Homo sapiens L. (human) [HSA]

FULL NAME: DNA repair protein RAD51 homolog 3


DESCRIPTION:
Essential for the homologous recombination (HR) pathway of DNA repair. Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Participates in branch migration and Holliday junction resolution and thus is important for processing HR intermediates late in the DNA repair process. Also has an early function in DNA repair in facilitating phosphorylation of the checkpoint kinase CHK2 and thereby transduction of the damage signal, leading to cell cycle arrest and HR activation. Protects RAD51 from ubiquitin-mediated degradation that is enhanced following DNA damage. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and XRCC3. Contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Involved in maintaining centrosome number in mitosis.

STRUCTURE SIMILARITY:
Belongs to the RecA family. RAD51 subfamily.


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway
homologous recombination (HR)


Amino acids sequence

        10         20         30         40         50         60
MRGKTFRFEM QRDLVSFPLS PAVRVKLVSA GFQTAEELLE VKPSELSKEV GISKAEALET
        70         80         90        100        110        120
LQIIRRECLT NKPRYAGTSE SHKKCTALEL LEQEHTQGFI ITFCSALDDI LGGGVPLMKT
       130
TEICGAPGVG KTQLW    

Encoded by RAD51C gene

FULL NAME: RAD51 homolog C (S. cerevisiae)


OTHER NAME(S):
BROVCA3
FANCO
MGC104277
RAD51L2


DESCRIPTION:
This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgcgcggga agacgttccg ctttgaaatg cagcgggatt tggtgagttt cccgctgtct
        70         80         90        100        110        120
ccagcggtgc gggtgaagct ggtgtctgcg gggttccaga ctgctgagga actcctagag
       130        140        150        160        170        180
gtgaaaccct ccgagcttag caaagaagtt gggatatcta aagcagaagc cttagaaact
       190        200        210        220        230        240
ctgcaaatta tcagaagaga atgtctcaca aataaaccaa gatatgctgg tacatctgag
       250        260        270        280        290        300
tcacacaaga agtgtacagc actggaactt cttgagcagg agcataccca gggcttcata
       310        320        330        340        350        360
atcaccttct gttcagcact agatgatatt cttgggggtg gagtgccctt aatgaaaaca
       370        380        390        400
acagaaattt gtggtgcacc aggtgttgga aaaacacaat tatggtaa 

Last modification date: Oct. 2, 2011