Schizo-saccharomyces pombe Lindner (fission yeast) [SPO]

FULL NAME: DNA topoisomerase 3


STRUCTURE SIMILARITY:
Contains 1 Toprim domain.
Belongs to the prokaryotic type I/III topoisomerase family.


CATALYTIC ACTIVITY:
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.


PROTEIN TYPE(S):
endonuclease
DNA topoisomerase


RELATED PATHWAY(S):
DNA replication
homologous recombination (HR)
Fanconi anemia (FA) pathway


Amino acids sequence

        10         20         30         40         50         60
MRVLCVAEKN SIAKSVASIL GGGHVRRRDT RSKYVKNYDF SFNFGGNVGS SDVTMTSVSG
        70         80         90        100        110        120
HLTEASFPSE YSSWSSVPQD VLFDAQIITS VSKNAEVLAD NIKKEARNAQ YLYIWTDCDR
       130        140        150        160        170        180
EGEHIGVEIS NVARASNPSI QVIRADFNNL ERSHIISAAK RPRDVSKNAA DAVDARIELD
       190        200        210        220        230        240
FRLGAIFTRL QTIQLQKSFD ILQNKIISYG PCQFPTLGFV VDRWQRVEDF VPETYWHLRF
       250        260        270        280        290        300
VDKRQGKTIQ FNWERAKVFD RLTTMIILEN CLECKTAKVV NITQKPKTKY KPLPLSTVEL
       310        320        330        340        350        360
TKLGPKHLRI SAKKTLELAE NLYTNGFVSY PRTETDQFDS SMNLHAIIQK LTGAQEWDSY
       370        380        390        400        410        420
AEGLLAGDYR PPRKGKHNDR AHPPIHPVQM VHRSALPSQD HWKVYELITR RFLACCSDNA
       430        440        450        460        470        480
KGAETLVQVK MEEELFSKKG LLVTEKNYLE VYPYEKWESS DQLPEYRLHE EFQPHILDMM
       490        500        510        520        530        540
DSSTSSPSYI TEPELIALMD ANGIGTDATM AEHIEKVQER EYVIKRKKRG QGVTEFVPSS
       550        560        570        580        590        600
LGVALAKGYD EIGLEWSLTK PFLRKEMEVQ LKNIENGQLN RNVLVHMILT QFRDVFHLTK
       610        620
QRFDCLKNSC RVYLMSHNEP QT   

Encoded by top3 gene


Nucleic acid sequence

        10         20         30         40         50         60
atgcgcgtcc tatgtgttgc tgaaaaaaac tcgattgcca aatcggtagc aagcattcta
        70         80         90        100        110        120
gggggtggac acgtgagaag gagagataca cgaagtaagt atgtaaaaaa ttacgacttc
       130        140        150        160        170        180
tcatttaatt ttggaggcaa tgttggatct tctgatgtta caatgacttc tgtatccggt
       190        200        210        220        230        240
cacttaacag aagcttcttt tccttctgaa tattctagtt ggagctctgt ccctcaagac
       250        260        270        280        290        300
gttttattcg atgctcaaat catcacctca gtatcaaaga atgcagaagt actagcagac
       310        320        330        340        350        360
aatattaaaa aagaagctag aaatgcccag tacctttata tttggaccga ttgtgatcgt
       370        380        390        400        410        420
gagggtgaac acattggggt ggaaatctcc aatgtagcta gagccagcaa tccatctatt
       430        440        450        460        470        480
caggttatcc gagcagactt caataatttg gaacggtcac atattatcag tgccgcgaaa
       490        500        510        520        530        540
cgtccaagag atgtttcaaa aaatgctgca gatgctgtgg atgctagaat tgaacttgat
       550        560        570        580        590        600
tttcgtttag gtgcaatatt cactcggcta caaactattc aattacaaaa atcattcgat
       610        620        630        640        650        660
attcttcaga ataaaataat aagttatggt ccctgccaat tccctacatt aggctttgta
       670        680        690        700        710        720
gttgatcggt ggcagcgagt agaagacttt gtgcctgaaa cctactggca ccttcgattt
       730        740        750        760        770        780
gttgataaaa gacagggtaa gactattcag ttcaattggg aaagggccaa agtttttgac
       790        800        810        820        830        840
agattaacta caatgatcat cttggaaaac tgtttagaat gcaaaactgc taaggtcgtt
       850        860        870        880        890        900
aacataactc aaaaaccaaa aaccaagtat aaacctctgc cattatcaac tgtagaactt
       910        920        930        940        950        960
acaaaactgg ggccaaaaca tctaagaatt tctgctaaga aaactttaga gctcgccgaa
       970        980        990       1000       1010       1020
aacttatata ctaatgggtt tgtttcttac ccacgtactg aaaccgacca atttgactct
      1030       1040       1050       1060       1070       1080
tcaatgaatt tgcatgcgat tatccaaaaa ctaacaggtg cacaagaatg ggactcttat
      1090       1100       1110       1120       1130       1140
gcagaagggc ttttggctgg agattatcga ccgccccgaa aaggtaaaca caatgatcgc
      1150       1160       1170       1180       1190       1200
gctcatccac ctattcatcc cgttcaaatg gttcaccggt cagcgcttcc ttcccaagat
      1210       1220       1230       1240       1250       1260
cattggaaag tatatgagct aattacaaga agatttttag cttgttgttc tgacaatgcc
      1270       1280       1290       1300       1310       1320
aaaggagccg aaacgttggt gcaggttaaa atggaagaag agcttttttc taaaaaggga
      1330       1340       1350       1360       1370       1380
ttgctagtga cagagaaaaa ttatttagag gtttatccat atgagaaatg ggaaagttcg
      1390       1400       1410       1420       1430       1440
gatcaattac cagagtatag acttcacgag gaattccaac cccacattct cgacatgatg
      1450       1460       1470       1480       1490       1500
gacagttcaa cgtcctcccc ttcctatatc actgaaccgg agttaattgc cttgatggat
      1510       1520       1530       1540       1550       1560
gccaatggaa tcgggacaga tgctactatg gcagagcaca tcgaaaaagt tcaggagaga
      1570       1580       1590       1600       1610       1620
gaatatgtca taaaacgaaa aaaaaggggc caaggtgtaa ctgaatttgt accaagctct
      1630       1640       1650       1660       1670       1680
ttaggagttg ctttggcaaa aggctatgat gaaattggtt tagagtggag tttgaccaag
      1690       1700       1710       1720       1730       1740
cctttcttgc gaaaagaaat ggaagttcaa cttaaaaaca tagaaaatgg ccaacttaat
      1750       1760       1770       1780       1790       1800
cggaatgttc tagttcatat gatccttacc caattccgtg atgtttttca tctcacaaag
      1810       1820       1830       1840       1850       1860
caaagattcg attgtttaaa aaatagttgc agagtctacc ttatgagtca taatgaaccg

caaacctag     

Last modification date: Oct. 2, 2011