Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: DNA polymerase delta subunit 3


DESCRIPTION:
DNA polymerase delta (DNA polymerase III) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair.

MISCELLANEOUS:
Present with 2410 molecules/cell in log phase SD medium.


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MDQKASYFIN EKLFTEVKPV LFTDLIHHLK IGPSMAKKLM FDYYKQTTNA KYNCVVICCY
        70         80         90        100        110        120
KDQTIKIIHD LSNIPQQDSI IDCFIYAFNP MDSFIPYYDI IDQKDCLTIK NSYELKVSES
       130        140        150        160        170        180
SKIIERTKTL EEKSKPLVRP TARSKTTPEE TTGRKSKSKD MGLRSTALLA KMKKDRDDKE
       190        200        210        220        230        240
TSRQNELRKR KEENLQKINK QNPEREAQMK ELNNLFVEDD LDTEEVNGGS KPNSPKETDS
       250        260        270        280        290        300
NDKDKNNDDL EDLLETTAED SLMDVPKIQQ TKPSETEHSK EPKSEEEPSS FIDEDGYIVT
       310        320        330        340        350
KRPATSTPPR KPSPVVKRAL SSSKKQETPS SNKRLKKQGT LESFFKRKAK 

Encoded by POL32 gene


Nucleic acid sequence

        10         20         30         40         50         60
atggatcaaa aggcgtcata ttttatcaat gagaagctct tcactgaggt aaagcccgtc
        70         80         90        100        110        120
ctttttacgg atctaattca ccacttgaag atcggcccat ccatggccaa gaaattaatg
       130        140        150        160        170        180
tttgactatt acaaacagac caccaatgcc aaatacaact gcgtagtgat atgctgctac
       190        200        210        220        230        240
aaagatcaaa ctattaaaat tattcatgat ctttccaaca ttccacagca agattcaata
       250        260        270        280        290        300
attgattgtt tcatctatgc cttcaatccc atggacagct tcataccata ttacgacatt
       310        320        330        340        350        360
atcgatcaaa aggattgttt aaccattaaa aattcatacg aacttaaagt ttctgaatca
       370        380        390        400        410        420
tcgaaaatta tagagaggac taagacgtta gaagagaaat ctaaaccttt ggtaaggcct
       430        440        450        460        470        480
acagcaagat caaagaccac gccagaagaa acaaccggaa ggaaatccaa atctaaagac
       490        500        510        520        530        540
atgggtctca ggtctactgc actgctggct aagatgaaaa aggatagaga tgacaaggaa
       550        560        570        580        590        600
acctctagac aaaatgagtt acgtaaaagg aaagaggaga acttgcaaaa aataaataaa
       610        620        630        640        650        660
cagaaccctg aaagagaagc tcaaatgaaa gagttaaata atctttttgt cgaagatgac
       670        680        690        700        710        720
ttagatacag aggaagtaaa tggagggtcc aagcccaact cacctaaaga aactgacagc
       730        740        750        760        770        780
aacgataagg acaaaaacaa cgatgattta gaagacttgt tggaaacgac agcagaagat
       790        800        810        820        830        840
tcacttatgg atgtacctaa aatacagcaa acaaagcctt ctgaaacaga acattcaaag
       850        860        870        880        890        900
gaacctaaat ctgaagaaga gccctcctct tttattgatg aggatggata tattgtgaca
       910        920        930        940        950        960
aagagacccg caacttcaac accaccacgc aagccatcac ccgtggtaaa aagggcattg
       970        980        990       1000       1010       1020
tcgtcttcaa aaaagcaaga aacgccgtca tcgaataaaa ggttaaaaaa gcaaggaaca
      1030       1040       1050
ttggaaagct ttttcaaaag aaaggcaaaa taa  

Last modification date: Oct. 2, 2011