Mus musculus L. (mouse) [MMU]

FULL NAME: DNA topoisomerase


STRUCTURE SIMILARITY:
Belongs to the prokaryotic type I/III topoisomerase family.


CATALYTIC ACTIVITY:
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.


RELATED PATHWAY(S):
DNA replication
homologous recombination (HR)
Fanconi anemia (FA) pathway


Amino acids sequence

        10         20         30         40         50         60
MKTVLMVAEK PSLAQSIAKI LSRGNMSSHK GLNGACSVHK YTGTFAGQPV HFKMTSVCGH
        70         80         90        100        110        120
VMTLDFLGKY NKWDKVDPAE LFSQAPTEKK EANPKLNMVK FLQVEGRGCD YVVLWLDCDK
       130        140        150        160        170        180
EGENICFEVL DAVLPVMNNA HNGEKTVFRA RFSSITDTDI CNAMTRLSEP DHNEALSVDA
       190        200        210        220        230        240
RQELDLRIGC AFTRFQTKYF QGKYGDLDSS LISFGPCQTP TLGFCVERHD KIQSFKPETY
       250        260        270        280        290        300
WVLQAKVHTD KEESLLLDWD RVRVFDWEIA QMFLNMTKLE KEAWVEATSR KEKAKQRPLA
       310        320        330        340        350        360
LNTVEMLRVA SSALGMGPQH AMQIAERLYT QGYISYPRTE TTHYPENFDL KGSLRQQANH
       370        380        390        400        410        420
PYWADSVKQL LAEGINRPRK GHDAGDHPPI TPMKSATEAE LGGDAWRLYE YITRHFIATV
       430        440        450        460        470        480
SHDCKYLQST ISFRIGPEHF TCMGKTVISP GFTEIMPWQS VPLEESLPTC QKGDTFTVGE
       490        500        510        520        530        540
VKMLEKQTSP PDYLTEAELI TLMEKHGIGT DASIPVHINN ICQRNYVTVE SGRRLKPTNL
       550        560        570        580        590        600
GIVLVHGYYK IDAELVLPTI RSAVEKQLNL IAQGKADYHQ VLGHTLDIFK RKFHYFVDSI
       610        620        630        640        650        660
AGMDELMEVS FSPLAATGKP LSRCGKCHRF MKYIQAKPSR LHCSHCDETY TLPQNGTIKL
       670        680        690        700        710        720
YKELRCPLDD FELVLWSSGS RGKSYPLCPY CYNHPPFRDM KKGMGCNECT HPTCQHSLSM
       730        740        750        760        770        780
LGIGQCVECE NGVLVLDPTS GPKWKVACNT CNVVAHCFEN AHRVRVSADT CNTCEAALLD
       790        800        810        820        830        840
VDFNKAKSPL PGNETQHTGC IFCDPVFQEL VELKHAASCH PMHRGGPGRR QGRGRGRGRR
       850        860
PPGKPNPRRP KDKMSALAAY FV   

Encoded by Top3b gene

FULL NAME: topoisomerase (DNA) III beta


Nucleic acid sequence

        10         20         30         40         50         60
atgaagaccg tgctcatggt agcagaaaag ccatccctgg cacagtccat tgccaaaatc
        70         80         90        100        110        120
ctctcccgag gaaacatgtc ctcacacaaa gggctgaatg gggcatgttc agtgcacaag
       130        140        150        160        170        180
tacacaggaa cctttgctgg ccaacctgtc cacttcaaga tgacgtctgt ctgcggtcat
       190        200        210        220        230        240
gtgatgacac tggattttct ggggaagtac aacaagtggg ataaggtgga tcctgcagag
       250        260        270        280        290        300
ctcttcagcc aagctccaac agagaaaaag gaagctaacc ccaagctgaa catggtcaag
       310        320        330        340        350        360
ttcctgcagg tggagggcag aggctgtgac tatgttgtgc tgtggctgga ctgtgacaag
       370        380        390        400        410        420
gaaggggaga atatttgctt tgaggtcctt gatgccgttc tgcctgtcat gaataatgcc
       430        440        450        460        470        480
cacaatggtg agaagacagt gtttcgtgcc aggttcagct ccatcactga tacagacatc
       490        500        510        520        530        540
tgtaatgcca tgacccgcct gagcgagcca gaccacaatg aggcactctc agtggatgcc
       550        560        570        580        590        600
cgccaggagc tagacctgcg catcggctgt gcattcacta ggtttcaaac aaagtatttc
       610        620        630        640        650        660
cagggaaaat atggcgattt agacagctct ctcatctcct ttgggccatg tcagactcct
       670        680        690        700        710        720
accctgggat tctgtgtaga aagacatgat aaaatccagt ccttcaagcc agagacctac
       730        740        750        760        770        780
tgggtgcttc aggccaaggt tcatacagat aaagaggagt cactccttct ggactgggac
       790        800        810        820        830        840
cgtgttagag ttttcgactg ggagattgca cagatgtttt taaacatgac aaagttagaa
       850        860        870        880        890        900
aaagaagctt gggtggaggc tacaagcagg aaagaaaaag ccaagcagag accacttgct
       910        920        930        940        950        960
ctgaacactg tggagatgtt gcgtgtggcc agctcagctc tgggtatggg accacagcac
       970        980        990       1000       1010       1020
gccatgcaaa tagctgagag attatacaca cagggctata tcagctaccc acggacagaa
      1030       1040       1050       1060       1070       1080
accacccact atcccgagaa ctttgacctg aagggctctt tgcgacagca ggccaatcac
      1090       1100       1110       1120       1130       1140
ccatactggg cagactcggt aaagcagttg ttagcggaag gcatcaaccg ccctcggaaa
      1150       1160       1170       1180       1190       1200
ggtcatgatg ctggtgacca tcctccaatc acacctatga agtcggctac agaggctgaa
      1210       1220       1230       1240       1250       1260
ttaggaggtg acgcatggag actctacgag tatatcacca gacacttcat tgccacagtg
      1270       1280       1290       1300       1310       1320
agccatgact gcaagtatct ccagagcact atctccttca ggatcgggcc tgaacacttt
      1330       1340       1350       1360       1370       1380
acatgcatgg gaaaaacagt tatttctcca ggcttcacag agatcatgcc ttggcagagc
      1390       1400       1410       1420       1430       1440
gtgcccctgg aagagagtct gcccacgtgc cagaagggtg ataccttcac tgtgggtgaa
      1450       1460       1470       1480       1490       1500
gtgaagatgc tagagaagca gacgagccca ccggactatc tgactgaggc tgagctcatc
      1510       1520       1530       1540       1550       1560
actctcatgg agaagcatgg tatcgggact gatgccagta tccctgtgca catcaacaat
      1570       1580       1590       1600       1610       1620
atctgccagc gcaactatgt tactgtggag agtggccgcc gactcaagcc caccaacctt
      1630       1640       1650       1660       1670       1680
ggcatagttc tggtgcatgg ttactacaag attgatgcag agctggtact ccccaccatc
      1690       1700       1710       1720       1730       1740
cgaagcgcag tggagaagca gctgaatctt attgcccagg gcaaagctga ctaccaccaa
      1750       1760       1770       1780       1790       1800
gttctgggcc ataccctgga tatcttcaag agaaagttcc actacttcgt tgattctatt
      1810       1820       1830       1840       1850       1860
gctggcatgg acgagttgat ggaggtttcc ttttcacccc tggctgccac tggcaagccc
      1870       1880       1890       1900       1910       1920
ctctcacgct gtgggaagtg ccatcgattt atgaagtaca tccaggccaa gccaagtcgc
      1930       1940       1950       1960       1970       1980
ctgcactgct cccactgtga tgagacctac accctccccc agaatggtac catcaagctc
      1990       2000       2010       2020       2030       2040
tacaaggagc tgcggtgccc attggatgac tttgaactgg tcctgtggtc ctcaggctcc
      2050       2060       2070       2080       2090       2100
cggggcaaga gctacccact atgtccctac tgctataacc acccaccctt ccgagacatg
      2110       2120       2130       2140       2150       2160
aagaaaggca tgggctgcaa tgagtgcaca caccccacct gccagcactc actgagtatg
      2170       2180       2190       2200       2210       2220
ctgggcattg gccagtgcgt ggaatgcgag aatggagtcc ttgttctgga ccccacttct
      2230       2240       2250       2260       2270       2280
ggtcccaagt ggaaggtggc ctgcaataca tgcaatgtgg tggcacactg ctttgaaaat
      2290       2300       2310       2320       2330       2340
gcccaccgag tacgggtatc tgctgacacc tgcaacacct gcgaggctgc cttgctcgat
      2350       2360       2370       2380       2390       2400
gtagacttca acaaggccaa gtctcccctt cctggcaatg agacacagca cacaggctgc
      2410       2420       2430       2440       2450       2460
atcttctgtg accccgtctt ccaggagctg gtggagctta agcatgcagc ctcctgccac
      2470       2480       2490       2500       2510       2520
cccatgcacc gaggtgggcc tggaaggagg cagggtcgtg ggcggggccg gggccggaga
      2530       2540       2550       2560       2570       2580
cctccaggaa agcccaaccc taggcggcca aaagacaaga tgtcagctct ggctgcttac

tttgtatga     

Last modification date: Oct. 2, 2011