Homo sapiens L. (human) [HSA]

FULL NAME: DNA topoisomerase 3-beta-1


DESCRIPTION:
Possesses negatively supercoiled DNA relaxing activity.

STRUCTURE SIMILARITY:
Contains 1 Toprim domain.
Belongs to the prokaryotic type I/III topoisomerase family.


CATALYTIC ACTIVITY:
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.


PROTEIN TYPE(S):
endonuclease
DNA topoisomerase


RELATED PATHWAY(S):
DNA replication
homologous recombination (HR)
Fanconi anemia (FA) pathway


Amino acids sequence

        10         20         30         40         50         60
MKTVLMVAEK PSLAQSIAKI LSRGSLSSHK GLNGACSVHE YTGTFAGQPV RFKMTSVCGH
        70         80         90        100        110        120
VMTLDFLGKY NKWDKVDPAE LFSQAPTEKK EANPKLNMVK FLQVEGRGCD YIVLWLDCDK
       130        140        150        160        170        180
EGENICFEVL DAVLPVMNKA HGGEKTVFRA RFSSITDTDI CNAMACLGEP DHNEALSVDA
       190        200        210        220        230        240
RQELDLRIGC AFTRFQTKYF QGKYGDLDSS LISFGPCQTP TLGFCVERHD KIQSFKPETY
       250        260        270        280        290        300
WVLQAKVNTD KDRSLLLDWD RVRVFDREIA QMFLNMTKLE KEAQVEATSR KEKAKQRPLA
       310        320        330        340        350        360
LNTVEMLRVA SSSLGMGPQH AMQTAERLYT QGYISYPRTE TTHYPENFDL KGSLRQQANH
       370        380        390        400        410        420
PYWADTVKRL LAEGINRPRK GHDAGDHPPI TPMKSATEAE LGGDAWRLYE YITRHFIATV
       430        440        450        460        470        480
SHDCKYLQST ISFRIGPELF TCSGKTVLSP GFTEVMPWQS VPLEESLPTC QRGDAFPVGE
       490        500        510        520        530        540
VKMLEKQTNP PDYLTEAELI TLMEKHGIGT DASIPVHINN ICQRNYVTVE SGRRLKPTNL
       550        560        570        580        590        600
GIVLVHGYYK IDAELVLPTI RSAVEKQLNL IAQGKADYRQ VLGHTLDVFK RKFHYFVDSI
       610        620        630        640        650        660
AGMDELMEVS FSPLAATGKP LSRCGKCHRF MKYIQAKPSR LHCSHCDETY TLPQNGTIKL
       670        680        690        700        710        720
YKELRCPLDD FELVLWSSGS RGKSYPLCPY CYNHPPFRDM KKGMGCNECT HPSCQHSLSM
       730        740        750        760        770        780
LGIGQCVECE SGVLVLDPTS GPKWKVACNK CNVVAHCFEN AHRVRVSADT CSVCEAALLD
       790        800        810        820        830        840
VDFNKAKSPL PGDETQHMGC VFCDPVFQEL VELKHAASCH PMHRGGPGRR QGRGRGRARR
       850        860
PPGKPNPRRP KDKMSALAAY FV   

Encoded by TOP3B gene

FULL NAME: topoisomerase (DNA) III beta


OTHER NAME(S):
FLJ39376


DESCRIPTION:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgaagactg tgctcatggt tgctgaaaag ccgtccttgg cacagtcaat tgccaaaatc
        70         80         90        100        110        120
ctctctagag ggagcctgtc ctcacacaaa gggctgaacg gggcctgctc agtccacgag
       130        140        150        160        170        180
tacactggga cctttgctgg ccagccagtg cgcttcaaga tgacgtctgt ctgtggtcac
       190        200        210        220        230        240
gtgatgaccc tggatttcct gggaaaatac aacaaatggg acaaagtgga ccccgcagaa
       250        260        270        280        290        300
ctgttcagcc aagctcccac ggagaagaaa gaagctaacc ccaagctgaa catggtgaag
       310        320        330        340        350        360
ttcctgcagg tggagggcag aggctgcgac tacatcgtgc tgtggctgga ctgcgacaag
       370        380        390        400        410        420
gagggggaga acatctgctt tgaggttctt gatgctgttc tgcccgtcat gaacaaggcc
       430        440        450        460        470        480
catggtggcg agaagaccgt gttccgggcc aggtttagct ccatcacgga cacagacatc
       490        500        510        520        530        540
tgtaatgcca tggcctgcct aggcgagcct gaccacaacg aggcgctctc agtggatgct
       550        560        570        580        590        600
cgccaggagc tggacctgcg aatcggctgt gcattcacca ggtttcagac taaatatttc
       610        620        630        640        650        660
caggggaaat acggtgattt agacagctct ctcatctcct ttgggccgtg tcagactcca
       670        680        690        700        710        720
accctgggat tctgtgtgga gagacatgat aaaatccagt ccttcaaacc agagacctac
       730        740        750        760        770        780
tgggtgctgc aggccaaggt taacactgac aaagacagat ctctcctttt ggactgggac
       790        800        810        820        830        840
cgagtaagag tgtttgaccg ggagatcgca cagatgtttt taaacatgac aaagctggag
       850        860        870        880        890        900
aaggaagccc aggtggaggc cacaagcagg aaagaaaagg ccaagcagag gcccctggcc
       910        920        930        940        950        960
ctgaacactg tggagatgct gcgtgtggcc agctcttctc tgggcatggg gccgcagcac
       970        980        990       1000       1010       1020
gccatgcaga cggctgagcg gctctacacg caaggctaca tcagctaccc acggacagag
      1030       1040       1050       1060       1070       1080
accacccact accctgagaa ctttgacctg aagggctctc tgcggcagca ggccaaccac
      1090       1100       1110       1120       1130       1140
ccctactggg ccgacacggt gaagcggttg ttagcagaag gtatcaaccg cccgcggaaa
      1150       1160       1170       1180       1190       1200
ggccatgacg ccggcgacca tccccccatc acccccatga agtctgccac agaggccgaa
      1210       1220       1230       1240       1250       1260
ttagggggtg acgcgtggcg gctctatgag tacatcacca gacacttcat cgccacggtc
      1270       1280       1290       1300       1310       1320
agccatgact gcaagtacct gcagagcacc atctccttca gaattgggcc cgagctcttc
      1330       1340       1350       1360       1370       1380
acctgctccg ggaagaccgt cctctcacca ggcttcacgg aggtcatgcc ctggcagagc
      1390       1400       1410       1420       1430       1440
gtgcccctgg aggagagcct gcccacttgc cagcggggtg atgccttccc tgtgggcgag
      1450       1460       1470       1480       1490       1500
gtgaagatgc tggagaagca gacgaaccca cccgactacc tgacggaggc cgagctcatc
      1510       1520       1530       1540       1550       1560
acgctcatgg agaagcatgg catcggcacg gatgccagca tccctgtgca tatcaacaac
      1570       1580       1590       1600       1610       1620
atctgccagc gcaactatgt cacggtggag agcgggcgcc ggctcaagcc caccaacctc
      1630       1640       1650       1660       1670       1680
ggcatcgtcc tggtgcacgg ctactataag attgatgcag agctggtgct ccccaccatc
      1690       1700       1710       1720       1730       1740
cgcagtgcag tggagaagca gctgaacctg atcgcccagg gcaaggccga ctaccgccag
      1750       1760       1770       1780       1790       1800
gtcctgggcc acaccctgga cgtgttcaag aggaagttcc actactttgt cgactccatt
      1810       1820       1830       1840       1850       1860
gctggcatgg atgagttgat ggaggtgtct ttctcgcccc tggcggccac aggcaagccc
      1870       1880       1890       1900       1910       1920
ctctcacgct gtgggaagtg ccaccgcttc atgaagtaca tccaggccaa gccaagccgc
      1930       1940       1950       1960       1970       1980
ctgcactgct cccactgcga tgagacctac acgctccccc agaacggcac catcaagctc
      1990       2000       2010       2020       2030       2040
tacaaggagc tccgctgccc tctggatgac ttcgagctgg tcctgtggtc atcaggctct
      2050       2060       2070       2080       2090       2100
cggggcaaga gctacccgct gtgcccctac tgctacaacc acccaccctt ccgagacatg
      2110       2120       2130       2140       2150       2160
aagaaaggca tgggctgcaa cgagtgtacg cacccctcct gccagcactc gctgagcatg
      2170       2180       2190       2200       2210       2220
ctgggcatcg gccagtgcgt ggaatgtgag agcggggtgc tggtgctgga ccccacctcg
      2230       2240       2250       2260       2270       2280
ggccccaagt ggaaggtggc ctgcaacaag tgcaacgtgg tagcgcactg cttcgagaac
      2290       2300       2310       2320       2330       2340
gcccaccgcg tgcgggtgtc cgccgacacc tgcagtgtct gtgaggccgc cttgcttgat
      2350       2360       2370       2380       2390       2400
gtggacttca acaaggccaa gtccccactc ccgggcgatg agacgcagca catgggctgc
      2410       2420       2430       2440       2450       2460
gtcttttgtg accccgtctt ccaggagctg gtggagctga agcatgcggc ctcctgccac
      2470       2480       2490       2500       2510       2520
cccatgcacc gcggtggacc agggagaagg cagggtcgag ggcggggccg ggccaggagg
      2530       2540       2550       2560       2570       2580
ccccctggga agcccaaccc cagacggccc aaggacaaga tgtcagccct ggccgcctac

tttgtatga     

Last modification date: Oct. 2, 2011