Homo sapiens L. (human) [HSA]

FULL NAME: DNA topoisomerase 3-alpha


DESCRIPTION:
Reduces the number of supercoils in a highly negatively supercoiled DNA. Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells.

STRUCTURE SIMILARITY:
Contains 1 Toprim domain.
Belongs to the prokaryotic type I/III topoisomerase family.


CATALYTIC ACTIVITY:
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.


PROTEIN TYPE(S):
endonuclease
DNA topoisomerase


RELATED PATHWAY(S):
DNA replication
homologous recombination (HR)
Fanconi anemia (FA) pathway


RELATED DAMAGE:
intErstrand crosslinks (ICLs)


Amino acids sequence

        10         20         30         40         50         60
MIFPVARYAL RWLRRPEDRA FSRAAMEMAL RGVRKVLCVA EKNDAAKGIA DLLSNGRMRR
        70         80         90        100        110        120
REGLSKFNKI YEFDYHLYGQ NVTMVMTSVS GHLLAHDFQM QFRKWQSCNP LVLFEAEIEK
       130        140        150        160        170        180
YCPENFVDIK KTLERETRQC QALVIWTDCD REGENIGFEI IHVCKAVKPN LQVLRARFSE
       190        200        210        220        230        240
ITPHAVRTAC ENLTEPDQRV SDAVDVRQEL DLRIGAAFTR FQTLRLQRIF PEVLAEQLIS
       250        260        270        280        290        300
YGSCQFPTLG FVVERFKAIQ AFVPEIFHRI KVTHDHKDGI VEFNWKRHRL FNHTACLVLY
       310        320        330        340        350        360
QLCVEDPMAT VVEVRSKPKS KWRPQALDTV ELEKLASRKL RINAKETMRI AEKLYTQGYI
       370        380        390        400        410        420
SYPRTETNIF PRDLNLTVLV EQQTPDPRWG AFAQSILERG GPTPRNGNKS DQAHPPIHPT
       430        440        450        460        470        480
KYTNNLQGDE QRLYEFIVRH FLACCSQDAQ GQETTVEIDI AQERFVAHGL MILARNYLDV
       490        500        510        520        530        540
YPYDHWSDKI LPVYEQGSHF QPSTVEMVDG ETSPPKLLTE ADLIALMEKH GIGTDATHAE
       550        560        570        580        590        600
HIETIKARMY VGLTPDKRFL PGHLGMGLVE GYDSMGYEMS KPDLRAELEA DLKLICDGKK
       610        620        630        640        650        660
DKFVVLRQQV QKYKQVFIEA VAKAKKLDEA LAQYFGNGTE LAQQEDIYPA MPEPIRKCPQ
       670        680        690        700        710        720
CNKDMVLKTK KNGGFYLSCM GFPECRSAVW LPDSVLEASR DSSVCPVCQP HPVYRLKLKF
       730        740        750        760        770        780
KRGSLPPTMP LEFVCCIGGC DDTLREILDL RFSGGPPRAS QPSGRLQANQ SLNRMDNSQH
       790        800        810        820        830        840
PQPADSRQTG SSKALAQTLP PPTAAGESNS VTCNCGQEAV LLTVRKEGPN RGRQFFKCNG
       850        860        870        880        890        900
GSCNFFLWAD SPNPGAGGPP ALAYRPLGAS LGCPPGPGIH LGGFGNPGDG SGSGTSCLCS
       910        920        930        940        950        960
QPSVTRTVQK DGPNKGRQFH TCAKPREQQC GFFQWVDENT APGTSGAPSW TGDRGRTLES
       970        980        990       1000
EARSKRPRAS SSDMGSTAKK PRKCSLCHQP GHTRPFCPQN R 

Encoded by TOP3A gene

FULL NAME: topoisomerase (DNA) III alpha


OTHER NAME(S):
TOP3


DESCRIPTION:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgatctttc ctgtcgcccg ctacgcgctc cggtggctgc gacggcccga agaccgtgcc
        70         80         90        100        110        120
ttttcccgcg ccgccatgga gatggccctc cgaggcgtgc ggaaagtcct ctgtgtggcc
       130        140        150        160        170        180
gaaaaaaacg acgcggccaa ggggatcgcc gacctgctgt caaacggtcg catgaggcgg
       190        200        210        220        230        240
agagaaggac tttcaaaatt caacaagatc tatgaatttg attatcatct gtatggccag
       250        260        270        280        290        300
aatgttacca tggtaatgac ttcagtttct ggacatttac tggctcatga tttccagatg
       310        320        330        340        350        360
cagtttcgaa aatggcagag ctgcaaccct cttgtcctct ttgaagcaga aattgaaaag
       370        380        390        400        410        420
tactgcccag agaattttgt agacatcaag aaaactttgg aacgagagac tcgccagtgc
       430        440        450        460        470        480
caggctctgg tgatctggac tgactgtgat agagaaggcg aaaacatcgg gtttgagatt
       490        500        510        520        530        540
atccacgtgt gtaaggctgt aaagcccaat ctgcaggtgt tgcgagcccg attctctgag
       550        560        570        580        590        600
atcacacccc atgccgtcag gacagcttgt gaaaacctga ccgagcctga tcagagggtg
       610        620        630        640        650        660
agcgatgctg tggatgtgag gcaggagctg gacctgagga ttggagctgc ctttactagg
       670        680        690        700        710        720
ttccagaccc tgcggcttca gaggattttt cctgaggtgc tggcagagca gctcatcagt
       730        740        750        760        770        780
tacggcagct gccagttccc cacactgggc tttgtggtgg agcggttcaa agccattcag
       790        800        810        820        830        840
gcttttgtac cagaaatctt ccacagaatt aaagtaactc atgaccacaa agatggtatc
       850        860        870        880        890        900
gtagaattca actggaaaag gcatcgactc tttaaccaca cggcttgcct agttctctat
       910        920        930        940        950        960
cagttgtgtg tggaggatcc catggcaact gtggtagagg tcagatctaa gcccaagagc
       970        980        990       1000       1010       1020
aagtggcggc ctcaagcctt ggacactgtg gagcttgaga agctggcttc tcgaaagttg
      1030       1040       1050       1060       1070       1080
agaataaatg ctaaagaaac catgaggatt gctgagaagc tctacactca agggtacatc
      1090       1100       1110       1120       1130       1140
agctatcccc gaacagaaac aaacattttt cccagagact taaacctgac ggtgttggtg
      1150       1160       1170       1180       1190       1200
gaacagcaga cccccgatcc acgctggggg gcctttgccc agagcattct agagcggggt
      1210       1220       1230       1240       1250       1260
ggtcccaccc cacgcaatgg gaacaagtct gaccaagctc accctcccat tcaccccacc
      1270       1280       1290       1300       1310       1320
aaatacacca acaacttaca gggagatgaa cagcgactgt acgagtttat tgttcgccat
      1330       1340       1350       1360       1370       1380
ttcctggctt gctgctccca ggatgctcag gggcaggaga ccacagtgga gatcgacatc
      1390       1400       1410       1420       1430       1440
gctcaggaac gctttgtggc ccatggcctc atgattctgg cccgaaacta tctggatgtg
      1450       1460       1470       1480       1490       1500
tatccatatg atcactggag tgacaagatc ctccctgtct atgagcaagg atcccacttt
      1510       1520       1530       1540       1550       1560
cagcccagca ccgtggagat ggtggacggg gagaccagcc cacccaagct gctcaccgag
      1570       1580       1590       1600       1610       1620
gccgacctca ttgccctcat ggagaagcat ggcattggta cggatgccac tcatgcggag
      1630       1640       1650       1660       1670       1680
cacatcgaga ccatcaaagc ccggatgtac gtgggcctca ccccagacaa gcggttcctc
      1690       1700       1710       1720       1730       1740
cctgggcacc tgggcatggg acttgtggaa ggttatgatt ccatgggcta tgaaatgtct
      1750       1760       1770       1780       1790       1800
aagcctgacc tccgggctga actggaagct gatctgaagc tgatctgtga tggcaaaaag
      1810       1820       1830       1840       1850       1860
gacaaatttg tggttctaag gcagcaagtg cagaaataca agcaggtttt cattgaagcg
      1870       1880       1890       1900       1910       1920
gtggctaaag caaagaaatt ggacgaggcc ttggcccagt actttgggaa tgggacagag
      1930       1940       1950       1960       1970       1980
ttggcccagc aagaagatat ctacccagcc atgccagagc ccatcaggaa gtgcccacag
      1990       2000       2010       2020       2030       2040
tgcaacaagg acatggtcct taagaccaag aagaatggcg ggttctacct cagctgcatg
      2050       2060       2070       2080       2090       2100
ggtttcccag agtgtcgctc agctgtgtgg cttcctgact cggtgctgga ggccagcagg
      2110       2120       2130       2140       2150       2160
gacagcagtg tgtgtccagt ttgtcagcca caccctgtgt acaggttaaa gttaaagttt
      2170       2180       2190       2200       2210       2220
aagcgcggta gccttccccc gaccatgcct ctggagtttg tttgctgcat cggcggatgc
      2230       2240       2250       2260       2270       2280
gacgacaccc tgagggagat cctggacctg agattttcag ggggcccccc cagggctagc
      2290       2300       2310       2320       2330       2340
cagccctctg gccgcctgca ggctaaccag tccctgaaca ggatggacaa cagccagcac
      2350       2360       2370       2380       2390       2400
ccccagcctg ctgacagcag acagactggg tcctcaaagg ctctggccca gaccctccca
      2410       2420       2430       2440       2450       2460
ccacccacgg ctgctggtga aagcaattct gtgacctgca actgtggcca ggaggctgtg
      2470       2480       2490       2500       2510       2520
ctgctcactg tccgtaagga gggccccaac cggggccggc agttctttaa gtgcaacgga
      2530       2540       2550       2560       2570       2580
ggtagctgca acttcttcct gtgggcagac agccccaatc cgggagcagg agggcctcct
      2590       2600       2610       2620       2630       2640
gccttggcat atagacccct gggcgcctcc ctgggatgcc caccaggccc agggatccac
      2650       2660       2670       2680       2690       2700
ctaggtgggt ttggcaaccc tggtgatggc agtggtagtg gcacatcctg cctttgcagc
      2710       2720       2730       2740       2750       2760
cagccctccg tcacacggac tgtgcagaag gatggaccca acaaggggcg ccagttccac
      2770       2780       2790       2800       2810       2820
acatgtgcca agccgagaga gcagcagtgt ggctttttcc agtgggtcga tgagaacacc
      2830       2840       2850       2860       2870       2880
gctccaggga cttctggagc cccgtcctgg acaggagaca gaggaagaac cctggagtcg
      2890       2900       2910       2920       2930       2940
gaagccagaa gcaaaaggcc ccgggccagt tcctcagaca tggggtccac agcaaagaaa
      2950       2960       2970       2980       2990       3000
ccccggaaat gcagcctttg ccaccagcct ggacacaccc gtcccttttg tcctcagaac

agatga     

Last modification date: Oct. 2, 2011