtgt
       730        740        750        760        770        780
ccacggcctg tgttggtcca ggtgtacaca gcactggggt cctgtcaccg taagatggga
       790        800        810        820        830        840
aatccacaga gagcactgtt gtacttggtt gcagccctga aagagggatc agcctggggt
       850        860        870        880        890        900
cctccacttc tggaggcctc taggctctat cagcaactgg gggacacaac agcagagctg
       910        920        930        940        950        960
gagagtctgg agctgctagt tgaggccttg aatgtcccat gcagttccaa agccccgcag
       970        980        990       1000       1010       1020
tttctcattg aggtagaatt actactgcca ccacctgacc tagcctcacc ccttcattgt
      1030       1040       1050       1060       1070       1080
ggcactcaga gccagaccaa gcacatacta gcaagcaggt gcctacagac ggggagggca
      1090       1100       1110       1120       1130       1140
ggagacgctg cagagcatta cttggacctg ctggccctgt tgctggatag ctcggagcca
      1150       1160       1170       1180       1190       1200
aggttctccc cacccccctc ccctccaggg ccctgtatgc ctgaggtgtt tttggaggca
      1210       1220       1230       1240       1250       1260
gcggtagcac tgatccaggc aggcagagcc caagatgcct tgactctatg tgaggagttg
      1270       1280       1290       1300       1310       1320
ctcagccgca catcatctct gctacccaag atgtcccggc tgtgggaaga tgccagaaaa
      1330       1340       1350       1360       1370       1380
ggaaccaagg aactgccata ctgcccactc tgggtctctg ccacccacct gcttcagggc
      1390       1400       1410       1420       1430       1440
caggcctggg ttcaactggg tgcccaaaaa gtggcaatta gtgaatttag caggtgcctc
      1450       1460       1470       1480       1490       1500
gagctgctct tccgggccac acctgaggaa aaagaacaag gggcagcttt caactgtgag
      1510       1520       1530       1540       1550       1560
cagggatgta agtcagatgc ggcactgcag cagcttcggg cagccgccct aattagtcgt
      1570       1580       1590       1600       1610       1620
ggactggaat gggtagccag cggccaggat accaaagcct tacaggactt cctcctcagt
      1630       1640       1650       1660       1670       1680
gtgcagatgt gcccaggtaa tcgagacact tactttcacc tgcttcagac tctgaagagg
      1690       1700       1710       1720       1730       1740
ctagatcgga gggatgaggc cactgcactc tggtggaggc tggaggccca aactaagggg
      1750       1760       1770       1780       1790       1800
tcacatgaag atgctctgtg gtctctcccc ctgtacctag aaagctattt gagctggatc
      1810       1820       1830       1840       1850       1860
cgtccctctg atcgtgacgc cttccttgaa gaatttcgga catctctgcc aaagtcttgt

gacctgtag     

Last modification date: Oct. 2, 2011