Caenorhabditis elegans Maupas (nematode) [CEL]

FULL NAME: DNA topoisomerase 3


STRUCTURE SIMILARITY:
Contains 1 Toprim domain.
Belongs to the prokaryotic type I/III topoisomerase family.


CATALYTIC ACTIVITY:
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.


PROTEIN TYPE(S):
endonuclease
DNA topoisomerase


RELATED PATHWAY(S):
DNA replication
homologous recombination (HR)
Fanconi anemia (FA) pathway


Amino acids sequence

        10         20         30         40         50         60
MKRALFVAEK NDVAKGVAAI LSNGTANRRE GRSKFNKIYT LNTELFGQQT AISVTSVSGH
        70         80         90        100        110        120
MMNFQFHENM SNWQTASMVE LFRAPVRHVV TPEMKLIEQT LREQAQRHDI LVVWTDCDRE
       130        140        150        160        170        180
GEAIGAEIVK VCRDSNRRLD IFRARFSEIT KAAITRAARN LIRLDEKTVA AVDCRSELDL
       190        200        210        220        230        240
RIGSAFTRLQ TLHLRNRFRD LLGQNDTSQV ISYGSCQFPT LGFVTDRYKM IENFVSEPFW
       250        260        270        280        290        300
KLIVEHTRES HKVEFLWDRN RLFDRDTVDI LHDECKETKE AHVEKVAKKP KSKWRPQALD
       310        320        330        340        350        360
TVELEKLGIS KLRMSAKQTM QVAEKLYSKG FISYPRTETN KFPAGLNLTP LVQQQTQSNI
       370        380        390        400        410        420
WGDFANEVLQ NGVNPRNGRK SDEAHPPIHP LKFTEKHQLQ GDDWKVYELV VRHFLACVSQ
       430        440        450        460        470        480
DAQGEETMVN LTVGTEKFHA SGLRIRDMGY LKVYVYEKWG NRLLPTYTEG ERFTDFELKI
       490        500        510        520        530        540
GDGKTQAPDF LTEADLISLM DKYGIGTDAT HAEHIEKIKT REYIGVRPDG KLIPSFLGLA
       550        560        570        580        590        600
LVDGYDDMGF AMSKPDLRAN LEIGLKEICD GRRQKQEVLD EQIGKYRAIF VESERKIGVL
       610        620        630        640        650        660
SQSLQRYLDK NNQAGGGPGG PGGGGGPPRG PGGGGGGGPT GPPAPPKPPA KPRGRPPRKS
       670        680        690        700        710        720
ISPAVKNGHD DPENDTIVTL SEVFGSMSNP KPARKPRAPR KSAAPKEQEE EEEVFCQCPE
       730        740        750
PMRAVTKVVQ KEGPNKGKKF YTCSLPYTSS EKCNFFKWA  

Encoded by top-3 gene

FULL NAME: TOPoisomerase


Nucleic acid sequence

        10         20         30         40         50         60
atgaaaagag ccttatttgt ggccgagaag aatgacgtgg caaagggagt cgctgcgatt
        70         80         90        100        110        120
ttatcaaatg gaacagcgaa tcgacgagag gggcggagca agtttaacaa gatttacacg
       130        140        150        160        170        180
ttgaataccg agctttttgg acagcaaacc gcaatttcgg tgacaagtgt ttcgggacat
       190        200        210        220        230        240
atgatgaatt tccaatttca cgagaatatg tcgaattggc aaacggcgtc gatggtcgag
       250        260        270        280        290        300
ttgtttcgag ctccggttcg gcatgttgtc acaccagaga tgaagctcat cgagcagaca
       310        320        330        340        350        360
ttaagagaac aagcccaacg acacgatatc ctggtagtct ggacagattg cgatcgagaa
       370        380        390        400        410        420
ggtgaagcaa ttggcgctga aattgttaaa gtttgcagag atagcaaccg gcggctggat
       430        440        450        460        470        480
attttcagag cgagattctc cgaaatcaca aaagcagcca tcacacgagc agctcggaat
       490        500        510        520        530        540
ctcatccgac tcgacgagaa gaccgttgcc gcagttgatt gtcgaagtga attggatctt
       550        560        570        580        590        600
cgaattggat ccgcttttac aagactacag acgttgcatt taaggaatcg attcagagat
       610        620        630        640        650        660
ttactggggc aaaatgacac atcccaagtg atcagctatg gctcctgtca attcccaaca
       670        680        690        700        710        720
ctcggctttg tcacagatcg ttataaaatg attgagaact ttgtgtccga accattctgg
       730        740        750        760        770        780
aagctgatcg tggagcacac ccgggagagc cataaagtcg aatttctatg ggatcggaat
       790        800        810        820        830        840
cgacttttcg atcgagacac tgtagatatt cttcatgatg agtgtaaaga aaccaaggaa
       850        860        870        880        890        900
gctcatgttg aaaaagtggc gaagaagccg aagagcaagt ggagaccgca ggctttggat
       910        920        930        940        950        960
acggttgaac tggaaaagct gggaatctcg aagcttagaa tgtcggctaa gcagacaatg
       970        980        990       1000       1010       1020
caagtggctg agaagttgta tagcaaggga tttatttcgt atccgaggac tgagacgaac
      1030       1040       1050       1060       1070       1080
aagtttccgg ctggattaaa cttgacaccg ttggtgcagc agcagacaca atcgaatatt
      1090       1100       1110       1120       1130       1140
tggggagatt ttgctaatga ggttctacaa aacggtgtaa atccgagaaa cggacgaaaa
      1150       1160       1170       1180       1190       1200
agcgacgaag cccatccacc gattcatcca ctcaaattca ctgaaaaaca ccagttacaa
      1210       1220       1230       1240       1250       1260
ggagacgatt ggaaagtcta tgagctcgtt gttcgtcatt ttttggcgtg tgtctcccag
      1270       1280       1290       1300       1310       1320
gatgctcaag gcgaagaaac aatggttaat ttaacagttg gaaccgagaa attccatgct
      1330       1340       1350       1360       1370       1380
tcaggccttc gaattagaga tatgggatat ttgaaagtgt atgtctatga gaaatggggt
      1390       1400       1410       1420       1430       1440
aatcgacttt tgccaactta cacggaagga gaacgattca ctgattttga gctgaaaatt
      1450       1460       1470       1480       1490       1500
ggagatggaa aaacacaggc gccggatttt ttgactgaag cggatttaat ctcactaatg
      1510       1520       1530       1540       1550       1560
gacaaatacg gaattggaac cgacgcaaca cacgccgaac acattgagaa aatcaagaca
      1570       1580       1590       1600       1610       1620
cgagaatata ttggagtacg tccagatgga aaattaattc catcattcct cggtctggca
      1630       1640       1650       1660       1670       1680
cttgtcgacg gttatgatga tatgggcttt gcaatgagta agcccgattt acgagccaat
      1690       1700       1710       1720       1730       1740
ttggaaatcg gcctgaaaga aatttgcgac ggtcgacgac agaaacaaga agttttggat
      1750       1760       1770       1780       1790       1800
gagcaaatcg gcaaatatcg agccattttt gtagagtctg aacgcaaaat tggcgtgctc
      1810       1820       1830       1840       1850       1860
tcgcaaagtt tgcaacgata tttggacaag aataatcagg ctggcggagg gcctggaggg
      1870       1880       1890       1900       1910       1920
cctggaggcg gtggaggccc accaagagga cctggaggtg gtggtggggg aggccctaca
      1930       1940       1950       1960       1970       1980
ggcccgccgg ctcctccaaa gccgcctgca aaaccacgtg gcaggccacc cagaaaatcg
      1990       2000       2010       2020       2030       2040
ataagcccag cagtgaagaa tgggcatgat gatccggaaa atgatacgat agtaacactg
      2050       2060       2070       2080       2090       2100
agcgaggtgt tcggcagtat gtccaacccg aaaccagcca gaaaaccacg tgctccacga
      2110       2120       2130       2140       2150       2160
aaaagtgctg ctccaaaaga acaggaagag gaagaggaag tgttctgcca gtgcccggag
      2170       2180       2190       2200       2210       2220
ccgatgagag ccgtcacgaa agtggtgcag aaggagggtc cgaataaggg aaaaaagttc
      2230       2240       2250       2260       2270       2280
tatacatgct cgttaccgta tacatcgtct gaaaaatgta atttctttaa atgggcttga

Last modification date: Oct. 2, 2011