Saccharomyces cerevisiae Meyen ex E.C. Hansen (budding yeast) [SCE]

FULL NAME: DNA polymerase delta small subunit


DESCRIPTION:
DNA polymerase delta (DNA polymerase III) participates in chromosomal DNA replication. It is required during synthesis of the leading and lagging DNA strands at the replication fork and binds at/or near replication origins and moves along DNA with the replication fork. It has 3'-5' proofreading exonuclease activity that correct errors arising during DNA replication. It is also involved in DNA synthesis during DNA repair.

MISCELLANEOUS:
Present with 626 molecules/cell in log phase SD medium.


STRUCTURE SIMILARITY:
Belongs to the DNA polymerase delta/II small subunit family.


CATALYTIC ACTIVITY:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).


RELATED PATHWAY(S):
DNA replication
base excision repair (BER)
nucleotide excision repair (NER)
mismatch repair (MMR)
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MDALLTKFNE DRSLQDENLS QPRTRVRIVD DNLYNKSNPF QLCYKKRDYG SQYYHIYQYR
        70         80         90        100        110        120
LKTFRERVLK ECDKRWDAGF TLNGQLVLKK DKVLDIQGNQ PCWCVGSIYC EMKYKPNVLD
       130        140        150        160        170        180
EVINDTYGAP DLTKSYTDKE GGSDEIMLED ESGRVLLVGD FIRSTPFITG VVVGILGMEA
       190        200        210        220        230        240
EAGTFQVLDI CYPTPLPQNP FPAPIATCPT RGKIALVSGL NLNNTSPDRL LRLEILREFL
       250        260        270        280        290        300
MGRINNKIDD ISLIGRLLIC GNSVDFDIKS VNKDELMISL TEFSKFLHNI LPSISVDIMP
       310        320        330        340        350        360
GTNDPSDKSL PQQPFHKSLF DKSLESYFNG SNKEILNLVT NPYEFSYNGV DVLAVSGKNI
       370        380        390        400        410        420
NDICKYVIPS NDNGESENKV EEGESNDFKD DIEHRLDLME CTMKWQNIAP TAPDTLWCYP
       430        440        450        460        470        480
YTDKDPFVLD KWPHVYIVAN QPYFGTRVVE IGGKNIKIIS VPEFSSTGMI ILLDLETLEA

ETVKIDI     

Encoded by POL31 gene


OTHER NAME(S):
HUS2
HYS2
SDP5


Nucleic acid sequence

        10         20         30         40         50         60
atggacgcat tgttaacaaa gttcaacgag gatagaagtc tccaagatga aaacttgtcc
        70         80         90        100        110        120
caaccacgaa cgagagtaag aattgttgac gacaatcttt acaacaaatc gaatccattc
       130        140        150        160        170        180
caactatgct ataaaaaacg tgactacggt tctcagtact accacattta tcaataccgt
       190        200        210        220        230        240
ctaaagactt tcagagaacg cgtcttaaaa gaatgtgaca agagatggga tgcgggcttt
       250        260        270        280        290        300
accttgaatg gccaattagt tctaaaaaag gacaaagtgt tagatattca gggaaaccaa
       310        320        330        340        350        360
ccatgttggt gcgtaggatc catatattgc gagatgaaat ataaaccaaa cgtactggac
       370        380        390        400        410        420
gaagtgatca atgatacata tggtgcacca gatttaacta aaagttatac tgataaagag
       430        440        450        460        470        480
ggtggttctg atgaaattat gctcgaagat gaaagtggga gagtgcttct agtgggagat
       490        500        510        520        530        540
tttattcggt ctacaccctt catcacgggt gttgttgtag gtatactggg tatggaagct
       550        560        570        580        590        600
gaagccggga catttcaagt tttagacata tgctacccca ctcctttacc acaaaatcct
       610        620        630        640        650        660
ttccctgcac caattgctac ctgccccacc aggggaaaaa ttgctcttgt ttctgggtta
       670        680        690        700        710        720
aacctcaata atacatcacc tgataggcta ttgagattgg agattttgag agaatttttg
       730        740        750        760        770        780
atggggagaa tcaataacaa aattgacgac atttctctaa ttggtagatt actgatatgc
       790        800        810        820        830        840
ggcaactctg ttgacttcga cattaaaagc gtgaacaaag acgaattgat gatttctcta
       850        860        870        880        890        900
actgagttca gtaaatttct acacaacatt ttgccatcta tatctgttga tattatgccc
       910        920        930        940        950        960
ggaaccaatg atccaagtga caaatctcta ccgcaacagc ctttccacaa atcattgttt
       970        980        990       1000       1010       1020
gataagtccc tagaatcata cttcaacggt tctaacaaag aaattttgaa tttagtgacc
      1030       1040       1050       1060       1070       1080
aacccatatg agtttagcta taatggcgta gacgttctag ccgtttcagg caaaaatatc
      1090       1100       1110       1120       1130       1140
aatgatattt gtaaatacgt aataccatca aatgataacg gagaaagtga aaacaaggtc
      1150       1160       1170       1180       1190       1200
gaggagggcg agagtaatga tttcaaagac gatatagagc atcgcctgga ccttatggaa
      1210       1220       1230       1240       1250       1260
tgtacaatga aatggcaaaa catcgcgccc accgcacctg ataccttatg gtgttatccg
      1270       1280       1290       1300       1310       1320
tacactgata aggatccatt tgtattggat aagtggcccc acgtttacat tgtggcaaac
      1330       1340       1350       1360       1370       1380
cagccatatt ttggaacaag agtagtggaa ataggtggta agaacataaa gataatatct
      1390       1400       1410       1420       1430       1440
gtccctgaat tcagttctac tgggatgata atattactgg atttggaaac gttagaagca
      1450       1460
gagacggtca agattgacat ttaa   

Last modification date: Oct. 2, 2011