Homo sapiens L. (human) [HSA]

FULL NAME: Serine-protein kinase ATM


DESCRIPTION:
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends.

STRUCTURE SIMILARITY:
Belongs to the PI3/PI4-kinase family. ATM subfamily.
Contains 1 FATC domain.
Contains 1 PI3K/PI4K domain.
Contains 1 FAT domain.


CATALYTIC ACTIVITY:
ATP + a protein = ADP + a phosphoprotein.


ENZYME REGULATION:
Inhibited by wortmannin.


POST-TRANSLATIONAL MODIFICATION:
Phosphorylated by NUAK1/ARK5. Autophosphorylation on Ser-367, Ser-1893, Ser-1981 correlates with DNA damage-mediated activation of the kinase.
Acetylation, on DNA damage, is required for activation of the kinase activity, dimer-monomer transition, and subsequent autophosphorylation on Ser-1981. Acetylated in vitro by KAT5/TIP60.


PROTEIN TYPE(S):
kinase


RELATED PATHWAY(S):
DNA damage response (DDR)


RELATED DISEASE(S):
ataxia-telangiectasia (AT)
breast cancer (BC)
B-cell non-Hodgkin lymphomas (B-NHL)
B-cell chronic lymphocytic leukemia (B-CLL)
T-cell-prolymphocytic leukemia (T-PLL)
T-cell acute lymphoblastic leukemia (T-ALL)
mantle cell lymphoma


Amino acids sequence

        10         20         30         40         50         60
MSLVLNDLLI CCRQLEHDRA TERKKEVEKF KRLIRDPETI KHLDRHSDSK QGKYLNWDAV
        70         80         90        100        110        120
FRFLQKYIQK ETECLRIAKP NVSASTQASR QKKMQEISSL VKYFIKCANR RAPRLKCQEL
       130        140        150        160        170        180
LNYIMDTVKD SSNGAIYGAD CSNILLKDIL SVRKYWCEIS QQQWLELFSV YFRLYLKPSQ
       190        200        210        220        230        240
DVHRVLVARI IHAVTKGCCS QTDGLNSKFL DFFSKAIQCA RQEKSSSGLN HILAALTIFL
       250        260        270        280        290        300
KTLAVNFRIR VCELGDEILP TLLYIWTQHR LNDSLKEVII ELFQLQIYIH HPKGAKTQEK
       310        320        330        340        350        360
GAYESTKWRS ILYNLYDLLV NEISHIGSRG KYSSGFRNIA VKENLIELMA DICHQVFNED
       370        380        390        400        410        420
TRSLEISQSY TTTQRESSDY SVPCKRKKIE LGWEVIKDHL QKSQNDFDLV PWLQIATQLI
       430        440        450        460        470        480
SKYPASLPNC ELSPLLMILS QLLPQQRHGE RTPYVLRCLT EVALCQDKRS NLESSQKSDL
       490        500        510        520        530        540
LKLWNKIWCI TFRGISSEQI QAENFGLLGA IIQGSLVEVD REFWKLFTGS ACRPSCPAVC
       550        560        570        580        590        600
CLTLALTTSI VPGTVKMGIE QNMCEVNRSF SLKESIMKWL LFYQLEGDLE NSTEVPPILH
       610        620        630        640        650        660
SNFPHLVLEK ILVSLTMKNC KAAMNFFQSV PECEHHQKDK EELSFSEVEE LFLQTTFDKM
       670        680        690        700        710        720
DFLTIVRECG IEKHQSSIGF SVHQNLKESL DRCLLGLSEQ LLNNYSSEIT NSETLVRCSR
       730        740        750        760        770        780
LLVGVLGCYC YMGVIAEEEA YKSELFQKAK SLMQCAGESI TLFKNKTNEE FRIGSLRNMM
       790        800        810        820        830        840
QLCTRCLSNC TKKSPNKIAS GFFLRLLTSK LMNDIADICK SLASFIKKPF DRGEVESMED
       850        860        870        880        890        900
DTNGNLMEVE DQSSMNLFND YPDSSVSDAN EPGESQSTIG AINPLAEEYL SKQDLLFLDM
       910        920        930        940        950        960
LKFLCLCVTT AQTNTVSFRA ADIRRKLLML IDSSTLEPTK SLHLHMYLML LKELPGEEYP
       970        980        990       1000       1010       1020
LPMEDVLELL KPLSNVCSLY RRDQDVCKTI LNHVLHVVKN LGQSNMDSEN TRDAQGQFLT
      1030       1040       1050       1060       1070       1080
VIGAFWHLTK ERKYIFSVRM ALVNCLKTLL EADPYSKWAI LNVMGKDFPV NEVFTQFLAD
      1090       1100       1110       1120       1130       1140
NHHQVRMLAA ESINRLFQDT KGDSSRLLKA LPLKLQQTAF ENAYLKAQEG MREMSHSAEN
      1150       1160       1170       1180       1190       1200
PETLDEIYNR KSVLLTLIAV VLSCSPICEK QALFALCKSV KENGLEPHLV KKVLEKVSET
      1210       1220       1230       1240       1250       1260
FGYRRLEDFM ASHLDYLVLE WLNLQDTEYN LSSFPFILLN YTNIEDFYRS CYKVLIPHLV
      1270       1280       1290       1300       1310       1320
IRSHFDEVKS IANQIQEDWK SLLTDCFPKI LVNILPYFAY EGTRDSGMAQ QRETATKVYD
      1330       1340       1350       1360       1370       1380
MLKSENLLGK QIDHLFISNL PEIVVELLMT LHEPANSSAS QSTDLCDFSG DLDPAPNPPH
      1390       1400       1410       1420       1430       1440
FPSHVIKATF AYISNCHKTK LKSILEILSK SPDSYQKILL AICEQAAETN NVYKKHRILK
      1450       1460       1470       1480       1490       1500
IYHLFVSLLL KDIKSGLGGA WAFVLRDVIY TLIHYINQRP SCIMDVSLRS FSLCCDLLSQ
      1510       1520       1530       1540       1550       1560
VCQTAVTYCK DALENHLHVI VGTLIPLVYE QVEVQKQVLD LLKYLVIDNK DNENLYITIK
      1570       1580       1590       1600       1610       1620
LLDPFPDHVV FKDLRITQQK IKYSRGPFSL LEEINHFLSV SVYDALPLTR LEGLKDLRRQ
      1630       1640       1650       1660       1670       1680
LELHKDQMVD IMRASQDNPQ DGIMVKLVVN LLQLSKMAIN HTGEKEVLEA VGSCLGEVGP
      1690       1700       1710       1720       1730       1740
IDFSTIAIQH SKDASYTKAL KLFEDKELQW TFIMLTYLNN TLVEDCVKVR SAAVTCLKNI
      1750       1760       1770       1780       1790       1800
LATKTGHSFW EIYKMTTDPM LAYLQPFRTS RKKFLEVPRF DKENPFEGLD DINLWIPLSE
      1810       1820       1830       1840       1850       1860
NHDIWIKTLT CAFLDSGGTK CEILQLLKPM CEVKTDFCQT VLPYLIHDIL LQDTNESWRN
      1870       1880       1890       1900       1910       1920
LLSTHVQGFF TSCLRHFSQT SRSTTPANLD SESEHFFRCC LDKKSQRTML AVVDYMRRQK
      1930       1940       1950       1960       1970       1980
RPSSGTIFND AFWLDLNYLE VAKVAQSCAA HFTALLYAEI YADKKSMDDQ EKRSLAFEEG
      1990       2000       2010       2020       2030       2040
SQNTTISSLS EKSKEETGIS LQDLLLEIYR SIGEPDSLYG CGGGKMLQPI TRLRTYEHEA
      2050       2060       2070       2080       2090       2100
MWGKALVTYD LETAIPSSTR QAGIIQALQN LGLCHILSVY LKGLDYENKD WCPELEELHY
      2110       2120       2130       2140       2150       2160
QAAWRNMQWD HCTSVSKEVE GTSYHESLYN ALQSLRDREF STFYESLKYA RVKEVEEMCK
      2170       2180       2190       2200       2210       2220
RSLESVYSLY PTLSRLQAIG ELESIGELFS RSVTHRQLSE VYIKWQKHSQ LLKDSDFSFQ
      2230       2240       2250       2260       2270       2280
EPIMALRTVI LEILMEKEMD NSQRECIKDI LTKHLVELSI LARTFKNTQL PERAIFQIKQ
      2290       2300       2310       2320       2330       2340
YNSVSCGVSE WQLEEAQVFW AKKEQSLALS ILKQMIKKLD ASCAANNPSL KLTYTECLRV
      2350       2360       2370       2380       2390       2400
CGNWLAETCL ENPAVIMQTY LEKAVEVAGN YDGESSDELR NGKMKAFLSL ARFSDTQYQR
      2410       2420       2430       2440       2450       2460
IENYMKSSEF ENKQALLKRA KEEVGLLREH KIQTNRYTVK VQRELELDEL ALRALKEDRK
      2470       2480       2490       2500       2510       2520
RFLCKAVENY INCLLSGEEH DMWVFRLCSL WLENSGVSEV NGMMKRDGMK IPTYKFLPLM
      2530       2540       2550       2560       2570       2580
YQLAARMGTK MMGGLGFHEV LNNLISRISM DHPHHTLFII LALANANRDE FLTKPEVARR
      2590       2600       2610       2620       2630       2640
SRITKNVPKQ SSQLDEDRTE AANRIICTIR SRRPQMVRSV EALCDAYIIL ANLDATQWKT
      2650       2660       2670       2680       2690       2700
QRKGINIPAD QPITKLKNLE DVVVPTMEIK VDHTGEYGNL VTIQSFKAEF RLAGGVNLPK
      2710       2720       2730       2740       2750       2760
IIDCVGSDGK ERRQLVKGRD DLRQDAVMQQ VFQMCNTLLQ RNTETRKRKL TICTYKVVPL
      2770       2780       2790       2800       2810       2820
SQRSGVLEWC TGTVPIGEFL VNNEDGAHKR YRPNDFSAFQ CQKKMMEVQK KSFEEKYEVF
      2830       2840       2850       2860       2870       2880
MDVCQNFQPV FRYFCMEKFL DPAIWFEKRL AYTRSVATSS IVGYILGLGD RHVQNILINE
      2890       2900       2910       2920       2930       2940
QSAELVHIDL GVAFEQGKIL PTPETVPFRL TRDIVDGMGI TGVEGVFRRC CEKTMEVMRN
      2950       2960       2970       2980       2990       3000
SQETLLTIVE VLLYDPLFDW TMNPLKALYL QQRPEDETEL HPTLNADDQE CKRNLSDIDQ
      3010       3020       3030       3040       3050
SFNKVAERVL MRLQEKLKGV EEGTVLSVGG QVNLLIQQAI DPKNLSRLFP GWKAWV

Encoded by ATM gene

FULL NAME: ataxia telangiectasia mutated


OTHER NAME(S):
AT1
ATA
ATC
ATD
ATDC
ATE
DKFZp781A0353
MGC74674
TEL1
TELO1


DESCRIPTION:
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]


Nucleic acid sequence

        10         20         30         40         50         60
atgagtctag tacttaatga tctgcttatc tgctgccgtc aactagaaca tgatagagct
        70         80         90        100        110        120
acagaacgaa agaaagaagt tgagaaattt aagcgcctga ttcgagatcc tgaaacaatt
       130        140        150        160        170        180
aaacatctag atcggcattc agattccaaa caaggaaaat atttgaattg ggatgctgtt
       190        200        210        220        230        240
tttagatttt tacagaaata tattcagaaa gaaacagaat gtctgagaat agcaaaacca
       250        260        270        280        290        300
aatgtatcag cctcaacaca agcctccagg cagaaaaaga tgcaggaaat cagtagtttg
       310        320        330        340        350        360
gtcaaatact tcatcaaatg tgcaaacaga agagcaccta ggctaaaatg tcaagaactc
       370        380        390        400        410        420
ttaaattata tcatggatac agtgaaagat tcatctaatg gtgctattta cggagctgat
       430        440        450        460        470        480
tgtagcaaca tactactcaa agacattctt tctgtgagaa aatactggtg tgaaatatct
       490        500        510        520        530        540
cagcaacagt ggttagaatt gttctctgtg tacttcaggc tctatctgaa accttcacaa
       550        560        570        580        590        600
gatgttcata gagttttagt ggctagaata attcatgctg ttaccaaagg atgctgttct
       610        620        630        640        650        660
cagactgacg gattaaattc caaatttttg gacttttttt ccaaggctat tcagtgtgcg
       670        680        690        700        710        720
agacaagaaa agagctcttc aggtctaaat catatcttag cagctcttac tatcttcctc
       730        740        750        760        770        780
aagactttgg ctgtcaactt tcgaattcga gtgtgtgaat taggagatga aattcttccc
       790        800        810        820        830        840
actttgcttt atatttggac tcaacatagg cttaatgatt ctttaaaaga agtcattatt
       850        860        870        880        890        900
gaattatttc aactgcaaat ttatatccat catccgaaag gagccaaaac ccaagaaaaa
       910        920        930        940        950        960
ggtgcttatg aatcaacaaa atggagaagt attttataca acttatatga tctgctagtg
       970        980        990       1000       1010       1020
aatgagataa gtcatatagg aagtagagga aagtattctt caggatttcg taatattgcc
      1030       1040       1050       1060       1070       1080
gtcaaagaaa atttgattga attgatggca gatatctgtc accaggtttt taatgaagat
      1090       1100       1110       1120       1130       1140
accagatcct tggagatttc tcaatcttac actactacac aaagagaatc tagtgattac
      1150       1160       1170       1180       1190       1200
agtgtccctt gcaaaaggaa gaaaatagaa ctaggctggg aagtaataaa agatcacctt
      1210       1220       1230       1240       1250       1260
cagaagtcac agaatgattt tgatcttgtg ccttggctac agattgcaac ccaattaata
      1270       1280       1290       1300       1310       1320
tcaaagtatc ctgcaagttt acctaactgt gagctgtctc cattactgat gatactatct
      1330       1340       1350       1360       1370       1380
cagcttctac cccaacagcg acatggggaa cgtacaccat atgtgttacg atgccttacg
      1390       1400       1410       1420       1430       1440
gaagttgcat tgtgtcaaga caagaggtca aacctagaaa gctcacaaaa gtcagattta
      1450       1460       1470       1480       1490       1500
ttaaaactct ggaataaaat ttggtgtatt acctttcgtg gtataagttc tgagcaaata
      1510       1520       1530       1540       1550       1560
caagctgaaa actttggctt acttggagcc ataattcagg gtagtttagt tgaggttgac
      1570       1580       1590       1600       1610       1620
agagaattct ggaagttatt tactgggtca gcctgcagac cttcatgtcc tgcagtatgc
      1630       1640       1650       1660       1670       1680
tgtttgactt tggcactgac caccagtata gttccaggaa cggtaaaaat gggaatagag
      1690       1700       1710       1720       1730       1740
caaaatatgt gtgaagtaaa tagaagcttt tctttaaagg aatcaataat gaaatggctc
      1750       1760       1770       1780       1790       1800
ttattctatc agttagaggg tgacttagaa aatagcacag aagtgcctcc aattcttcac
      1810       1820       1830       1840       1850       1860
agtaattttc ctcatcttgt actggagaaa attcttgtga gtctcactat gaaaaactgt
      1870       1880       1890       1900       1910       1920
aaagctgcaa tgaatttttt ccaaagcgtg ccagaatgtg aacaccacca aaaagataaa
      1930       1940       1950       1960       1970       1980
gaagaacttt cattctcaga agtagaagaa ctatttcttc agacaacttt tgacaagatg
      1990       2000       2010       2020       2030       2040
gactttttaa ccattgtgag agaatgtggt atagaaaagc accagtccag tattggcttc
      2050       2060       2070       2080       2090       2100
tctgtccacc agaatctcaa ggaatcactg gatcgctgtc ttctgggatt atcagaacag
      2110       2120       2130       2140       2150       2160
cttctgaata attactcatc tgagattaca aattcagaaa ctcttgtccg gtgttcacgt
      2170       2180       2190       2200       2210       2220
cttttggtgg gtgtccttgg ctgctactgt tacatgggtg taatagctga agaggaagca
      2230       2240       2250       2260       2270       2280
tataagtcag aattattcca gaaagccaag tctctaatgc aatgtgcagg agaaagtatc
      2290       2300       2310       2320       2330       2340
actctgttta aaaataagac aaatgaggaa ttcagaattg gttccttgag aaatatgatg
      2350       2360       2370       2380       2390       2400
cagctatgta cacgttgctt gagcaactgt accaagaaga gtccaaataa gattgcatct
      2410       2420       2430       2440       2450       2460
ggctttttcc tgcgattgtt aacatcaaag ctaatgaatg acattgcaga tatttgtaaa
      2470       2480       2490       2500       2510       2520
agtttagcat ccttcatcaa aaagccattt gaccgtggag aagtagaatc aatggaagat
      2530       2540       2550       2560       2570       2580
gatactaatg gaaatctaat ggaggtggag gatcagtcat ccatgaatct atttaacgat
      2590       2600       2610       2620       2630       2640
taccctgata gtagtgttag tgatgcaaac gaacctggag agagccaaag taccataggt
      2650       2660       2670       2680       2690       2700
gccattaatc ctttagctga agaatatctg tcaaagcaag atctactttt cttagacatg
      2710       2720       2730       2740       2750       2760
ctcaagttct tgtgtttgtg tgtaactact gctcagacca atactgtgtc ctttagggca
      2770       2780       2790       2800       2810       2820
gctgatattc ggaggaaatt gttaatgtta attgattcta gcacgctaga acctaccaaa
      2830       2840       2850       2860       2870       2880
tccctccacc tgcatatgta tctaatgctt ttaaaggagc ttcctggaga agagtacccc
      2890       2900       2910       2920       2930       2940
ttgccaatgg aagatgttct tgaacttctg aaaccactat ccaatgtgtg ttctttgtat
      2950       2960       2970       2980       2990       3000
cgtcgtgacc aagatgtttg taaaactatt ttaaaccatg tccttcatgt agtgaaaaac
      3010       3020       3030       3040       3050       3060
ctaggtcaaa gcaatatgga ctctgagaac acaagggatg ctcaaggaca gtttcttaca
      3070       3080       3090       3100       3110       3120
gtaattggag cattttggca tctaacaaag gagaggaaat atatattctc tgtaagaatg
      3130       3140       3150       3160       3170       3180
gccctagtaa attgccttaa aactttgctt gaggctgatc cttattcaaa atgggccatt
      3190       3200       3210       3220       3230       3240
cttaatgtaa tgggaaaaga ctttcctgta aatgaagtat ttacacaatt tcttgctgac
      3250       3260       3270       3280       3290       3300
aatcatcacc aagttcgcat gttggctgca gagtcaatca atagattgtt ccaggacacg
      3310       3320       3330       3340       3350       3360
aagggagatt cttccaggtt actgaaagca cttcctttga agcttcagca aacagctttt
      3370       3380       3390       3400       3410       3420
gaaaatgcat acttgaaagc tcaggaagga atgagagaaa tgtcccatag tgctgagaac
      3430       3440       3450       3460       3470       3480
cctgaaactt tggatgaaat ttataataga aaatctgttt tactgacgtt gatagctgtg
      3490       3500       3510       3520       3530       3540
gttttatcct gtagccctat ctgcgaaaaa caggctttgt ttgccctgtg taaatctgtg
      3550       3560       3570       3580       3590       3600
aaagagaatg gattagaacc tcaccttgtg aaaaaggttt tagagaaagt ttctgaaact
      3610       3620       3630       3640       3650       3660
tttggatata gacgtttaga agactttatg gcatctcatt tagattatct ggttttggaa
      3670       3680       3690       3700       3710       3720
tggctaaatc ttcaagatac tgaatacaac ttatcttctt ttccttttat tttattaaac
      3730       3740       3750       3760       3770       3780
tacacaaata ttgaggattt ctatagatct tgttataagg ttttgattcc acatctggtg
      3790       3800       3810       3820       3830       3840
attagaagtc attttgatga ggtgaagtcc attgctaatc agattcaaga ggactggaaa
      3850       3860       3870       3880       3890       3900
agtcttctaa cagactgctt tccaaagatt cttgtaaata ttcttcctta ttttgcctat
      3910       3920       3930       3940       3950       3960
gagggtacca gagacagtgg gatggcacag caaagagaga ctgctaccaa ggtctatgat
      3970       3980       3990       4000       4010       4020
atgcttaaaa gtgaaaactt attgggaaaa cagattgatc acttattcat tagtaattta
      4030       4040       4050       4060       4070       4080
ccagagattg tggtggagtt attgatgacg ttacatgagc cagcaaattc tagtgccagt
      4090       4100       4110       4120       4130       4140
cagagcactg acctctgtga cttttcaggg gatttggatc ctgctcctaa tccacctcat
      4150       4160       4170       4180       4190       4200
tttccatcgc atgtgattaa agcaacattt gcctatatca gcaattgtca taaaaccaag
      4210       4220       4230       4240       4250       4260
ttaaaaagca ttttagaaat tctttccaaa agccctgatt cctatcagaa aattcttctt
      4270       4280       4290       4300       4310       4320
gccatatgtg agcaagcagc tgaaacaaat aatgtttata agaagcacag aattcttaaa
      4330       4340       4350       4360       4370       4380
atatatcacc tgtttgttag tttattactg aaagatataa aaagtggctt aggaggagct
      4390       4400       4410       4420       4430       4440
tgggcctttg ttcttcgaga cgttatttat actttgattc actatatcaa ccaaaggcct
      4450       4460       4470       4480       4490       4500
tcttgtatca tggatgtgtc attacgtagc ttctcccttt gttgtgactt attaagtcag
      4510       4520       4530       4540       4550       4560
gtttgccaga cagccgtgac ttactgtaag gatgctctag aaaaccatct tcatgttatt
      4570       4580       4590       4600       4610       4620
gttggtacac ttatacccct tgtgtatgag caggtggagg ttcagaaaca ggtattggac
      4630       4640       4650       4660       4670       4680
ttgttgaaat acttagtgat agataacaag gataatgaaa acctctatat cacgattaag
      4690       4700       4710       4720       4730       4740
cttttagatc cttttcctga ccatgttgtt tttaaggatt tgcgtattac tcagcaaaaa
      4750       4760       4770       4780       4790       4800
atcaaataca gtagaggacc cttttcactc ttggaggaaa ttaaccattt tctctcagta
      4810       4820       4830       4840       4850       4860
agtgtttatg atgcacttcc attgacaaga cttgaaggac taaaggatct tcgaagacaa
      4870       4880       4890       4900       4910       4920
ctggaactac ataaagatca gatggtggac attatgagag cttctcagga taatccgcaa
      4930       4940       4950       4960       4970       4980
gatgggatta tggtgaaact agttgtcaat ttgttgcagt tatccaagat ggcaataaac
      4990       5000       5010       5020       5030       5040
cacactggtg aaaaagaagt tctagaggct gttggaagct gcttgggaga agtgggtcct
      5050       5060       5070       5080       5090       5100
atagatttct ctaccatagc tatacaacat agtaaagatg catcttatac caaggccctt
      5110       5120       5130       5140       5150       5160
aagttatttg aagataaaga acttcagtgg accttcataa tgctgaccta cctgaataac
      5170       5180       5190       5200       5210       5220
acactggtag aagattgtgt caaagttcga tcagcagctg ttacctgttt gaaaaacatt
      5230       5240       5250       5260       5270       5280
ttagccacaa agactggaca tagtttctgg gagatttata agatgacaac agatccaatg
      5290       5300       5310       5320       5330       5340
ctggcctatc tacagccttt tagaacatca agaaaaaagt ttttagaagt acccagattt
      5350       5360       5370       5380       5390       5400
gacaaagaaa acccttttga aggcctggat gatataaatc tgtggattcc tctaagtgaa
      5410       5420       5430       5440       5450       5460
aatcatgaca tttggataaa gacactgact tgtgcttttt tggacagtgg aggcacaaaa
      5470       5480       5490       5500       5510       5520
tgtgaaattc ttcaattatt aaagccaatg tgtgaagtga aaactgactt ttgtcagact
      5530       5540       5550       5560       5570       5580
gtacttccat acttgattca tgatatttta ctccaagata caaatgaatc atggagaaat
      5590       5600       5610       5620       5630       5640
ctgctttcta cacatgttca gggatttttc accagctgtc ttcgacactt ctcgcaaacg
      5650       5660       5670       5680       5690       5700
agccgatcca caacccctgc aaacttggat tcagagtcag agcacttttt ccgatgctgt
      5710       5720       5730       5740       5750       5760
ttggataaaa aatcacaaag aacaatgctt gctgttgtgg actacatgag aagacaaaag
      5770       5780       5790       5800       5810       5820
agaccttctt caggaacaat ttttaatgat gctttctggc tggatttaaa ttatctagaa
      5830       5840       5850       5860       5870       5880
gttgccaagg tagctcagtc ttgtgctgct cactttacag ctttactcta tgcagaaatc
      5890       5900       5910       5920       5930       5940
tatgcagata agaaaagtat ggatgatcaa gagaaaagaa gtcttgcatt tgaagaagga
      5950       5960       5970       5980       5990       6000
agccagagta caactatttc tagcttgagt gaaaaaagta aagaagaaac tggaataagt
      6010       6020       6030       6040       6050       6060
ttacaggatc ttctcttaga aatctacaga agtatagggg agccagatag tttgtatggc
      6070       6080       6090       6100       6110       6120
tgtggtggag ggaagatgtt acaacccatt actagactac gaacatatga acacgaagca
      6130       6140       6150       6160       6170       6180
atgtggggca aagccctagt aacatatgac ctcgaaacag caatcccctc atcaacacgc
      6190       6200       6210       6220       6230       6240
caggcaggaa tcattcaggc cttgcagaat ttgggactct gccatattct ttccgtctat
      6250       6260       6270       6280       6290       6300
ttaaaaggat tggattatga aaataaagac tggtgtcctg aactagaaga acttcattac
      6310       6320       6330       6340       6350       6360
caagcagcat ggaggaatat gcagtgggac cattgcactt ccgtcagcaa agaagtagaa
      6370       6380       6390       6400       6410       6420
ggaaccagtt accatgaatc attgtacaat gctctacaat ctctaagaga cagagaattc
      6430       6440       6450       6460       6470       6480
tctacatttt atgaaagtct caaatatgcc agagtaaaag aagtggaaga gatgtgtaag
      6490       6500       6510       6520       6530       6540
cgcagccttg agtctgtgta ttcgctctat cccacactta gcaggttgca ggccattgga
      6550       6560       6570       6580       6590       6600
gagctggaaa gcattgggga gcttttctca agatcagtca cacatagaca actctctgaa
      6610       6620       6630       6640       6650       6660
gtatatatta agtggcagaa acactcccag cttctcaagg acagtgattt tagttttcag
      6670       6680       6690       6700       6710       6720
gagcctatca tggctctacg cacagtcatt ttggagatcc tgatggaaaa ggaaatggac
      6730       6740       6750       6760       6770       6780
aactcacaaa gagaatgtat taaggacatt ctcaccaaac accttgtaga actctctata
      6790       6800       6810       6820       6830       6840
ctggccagaa ctttcaagaa cactcagctc cctgaaaggg caatatttca aattaaacag
      6850       6860       6870       6880       6890       6900
tacaattcag ttagctgtgg agtctctgag tggcagctgg aagaagcaca agtattctgg
      6910       6920       6930       6940       6950       6960
gcaaaaaagg agcagagtct tgccctgagt attctcaagc aaatgatcaa gaagttggat
      6970       6980       6990       7000       7010       7020
gccagctgtg cagcgaacaa tcccagccta aaacttacat acacagaatg tctgagggtt
      7030       7040       7050       7060       7070       7080
tgtggcaact ggttagcaga aacgtgctta gaaaatcctg cggtcatcat gcagacctat
      7090       7100       7110       7120       7130       7140
ctagaaaagg cagtagaagt tgctggaaat tatgatggag aaagtagtga tgagctaaga
      7150       7160       7170       7180       7190       7200
aatggaaaaa tgaaggcatt tctctcatta gcccggtttt cagatactca ataccaaaga
      7210       7220       7230       7240       7250       7260
attgaaaact acatgaaatc atcggaattt gaaaacaagc aagctctcct gaaaagagcc
      7270       7280       7290       7300       7310       7320
aaagaggaag taggtctcct tagggaacat aaaattcaga caaacagata cacagtaaag
      7330       7340       7350       7360       7370       7380
gttcagcgag agctggagtt ggatgaatta gccctgcgtg cactgaaaga ggatcgtaaa
      7390       7400       7410       7420       7430       7440
cgcttcttat gtaaagcagt tgaaaattat atcaactgct tattaagtgg agaagaacat
      7450       7460       7470       7480       7490       7500
gatatgtggg tattccgact ttgttccctc tggcttgaaa attctggagt ttctgaagtc
      7510       7520       7530       7540       7550       7560
aatggcatga tgaagagaga cggaatgaag attccaacat ataaattttt gcctcttatg
      7570       7580       7590       7600       7610       7620
taccaattgg ctgctagaat ggggaccaag atgatgggag gcctaggatt tcatgaagtc
      7630       7640       7650       7660       7670       7680
ctcaataatc taatctctag aatttcaatg gatcaccccc atcacacttt gtttattata
      7690       7700       7710       7720       7730       7740
ctggccttag caaatgcaaa cagagatgaa tttctgacta aaccagaggt agccagaaga
      7750       7760       7770       7780       7790       7800
agcagaataa ctaaaaatgt gcctaaacaa agctctcagc ttgatgagga tcgaacagag
      7810       7820       7830       7840       7850       7860
gctgcaaata gaataatatg tactatcaga agtaggagac ctcagatggt cagaagtgtt
      7870       7880       7890       7900       7910       7920
gaggcacttt gtgatgctta tattatatta gcaaacttag atgccactca gtggaagact
      7930       7940       7950       7960       7970       7980
cagagaaaag gcataaatat tccagcagac cagccaatta ctaaacttaa gaatttagaa
      7990       8000       8010       8020       8030       8040
gatgttgttg tccctactat ggaaattaag gtggaccaca caggagaata tggaaatctg
      8050       8060       8070       8080       8090       8100
gtgactatac agtcatttaa agcagaattt cgcttagcag gaggtgtaaa tttaccaaaa
      8110       8120       8130       8140       8150       8160
ataatagatt gtgtaggttc cgatggcaag gagaggagac agcttgttaa gggccgtgat
      8170       8180       8190       8200       8210       8220
gacctgagac aagatgctgt catgcaacag gtcttccaga tgtgtaatac attactgcag
      8230       8240       8250       8260       8270       8280
agaaacacgg aaactaggaa gaggaaatta actatctgta cttataaggt ggttcccctc
      8290       8300       8310       8320       8330       8340
tctcagcgaa gtggtgttct tgaatggtgc acaggaactg tccccattgg tgaatttctt
      8350       8360       8370       8380       8390       8400
gttaacaatg aagatggtgc tcataaaaga tacaggccaa atgatttcag tgcctttcag
      8410       8420       8430       8440       8450       8460
tgccaaaaga aaatgatgga ggtgcaaaaa aagtcttttg aagagaaata tgaagtcttc
      8470       8480       8490       8500       8510       8520
atggatgttt gccaaaattt tcaaccagtt ttccgttact tctgcatgga aaaattcttg
      8530       8540       8550       8560       8570       8580
gatccagcta tttggtttga gaagcgattg gcttatacgc gcagtgtagc tacttcttct
      8590       8600       8610       8620       8630       8640
attgttggtt acatacttgg acttggtgat agacatgtac agaatatctt gataaatgag
      8650       8660       8670       8680       8690       8700
cagtcagcag aacttgtaca tatagatcta ggtgttgctt ttgaacaggg caaaatcctt
      8710       8720       8730       8740       8750       8760
cctactcctg agacagttcc ttttagactc accagagata ttgtggatgg catgggcatt
      8770       8780       8790       8800       8810       8820
acgggtgttg aaggtgtctt cagaagatgc tgtgagaaaa ccatggaagt gatgagaaac
      8830       8840       8850       8860       8870       8880
tctcaggaaa ctctgttaac cattgtagag gtccttctat atgatccact ctttgactgg
      8890       8900       8910       8920       8930       8940
accatgaatc ctttgaaagc tttgtattta cagcagaggc cggaagatga aactgagctt
      8950       8960       8970       8980       8990       9000
caccctactc tgaatgcaga tgaccaagaa tgcaaacgaa atctcagtga tattgaccag
      9010       9020       9030       9040       9050       9060
agtttcaaca aagtagctga acgtgtctta atgagactac aagagaaact gaaaggagtg
      9070       9080       9090       9100       9110       9120
gaagaaggca ctgtgctcag tgttggtgga caagtgaatt tgctcataca gcaggccata
      9130       9140       9150       9160       9170
gaccccaaaa atctcagccg acttttccca ggatggaaag cttgggtgtg a

Last modification date: Oct. 2, 2011