Homo sapiens L. (human) [HSA]

FULL NAME: Fanconi anemia group F protein


DESCRIPTION:
DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability (By similarity).

RELATED PATHWAY(S):
Fanconi anemia (FA) pathway


RELATED DISEASE(S):
Fanconi anemia, complementation group F (FANCF)


Amino acids sequence

        10         20         30         40         50         60
MESLLQHLDR FSELLAVSST TYVSTWDPAT VRRALQWARY LRHIHRRFGR HGPIRTALER
        70         80         90        100        110        120
RLHNQWRQEG GFGRGPVPGL ANFQALGHCD VLLSLRLLEN RALGDAARYH LVQQLFPGPG
       130        140        150        160        170        180
VRDADEETLQ ESLARLARRR SAVHMLRFNG YRENPNLQED SLMKTQAELL LERLQEVGKA
       190        200        210        220        230        240
EAERPARFLS SLWERLPQNN FLKVIAVALL QPPLSRRPQE ELEPGIHKSP GEGSQVLVHW
       250        260        270        280        290        300
LLGNSEVFAA FCRALPAGLL TLVTSRHPAL SPVYLGLLTD WGQRLHYDLQ KGIWVGTESQ
       310        320        330        340        350        360
DVPWEELHNR FQSLCQAPPP LKDKVLTALE TCKAQDGDFE VPGLSIWTDL LLALRSGAFR
       370
KRQVLGLSAG LSSV    

Encoded by FANCF gene

FULL NAME: Fanconi anemia, complementation group F


OTHER NAME(S):
FAF
MGC126856


DESCRIPTION:
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group F. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atggaatccc ttctgcagca cctggatcgc ttttccgagc ttctggcggt ctcaagcact
        70         80         90        100        110        120
acctacgtca gcacctggga ccccgccacc gtgcgccggg ccttgcagtg ggcgcgctac
       130        140        150        160        170        180
ctgcgccaca tccatcggcg ctttggtcgg catggcccca ttcgcacggc tctggagcgg
       190        200        210        220        230        240
cggctgcaca accagtggag gcaagagggc ggctttgggc ggggtccagt tccgggatta
       250        260        270        280        290        300
gcgaacttcc aggccctcgg tcactgtgac gtcctgctct ctctgcgcct gctggagaac
       310        320        330        340        350        360
cgggccctcg gggatgcagc tcgttaccac ctggtgcagc aactctttcc cggcccgggc
       370        380        390        400        410        420
gtccgggacg ccgatgagga gacactccaa gagagcctgg cccgccttgc ccgccggcgg
       430        440        450        460        470        480
tctgcggtgc acatgctgcg cttcaatggc tatagagaga acccaaatct ccaggaggac
       490        500        510        520        530        540
tctctgatga agacccaggc ggagctgctg ctggagcgtc tgcaggaggt ggggaaggcc
       550        560        570        580        590        600
gaagcggagc gtcccgccag gtttctcagc agcctgtggg agcgcttgcc tcagaacaac
       610        620        630        640        650        660
ttcctgaagg tgatagcggt ggcgctgttg cagccgcctt tgtctcgtcg gccccaagaa
       670        680        690        700        710        720
gagttggaac ccggcatcca caaatcacct ggagagggga gccaagtgct agtccactgg
       730        740        750        760        770        780
cttctgggga attcggaagt ctttgctgcc ttttgtcgcg ccctcccagc cgggcttttg
       790        800        810        820        830        840
actttagtga ctagccgcca cccagcgctg tctcctgtct atctgggtct gctaacagac
       850        860        870        880        890        900
tggggtcaac gtttgcacta tgaccttcag aaaggcattt gggttggaac tgagtcccaa
       910        920        930        940        950        960
gatgtgccct gggaggagtt gcacaatagg tttcaaagcc tctgtcaggc ccctccacct
       970        980        990       1000       1010       1020
ctgaaagata aagttctaac tgccctggag acctgtaaag cgcaggatgg agattttgaa
      1030       1040       1050       1060       1070       1080
gtacctggtc ttagcatctg gacagacctc ttattagctc ttcgtagtgg tgcatttagg
      1090       1100       1110       1120
aaaagacaag ttttgggtct cagcgcaggc ctcagttctg tatag 

Last modification date: Oct. 2, 2011