Homo sapiens L. (human) [HSA]


RELATED PATHWAY(S):
homologous recombination (HR)


RELATED DISEASE(S):
breast cancer (BC)


Amino acids sequence

        10         20         30         40         50         60
MRRSLAPSQL AKRKPEGRSC DDEDWQPGLV TPRKRKSSSE TQIQECFLSP FRKPLSQLTN
        70         80         90        100        110        120
QPPCLDSSQH EAFIRSILSK PFKVPIPNYQ GPLGSRALGL KRAGVRRALH DPLEKDALVL
       130        140        150        160        170        180
YEPPPLSAHD QLKLDKEKLP VHVVVDPILS KVLRPHQREG VKFLWECVTS RRIPGSHGCI
       190        200        210        220        230        240
MADEMGLGKT LQCITLMWTL LRQSPECKPE IDKAVVVSPS SLVKNWYNEV GKWLGGRIQP
       250        260        270        280        290        300
LAIDGGSKDE IDQKLEGFMN QRGARVSSPI LIISYETFRL HVGVLQKGSV GLVICDEGHR
       310        320        330        340        350        360
LKNSENQTYQ ALDSLNTSRR VLISGTPIQN DLLEYFSLVH FVNSGILGTA HEFKKHFELP
       370        380        390        400        410        420
ILKGRDAAAS EADRQLGEER LRELTSIVNR CLIRRTSDIL SKYLPVKIEQ VVCCRLTPLQ
       430        440        450        460        470        480
TELYKRFLRQ AKPAEELLEG KMSVSSLSSI TSLKKLCNHP ALIYDKCVEE EDGFVGALDL
       490        500        510        520        530        540
FPPGYSSKAL EPQLSGKMLV LDYILAVTRS RSSDKVVLVS NYTQTLDLFE KLCRARRYLY
       550        560        570        580        590        600
VRLDGTMSIK KRAKVVERFN SPSSPDFVFM LSSKAGGCGL NLIGANRLVM FDPDWNPAND
       610        620        630        640        650        660
EQAMARVWRD GQKKTCYIYR LLSAGTIEEK IFQRQSHKKA LSSCVVDEEQ DVERHFSLGE
       670        680        690        700        710        720
LKELFILDEA SLSDTHDRLH CRRCVNSRQI RPPPDGSDCT SDLAGWNHCT DKWGLRDEVL
       730        740
QAAWDAASTA ITFVFHQRSH EEQRGLR   

Encoded by RAD54L gene

FULL NAME: RAD54-like (S. cerevisiae)


OTHER NAME(S):
HR54
RAD54A
hHR54
hRAD54


DESCRIPTION:
The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgaggagga gcttggctcc cagccagctg gccaagagaa aacctgaagg caggtcctgt
        70         80         90        100        110        120
gatgatgaag actggcaacc tggcctagtg actcctagga aacggaaatc cagcagtgag
       130        140        150        160        170        180
acccagatcc aggagtgttt cctgtctcct tttcggaaac ctttgagtca gctaaccaat
       190        200        210        220        230        240
caaccacctt gtctggacag cagtcagcat gaagcattta ttcgaagcat tttgtcaaag
       250        260        270        280        290        300
cctttcaaag tccccattcc aaattatcaa ggtcctctgg gctctcgagc attgggcctg
       310        320        330        340        350        360
aaaagggctg gggtccgccg ggccctccat gaccccctgg aaaaagatgc cttggttctg
       370        380        390        400        410        420
tatgagcctc ccccgctgag cgctcatgac cagctgaagc ttgacaagga gaaactccct
       430        440        450        460        470        480
gtccatgtgg ttgttgaccc tattctcagt aaggttttgc ggcctcatca gagagaggga
       490        500        510        520        530        540
gtgaaattcc tgtgggagtg tgtcaccagt cggcgcatcc ctggcagcca tggctgcatc
       550        560        570        580        590        600
atggctgatg agatgggcct aggaaagacg ctgcagtgca tcacattgat gtggacactt
       610        620        630        640        650        660
ttacgccaga gtccagagtg caagccagaa attgacaagg cagtggtggt gtcgccttcc
       670        680        690        700        710        720
agcctggtga agaactggta caatgaggtt gggaaatggc tcggagggag gatccaacct
       730        740        750        760        770        780
ctggccatcg atggaggatc taaggatgaa atagaccaaa agctggaagg attcatgaac
       790        800        810        820        830        840
cagcgtggag ccagggtgtc ttctcccatc ctcatcattt cctatgagac cttccgcctt
       850        860        870        880        890        900
catgttggag tcctccagaa aggaagtgtt ggtctggtca tatgtgacga gggacacagg
       910        920        930        940        950        960
ctcaagaact ctgagaatca gacttaccaa gccctggaca gcttgaacac cagccggcgg
       970        980        990       1000       1010       1020
gtgctcatct ccggaactcc catccagaat gatctgcttg agtatttcag cttggtacat
      1030       1040       1050       1060       1070       1080
tttgttaatt ccggcatcct agggactgcc catgaattca agaagcattt tgaattgcca
      1090       1100       1110       1120       1130       1140
attttgaagg gtcgagacgc tgctgctagt gaggcagaca ggcagctagg agaggagcgg
      1150       1160       1170       1180       1190       1200
ctgcgggagc tcaccagcat tgtgaataga tgcctgatac ggaggacttc tgatatcctt
      1210       1220       1230       1240       1250       1260
tctaaatatc tgcctgtgaa gattgagcag gtcgtttgtt gtaggctgac accccttcag
      1270       1280       1290       1300       1310       1320
actgagttat acaagaggtt tctgagacaa gccaaaccgg cagaagaatt gcttgagggc
      1330       1340       1350       1360       1370       1380
aagatgagtg tgtcttccct ttcttccatc acctcgctaa agaagctttg taatcatcca
      1390       1400       1410       1420       1430       1440
gctctaatct atgataagtg tgtggaagag gaggatggct ttgtgggtgc cttggacctc
      1450       1460       1470       1480       1490       1500
ttccctcctg gttacagctc taaggccctg gagccccagc tgtcaggtaa gatgctggtc
      1510       1520       1530       1540       1550       1560
ctggattata ttctggcggt gacccgaagc cgtagcagtg acaaagtagt gctggtgtcg
      1570       1580       1590       1600       1610       1620
aattacaccc agactttgga tctctttgag aagctgtgcc gtgcccgaag gtacttatac
      1630       1640       1650       1660       1670       1680
gtccgcctgg atggcacgat gtccattaag aagcgagcca aggttgtaga acgcttcaat
      1690       1700       1710       1720       1730       1740
agtccatcga gccctgactt tgtcttcatg ctgagcagca aagctggggg ctgtggcctc
      1750       1760       1770       1780       1790       1800
aatctcattg gggctaaccg gctggtcatg tttgaccctg actggaaccc agccaatgat
      1810       1820       1830       1840       1850       1860
gaacaagcca tggcccgggt ctggcgagat ggtcaaaaga agacttgcta tatctaccgc
      1870       1880       1890       1900       1910       1920
ctgctgtctg cagggaccat tgaggagaag atcttccagc gtcagagcca caagaaggca
      1930       1940       1950       1960       1970       1980
ctgagcagct gtgtggtgga tgaggagcag gatgtagagc gccacttctc tctgggcgag
      1990       2000       2010       2020       2030       2040
ttgaaggagc tgtttatcct ggatgaagct agcctcagtg acacacatga caggttgcac
      2050       2060       2070       2080       2090       2100
tgccgacgtt gtgtcaacag ccgtcagatc cggccacccc ctgatggttc tgactgcact
      2110       2120       2130       2140       2150       2160
tcagacctgg cagggtggaa ccactgcact gataagtggg ggctccggga tgaggtactc
      2170       2180       2190       2200       2210       2220
caggctgcct gggatgctgc ctccactgcc atcaccttcg tcttccacca gcgttctcat
      2230       2240
gaggagcagc ggggcctccg ctga   

Last modification date: Oct. 2, 2011