Mus musculus L. (mouse) [MMU]

FULL NAME: DNA repair protein RAD51 homolog 3


DESCRIPTION:
Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in the DNA repair process. Also has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis (By similarity). Essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability.

STRUCTURE SIMILARITY:
Belongs to the RecA family. RAD51 subfamily.


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MQRELVGYPL SPAVRGKLVA AGFQTAEDVL EVKPSELSKE VGISKEEALE TLQILRRECL
        70         80         90        100        110        120
TNKPRCAGTS VANEKCTALE LLEQEHTQGF IITFCSALDN ILGGGIPLMK TTEVCGVPGV
       130        140        150        160        170        180
GKTQLCMQLA VDVQIPECFG GVAGEAVFID TEGSFMVDRV VSLATACIQH LHLIAGTHTE
       190        200        210        220        230        240
EEHQKALKDF TLENILSHIY YFRCHDYTEL LAQVYLLPDF LSDHPKVQLV IIDGIAFPFR
       250        260        270        280        290        300
HDLEDLSLRT RLLNGLAQQM ISLANNHRLA VILTNQMTTK IDKNQALLVP ALGESWGHAA
       310        320        330        340        350        360
TIRLIFHWEQ KQRFATLYKS PSQKESTIPF QITPQGFRDA VVTAASSQTE SSLNFRKRSR

EPEEEC     

Encoded by Rad51c gene

FULL NAME: RAD51 homolog c (S. cerevisiae)


OTHER NAME(S):
Rad51l2
R51H3


Nucleic acid sequence

        10         20         30         40         50         60
atgcagcggg agttggtggg ttatccgctg tctccagcgg tgcgcgggaa gctggtggct
        70         80         90        100        110        120
gcggggtttc agacggcgga ggacgtccta gaggtgaagc cctccgagct cagcaaagaa
       130        140        150        160        170        180
gttgggatat ctaaagagga agccttggaa actctacaaa ttctaagaag agaatgtctc
       190        200        210        220        230        240
acaaataaac caagatgtgc cggtacatct gtggcaaacg agaagtgcac agcactggaa
       250        260        270        280        290        300
cttctcgagc aagagcatac ccagggcttc ataatcacct tctgttcagc actcgataac
       310        320        330        340        350        360
attcttgggg gtggaatacc cctaatgaag acgacagaag tttgtggtgt accaggtgtt
       370        380        390        400        410        420
ggaaaaacac agttatgtat gcaattggca gtagatgtgc agattccaga atgttttggg
       430        440        450        460        470        480
ggcgtggccg gtgaagcagt atttattgat acagagggaa gttttatggt tgatagagtg
       490        500        510        520        530        540
gtcagccttg caactgcctg cattcagcac cttcatctca tagcaggaac acacacggaa
       550        560        570        580        590        600
gaagaacatc agaaagcctt gaaggatttt actcttgaaa atattctttc ccatatttat
       610        620        630        640        650        660
tattttcgtt gtcatgatta tactgagctg ctggcacaag tctatctcct tccagatttc
       670        680        690        700        710        720
ctttcagatc atccaaaggt gcagctagtg ataatagacg gaattgcttt tccctttcgt
       730        740        750        760        770        780
catgaccttg aagatctatc ccttcgtact cgattactaa atggcctcgc ccaacaaatg
       790        800        810        820        830        840
atcagccttg caaataatca cagattagct gttattttaa ctaatcagat gacaacaaag
       850        860        870        880        890        900
attgataaaa atcaagcttt gcttgttcct gcattagggg aaagctgggg gcatgctgct
       910        920        930        940        950        960
acaataaggc tcatttttca ctgggaacaa aagcaaagat ttgcaacatt gtacaagtca
       970        980        990       1000       1010       1020
ccaagccaga aggagtctac gataccattt cagatcacac ctcagggatt tagagacgct
      1030       1040       1050       1060       1070       1080
gttgtcactg ctgcctcatc acagacagag agttctttga atttccggaa acggtcacga
      1090       1100
gaaccagagg aagaatgctg a   

Last modification date: Oct. 2, 2011