Homo sapiens L. (human) [HSA]

FULL NAME: Alpha-ketoglutarate-dependent dioxygenase FTO


DESCRIPTION:
Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.

STRUCTURE SIMILARITY:
Belongs to the fto family.


ENZYME REGULATION:
Activated by ascorbate. Inhibited by N-oxalylglycine, fumarate and succinate (By similarity).


PROTEIN TYPE(S):
dioxygenase


RELATED DISEASE(S):
growth retardation, developmental delay, coarse facies, and early death (GDFD)


RELATED DAMAGE:
N3-methylT (3meT) in ssDNA
N3-methyl T (3meT)
3-methylU in ssDNA
3-methyl-U (3meU) in RNA


Amino acids sequence

        10         20         30         40         50         60
MKRTPTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLI LREASSVSEE
        70         80         90        100        110        120
LHKEVQEAFL TLHKHGCLFR DLVRIQGKDL LTPVSRILIG NPGCTYKYLN TRLFTVPWPV
       130        140        150        160        170        180
KGSNIKHTEA EIAAACETFL KLNDYLQIET IQALEELAAK EKANEDAVPL CMSADFPRVG
       190        200        210        220        230        240
MGSSYNGQDE VDIKSRAAYN VTLLNFMDPQ KMPYLKEEPY FGMGKMAVSW HHDENLVDRS
       250        260        270        280        290        300
AVAVYSYSCE GPEEESEDDS HLEGRDPDIW HVGFKISWDI ETPGLAIPLH QGDCYFMLDD
       310        320        330        340        350        360
LNATHQHCVL AGSQPRFSST HRVAECSTGT LDYILQRCQL ALQNVCDDVD NDDVSLKSFE
       370        380        390        400        410        420
PAVLKQGEEI HNEVEFEWLR QFWFQGNRYR KCTDWWCQPM AQLEALWKKM EGVTNAVLHE
       430        440        450        460        470        480
VKREGLPVEQ RNEILTAILA SLTARQNLRR EWHARCQSRI ARTLPADQKP ECRPYWEKDD
       490        500
ASMPLPFDLT DIVSELRGQL LEAKP   

Encoded by FTO gene

FULL NAME: fat mass and obesity associated


OTHER NAME(S):
MGC5149
KIAA1752


DESCRIPTION:
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]


Nucleic acid sequence

        10         20         30         40         50         60
atgaagcgca ccccgactgc cgaggaacga gagcgcgaag ctaagaaact gaggcttctt
        70         80         90        100        110        120
gaagagcttg aagacacttg gctcccttat ctgaccccca aagatgatga attctatcag
       130        140        150        160        170        180
cagtggcagc tgaaatatcc taaactaatt ctccgagaag ccagcagtgt atctgaggag
       190        200        210        220        230        240
ctccataaag aggttcaaga agcctttctc acactgcaca agcatggctg cttatttcgg
       250        260        270        280        290        300
gacctggtta ggatccaagg caaagatctg ctcactccgg tatctcgcat cctcattggt
       310        320        330        340        350        360
aatccaggct gcacctacaa gtacctgaac accaggctct ttacggtccc ctggccagtg
       370        380        390        400        410        420
aaagggtcta atataaaaca caccgaggct gaaatagccg ctgcttgtga gaccttcctc
       430        440        450        460        470        480
aagctcaatg actacctgca gatagaaacc atccaggctt tggaagaact tgctgccaaa
       490        500        510        520        530        540
gagaaggcta atgaggatgc tgtgccattg tgtatgtctg cagatttccc cagggttggg
       550        560        570        580        590        600
atgggttcat cctacaacgg acaagatgaa gtggacatta agagcagagc agcatacaac
       610        620        630        640        650        660
gtaactttgc tgaatttcat ggatcctcag aaaatgccat acctgaaaga ggaaccttat
       670        680        690        700        710        720
tttggcatgg ggaaaatggc agtgagctgg catcatgatg aaaatctggt ggacaggtca
       730        740        750        760        770        780
gcggtggcag tgtacagtta tagctgtgaa ggccctgaag aggaaagtga ggatgactct
       790        800        810        820        830        840
catctcgaag gcagggatcc tgatatttgg catgttggtt ttaagatctc atgggacata
       850        860        870        880        890        900
gagacacctg gtttggcgat accccttcac caaggagact gctatttcat gcttgatgat
       910        920        930        940        950        960
ctcaatgcca cccaccaaca ctgtgttttg gccggttcac aacctcggtt tagttccacc
       970        980        990       1000       1010       1020
caccgagtgg cagagtgctc aacaggaacc ttggattata ttttacaacg ctgtcagttg
      1030       1040       1050       1060       1070       1080
gctctgcaga atgtctgtga cgatgtggac aatgatgatg tctctttgaa atcctttgag
      1090       1100       1110       1120       1130       1140
cctgcagttt tgaaacaagg agaagaaatt cataatgagg tcgagtttga gtggctgagg
      1150       1160       1170       1180       1190       1200
cagttttggt ttcaaggcaa tcgatacaga aagtgcactg actggtggtg tcaacccatg
      1210       1220       1230       1240       1250       1260
gctcaactgg aagcactgtg gaagaagatg gagggtgtga caaatgctgt gcttcatgaa
      1270       1280       1290       1300       1310       1320
gttaaaagag aggggctccc cgtggaacaa aggaatgaaa tcttgactgc catccttgcc
      1330       1340       1350       1360       1370       1380
tcgctcactg cacgccagaa cctgaggaga gaatggcatg ccaggtgcca gtcacgaatt
      1390       1400       1410       1420       1430       1440
gcccgaacat tacctgctga tcagaagcca gaatgtcggc catactggga aaaggatgat
      1450       1460       1470       1480       1490       1500
gcttcgatgc ctctgccgtt tgacctcaca gacatcgttt cagaactcag aggtcagctt
      1510
ctggaagcaa aaccctag    

Last modification date: Oct. 2, 2011