Homo sapiens L. (human) [HSA]

FULL NAME: Breast cancer type 2 susceptibility protein


DESCRIPTION:
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. In concert with NPM1, regulates centrosome duplication.

STRUCTURE SIMILARITY:
Contains 8 BRCA2 repeats.


POST-TRANSLATIONAL MODIFICATION:
Ubiquitinated in the absence of DNA damage; this does not lead to proteasomal degradation. In contrast, ubiquitination in response to DNA damage leads to proteasomal degradation.
Phosphorylated by ATM upon irradiation-induced DNA damage.


RELATED PATHWAY(S):
Fanconi anemia (FA) pathway
homologous recombination (HR)


RELATED DISEASE(S):
pancreatic cancer type 2
Fanconi anemia, complementation group D1 (FANCD1)
glioma type 3
breast cancer (BC)
breast-ovarian cancer familial type 2 (BROVCA2)


Amino acids sequence

        10         20         30         40         50         60
MPIGSKERPT FFEIFKTRCN KADLGPISLN WFEELSSEAP PYNSEPAEES EHKNNNYEPN
        70         80         90        100        110        120
LFKTPQRKPS YNQLASTPII FKEQGLTLPL YQSPVKELDK FKLDLGRNVP NSRHKSLRTV
       130        140        150        160        170        180
KTKMDQADDV SCPLLNSCLS ESPVVLQCTH VTPQRDKSVV CGSLFHTPKF VKGRQTPKHI
       190        200        210        220        230        240
SESLGAEVDP DMSWSSSLAT PPTLSSTVLI VRNEEASETV FPHDTTANVK SYFSNHDESL
       250        260        270        280        290        300
KKNDRFIASV TDSENTNQRE AASHGFGKTS GNSFKVNSCK DHIGKSMPNV LEDEVYETVV
       310        320        330        340        350        360
DTSEEDSFSL CFSKCRTKNL QKVRTSKTRK KIFHEANADE CEKSKNQVKE KYSFVSEVEP
       370        380        390        400        410        420
NDTDPLDSNV ANQKPFESGS DKISKEVVPS LACEWSQLTL SGLNGAQMEK IPLLHISSCD
       430        440        450        460        470        480
QNISEKDLLD TENKRKKDFL TSENSLPRIS SLPKSEKPLN EETVVNKRDE EQHLESHTDC
       490        500        510        520        530        540
ILAVKQAISG TSPVASSFQG IKKSIFRIRE SPKETFNASF SGHMTDPNFK KETEASESGL
       550        560        570        580        590        600
EIHTVCSQKE DSLCPNLIDN GSWPATTTQN SVALKNAGLI STLKKKTNKF IYAIHDETSY
       610        620        630        640        650        660
KGKKIPKDQK SELINCSAQF EANAFEAPLT FANADSGLLH SSVKRSCSQN DSEEPTLSLT
       670        680        690        700        710        720
SSFGTILRKC SRNETCSNNT VISQDLDYKE AKCNKEKLQL FITPEADSLS CLQEGQCEND
       730        740        750        760        770        780
PKSKKVSDIK EEVLAAACHP VQHSKVEYSD TDFQSQKSLL YDHENASTLI LTPTSKDVLS
       790        800        810        820        830        840
NLVMISRGKE SYKMSDKLKG NNYESDVELT KNIPMEKNQD VCALNENYKN VELLPPEKYM
       850        860        870        880        890        900
RVASPSRKVQ FNQNTNLRVI QKNQEETTSI SKITVNPDSE ELFSDNENNF VFQVANERNN
       910        920        930        940        950        960
LALGNTKELH ETDLTCVNEP IFKNSTMVLY GDTGDKQATQ VSIKKDLVYV LAEENKNSVK
       970        980        990       1000       1010       1020
QHIKMTLGQD LKSDISLNID KIPEKNNDYM NKWAGLLGPI SNHSFGGSFR TASNKEIKLS
      1030       1040       1050       1060       1070       1080
EHNIKKSKMF FKDIEEQYPT SLACVEIVNT LALDNQKKLS KPQSINTVSA HLQSSVVVSD
      1090       1100       1110       1120       1130       1140
CKNSHITPQM LFSKQDFNSN HNLTPSQKAE ITELSTILEE SGSQFEFTQF RKPSYILQKS
      1150       1160       1170       1180       1190       1200
TFEVPENQMT ILKTTSEECR DADLHVIMNA PSIGQVDSSK QFEGTVEIKR KFAGLLKNDC
      1210       1220       1230       1240       1250       1260
NKSASGYLTD ENEVGFRGFY SAHGTKLNVS TEALQKAVKL FSDIENISEE TSAEVHPISL
      1270       1280       1290       1300       1310       1320
SSSKCHDSVV SMFKIENHND KTVSEKNNKC QLILQNNIEM TTGTFVEEIT ENYKRNTENE
      1330       1340       1350       1360       1370       1380
DNKYTAASRN SHNLEFDGSD SSKNDTVCIH KDETDLLFTD QHNICLKLSG QFMKEGNTQI
      1390       1400       1410       1420       1430       1440
KEDLSDLTFL EVAKAQEACH GNTSNKEQLT ATKTEQNIKD FETSDTFFQT ASGKNISVAK
      1450       1460       1470       1480       1490       1500
ESFNKIVNFF DQKPEELHNF SLNSELHSDI RKNKMDILSY EETDIVKHKI LKESVPVGTG
      1510       1520       1530       1540       1550       1560
NQLVTFQGQP ERDEKIKEPT LLGFHTASGK KVKIAKESLD KVKNLFDEKE QGTSEITSFS
      1570       1580       1590       1600       1610       1620
HQWAKTLKYR EACKDLELAC ETIEITAAPK CKEMQNSLNN DKNLVSIETV VPPKLLSDNL
      1630       1640       1650       1660       1670       1680
CRQTENLKTS KSIFLKVKVH ENVEKETAKS PATCYTNQSP YSVIENSALA FYTSCSRKTS
      1690       1700       1710       1720       1730       1740
VSQTSLLEAK KWLREGIFDG QPERINTADY VGNYLYENNS NSTIAENDKN HLSEKQDTYL
      1750       1760       1770       1780       1790       1800
SNSSMSNSYS YHSDEVYNDS GYLSKNKLDS GIEPVLKNVE DQKNTSFSKV ISNVKDANAY
      1810       1820       1830       1840       1850       1860
PQTVNEDICV EELVTSSSPC KNKNAAIKLS ISNSNNFEVG PPAFRIASGK IVCVSHETIK
      1870       1880       1890       1900       1910       1920
KVKDIFTDSF SKVIKENNEN KSKICQTKIM AGCYEALDDS EDILHNSLDN DECSTHSHKV
      1930       1940       1950       1960       1970       1980
FADIQSEEIL QHNQNMSGLE KVSKISPCDV SLETSDICKC SIGKLHKSVS SANTCGIFST
      1990       2000       2010       2020       2030       2040
ASGKSVQVSD ASLQNARQVF SEIEDSTKQV FSKVLFKSNE HSDQLTREEN TAIRTPEHLI
      2050       2060       2070       2080       2090       2100
SQKGFSYNVV NSSAFSGFST ASGKQVSILE SSLHKVKGVL EEFDLIRTEH SLHYSPTSRQ
      2110       2120       2130       2140       2150       2160
NVSKILPRVD KRNPEHCVNS EMEKTCSKEF KLSNNLNVEG GSSENNHSIK VSPYLSQFQQ
      2170       2180       2190       2200       2210       2220
DKQQLVLGTK VSLVENIHVL GKEQASPKNV KMEIGKTETF SDVPVKTNIE VCSTYSKDSE
      2230       2240       2250       2260       2270       2280
NYFETEAVEI AKAFMEDDEL TDSKLPSHAT HSLFTCPENE EMVLSNSRIG KRRGEPLILV
      2290       2300       2310       2320       2330       2340
GEPSIKRNLL NEFDRIIENQ EKSLKASKST PDGTIKDRRL FMHHVSLEPI TCVPFRTTKE
      2350       2360       2370       2380       2390       2400
RQEIQNPNFT APGQEFLSKS HLYEHLTLEK SSSNLAVSGH PFYQVSATRN EKMRHLITTG
      2410       2420       2430       2440       2450       2460
RPTKVFVPPF KTKSHFHRVE QCVRNINLEE NRQKQNIDGH GSDDSKNKIN DNEIHQFNKN
      2470       2480       2490       2500       2510       2520
NSNQAAAVTF TKCEEEPLDL ITSLQNARDI QDMRIKKKQR QRVFPQPGSL YLAKTSTLPR
      2530       2540       2550       2560       2570       2580
ISLKAAVGGQ VPSACSHKQL YTYGVSKHCI KINSKNAESF QFHTEDYFGK ESLWTGKGIQ
      2590       2600       2610       2620       2630       2640
LADGGWLIPS NDGKAGKEEF YRALCDTPGV DPKLISRIWV YNHYRWIIWK LAAMECAFPK
      2650       2660       2670       2680       2690       2700
EFANRCLSPE RVLLQLKYRY DTEIDRSRRS AIKKIMERDD TAAKTLVLCV SDIISLSANI
      2710       2720       2730       2740       2750       2760
SETSSNKTSS ADTQKVAIIE LTDGWYAVKA QLDPPLLAVL KNGRLTVGQK IILHGAELVG
      2770       2780       2790       2800       2810       2820
SPDACTPLEA PESLMLKISA NSTRPARWYT KLGFFPDPRP FPLPLSSLFS DGGNVGCVDV
      2830       2840       2850       2860       2870       2880
IIQRAYPIQW MEKTSSGLYI FRNEREEEKE AAKYVEAQQK RLEALFTKIQ EEFEEHEENT
      2890       2900       2910       2920       2930       2940
TKPYLPSRAL TRQQVRALQD GAELYEAVKN AADPAYLEGY FSEEQLRALN NHRQMLNDKK
      2950       2960       2970       2980       2990       3000
QAQIQLEIRK AMESAEQKEQ GLSRDVTTVW KLRIVSYSKK EKDSVILSIW RPSSDLYSLL
      3010       3020       3030       3040       3050       3060
TEGKRYRIYH LATSKSKSKS ERANIQLAAT KKTQYQQLPV SDEILFQIYQ PREPLHFSKF
      3070       3080       3090       3100       3110       3120
LDPDFQPSCS EVDLIGFVVS VVKKTGLAPF VYLSDECYNL LAIKFWIDLN EDIIKPHMLI
      3130       3140       3150       3160       3170       3180
AASNLQWRPE SKSGLLTLFA GDFSVFSASP KEGHFQETFN KMKNTVENID ILCNEAENKL
      3190       3200       3210       3220       3230       3240
MHILHANDPK WSTPTKDCTS GPYTAQIIPG TGNKLLMSSP NCEIYYQSPL SLCMAKRKSV
      3250       3260       3270       3280       3290       3300
STPVSAQMTS KSCKGEKEID DQKNCKKRRA LDFLSRLPLP PPVSPICTFV SPAAQKAFQP
      3310       3320       3330       3340       3350       3360
PRSCGTKYET PIKKKELNSP QMTPFKKFNE ISLLESNSIA DEELALINTQ ALLSGSTGEK
      3370       3380       3390       3400       3410
QFISVSESTR TAPTSSEDYL RLKRRCTTSL IKEQESSQAS TEECEKNKQD TITTKKYI

Encoded by BRCA2 gene

FULL NAME: breast cancer 2, early onset


OTHER NAME(S):
BRCC2
BROVCA2
FACD
FAD
FAD1
FANCB
FANCD
FANCD1
GLM3
PNCA2


DESCRIPTION:
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]


Nucleic acid sequence

        10         20         30         40         50         60
atgcctattg gatccaaaga gaggccaaca ttttttgaaa tttttaagac acgctgcaac
        70         80         90        100        110        120
aaagcagatt taggaccaat aagtcttaat tggtttgaag aactttcttc agaagctcca
       130        140        150        160        170        180
ccctataatt ctgaacctgc agaagaatct gaacataaaa acaacaatta cgaaccaaac
       190        200        210        220        230        240
ctatttaaaa ctccacaaag gaaaccatct tataatcagc tggcttcaac tccaataata
       250        260        270        280        290        300
ttcaaagagc aagggctgac tctgccgctg taccaatctc ctgtaaaaga attagataaa
       310        320        330        340        350        360
ttcaaattag acttaggaag gaatgttccc aatagtagac ataaaagtct tcgcacagtg
       370        380        390        400        410        420
aaaactaaaa tggatcaagc agatgatgtt tcctgtccac ttctaaattc ttgtcttagt
       430        440        450        460        470        480
gaaagtcctg ttgttctaca atgtacacat gtaacaccac aaagagataa gtcagtggta
       490        500        510        520        530        540
tgtgggagtt tgtttcatac accaaagttt gtgaagggtc gtcagacacc aaaacatatt
       550        560        570        580        590        600
tctgaaagtc taggagctga ggtggatcct gatatgtctt ggtcaagttc tttagctaca
       610        620        630        640        650        660
ccacccaccc ttagttctac tgtgctcata gtcagaaatg aagaagcatc tgaaactgta
       670        680        690        700        710        720
tttcctcatg atactactgc taatgtgaaa agctattttt ccaatcatga tgaaagtctg
       730        740        750        760        770        780
aagaaaaatg atagatttat cgcttctgtg acagacagtg aaaacacaaa tcaaagagaa
       790        800        810        820        830        840
gctgcaagtc atggatttgg aaaaacatca gggaattcat ttaaagtaaa tagctgcaaa
       850        860        870        880        890        900
gaccacattg gaaagtcaat gccaaatgtc ctagaagatg aagtatatga aacagttgta
       910        920        930        940        950        960
gatacctctg aagaagatag tttttcatta tgtttttcta aatgtagaac aaaaaatcta
       970        980        990       1000       1010       1020
caaaaagtaa gaactagcaa gactaggaaa aaaattttcc atgaagcaaa cgctgatgaa
      1030       1040       1050       1060       1070       1080
tgtgaaaaat ctaaaaacca agtgaaagaa aaatactcat ttgtatctga agtggaacca
      1090       1100       1110       1120       1130       1140
aatgatactg atccattaga ttcaaatgta gcaaatcaga agccctttga gagtggaagt
      1150       1160       1170       1180       1190       1200
gacaaaatct ccaaggaagt tgtaccgtct ttggcctgtg aatggtctca actaaccctt
      1210       1220       1230       1240       1250       1260
tcaggtctaa atggagccca gatggagaaa atacccctat tgcatatttc ttcatgtgac
      1270       1280       1290       1300       1310       1320
caaaatattt cagaaaaaga cctattagac acagagaaca aaagaaagaa agattttctt
      1330       1340       1350       1360       1370       1380
acttcagaga attctttgcc acgtatttct agcctaccaa aatcagagaa gccattaaat
      1390       1400       1410       1420       1430       1440
gaggaaacag tggtaaataa gagagatgaa gagcagcatc ttgaatctca tacagactgc
      1450       1460       1470       1480       1490       1500
attcttgcag taaagcaggc aatatctgga acttctccag tggcttcttc atttcagggt
      1510       1520       1530       1540       1550       1560
atcaaaaagt ctatattcag aataagagaa tcacctaaag agactttcaa tgcaagtttt
      1570       1580       1590       1600       1610       1620
tcaggtcata tgactgatcc aaactttaaa aaagaaactg aagcctctga aagtggactg
      1630       1640       1650       1660       1670       1680
gaaatacata ctgtttgctc acagaaggag gactccttat gtccaaattt aattgataat
      1690       1700       1710       1720       1730       1740
ggaagctggc cagccaccac cacacagaat tctgtagctt tgaagaatgc aggtttaata
      1750       1760       1770       1780       1790       1800
tccactttga aaaagaaaac aaataagttt atttatgcta tacatgatga aacatcttat
      1810       1820       1830       1840       1850       1860
aaaggaaaaa aaataccgaa agaccaaaaa tcagaactaa ttaactgttc agcccagttt
      1870       1880       1890       1900       1910       1920
gaagcaaatg cttttgaagc accacttaca tttgcaaatg ctgattcagg tttattgcat
      1930       1940       1950       1960       1970       1980
tcttctgtga aaagaagctg ttcacagaat gattctgaag aaccaacttt gtccttaact
      1990       2000       2010       2020       2030       2040
agctcttttg ggacaattct gaggaaatgt tctagaaatg aaacatgttc taataataca
      2050       2060       2070       2080       2090       2100
gtaatctctc aggatcttga ttataaagaa gcaaaatgta ataaggaaaa actacagtta
      2110       2120       2130       2140       2150       2160
tttattaccc cagaagctga ttctctgtca tgcctgcagg aaggacagtg tgaaaatgat
      2170       2180       2190       2200       2210       2220
ccaaaaagca aaaaagtttc agatataaaa gaagaggtct tggctgcagc atgtcaccca
      2230       2240       2250       2260       2270       2280
gtacaacatt caaaagtgga atacagtgat actgactttc aatcccagaa aagtctttta
      2290       2300       2310       2320       2330       2340
tatgatcatg aaaatgccag cactcttatt ttaactccta cttccaagga tgttctgtca
      2350       2360       2370       2380       2390       2400
aacctagtca tgatttctag aggcaaagaa tcatacaaaa tgtcagacaa gctcaaaggt
      2410       2420       2430       2440       2450       2460
aacaattatg aatctgatgt tgaattaacc aaaaatattc ccatggaaaa gaatcaagat
      2470       2480       2490       2500       2510       2520
gtatgtgctt taaatgaaaa ttataaaaac gttgagctgt tgccacctga aaaatacatg
      2530       2540       2550       2560       2570       2580
agagtagcat caccttcaag aaaggtacaa ttcaaccaaa acacaaatct aagagtaatc
      2590       2600       2610       2620       2630       2640
caaaaaaatc aagaagaaac tacttcaatt tcaaaaataa ctgtcaatcc agactctgaa
      2650       2660       2670       2680       2690       2700
gaacttttct cagacaatga gaataatttt gtcttccaag tagctaatga aaggaataat
      2710       2720       2730       2740       2750       2760
cttgctttag gaaatactaa ggaacttcat gaaacagact tgacttgtgt aaacgaaccc
      2770       2780       2790       2800       2810       2820
attttcaaga actctaccat ggttttatat ggagacacag gtgataaaca agcaacccaa
      2830       2840       2850       2860       2870       2880
gtgtcaatta aaaaagattt ggtttatgtt cttgcagagg agaacaaaaa tagtgtaaag
      2890       2900       2910       2920       2930       2940
cagcatataa aaatgactct aggtcaagat ttaaaatcgg acatctcctt gaatatagat
      2950       2960       2970       2980       2990       3000
aaaataccag aaaaaaataa tgattacatg aacaaatggg caggactctt aggtccaatt
      3010       3020       3030       3040       3050       3060
tcaaatcaca gttttggagg tagcttcaga acagcttcaa ataaggaaat caagctctct
      3070       3080       3090       3100       3110       3120
gaacataaca ttaagaagag caaaatgttc ttcaaagata ttgaagaaca atatcctact
      3130       3140       3150       3160       3170       3180
agtttagctt gtgttgaaat tgtaaatacc ttggcattag ataatcaaaa gaaactgagc
      3190       3200       3210       3220       3230       3240
aagcctcagt caattaatac tgtatctgca catttacaga gtagtgtagt tgtttctgat
      3250       3260       3270       3280       3290       3300
tgtaaaaata gtcatataac ccctcagatg ttattttcca agcaggattt taattcaaac
      3310       3320       3330       3340       3350       3360
cataatttaa cacctagcca aaaggcagaa attacagaac tttctactat attagaagaa
      3370       3380       3390       3400       3410       3420
tcaggaagtc agtttgaatt tactcagttt agaaaaccaa gctacatatt gcagaagagt
      3430       3440       3450       3460       3470       3480
acatttgaag tgcctgaaaa ccagatgact atcttaaaga ccacttctga ggaatgcaga
      3490       3500       3510       3520       3530       3540
gatgctgatc ttcatgtcat aatgaatgcc ccatcgattg gtcaggtaga cagcagcaag
      3550       3560       3570       3580       3590       3600
caatttgaag gtacagttga aattaaacgg aagtttgctg gcctgttgaa aaatgactgt
      3610       3620       3630       3640       3650       3660
aacaaaagtg cttctggtta tttaacagat gaaaatgaag tggggtttag gggcttttat
      3670       3680       3690       3700       3710       3720
tctgctcatg gcacaaaact gaatgtttct actgaagctc tgcaaaaagc tgtgaaactg
      3730       3740       3750       3760       3770       3780
tttagtgata ttgagaatat tagtgaggaa acttctgcag aggtacatcc aataagttta
      3790       3800       3810       3820       3830       3840
tcttcaagta aatgtcatga ttctgttgtt tcaatgttta agatagaaaa tcataatgat
      3850       3860       3870       3880       3890       3900
aaaactgtaa gtgaaaaaaa taataaatgc caactgatat tacaaaataa tattgaaatg
      3910       3920       3930       3940       3950       3960
actactggca cttttgttga agaaattact gaaaattaca agagaaatac tgaaaatgaa
      3970       3980       3990       4000       4010       4020
gataacaaat atactgctgc cagtagaaat tctcataact tagaatttga tggcagtgat
      4030       4040       4050       4060       4070       4080
tcaagtaaaa atgatactgt ttgtattcat aaagatgaaa cggacttgct atttactgat
      4090       4100       4110       4120       4130       4140
cagcacaaca tatgtcttaa attatctggc cagtttatga aggagggaaa cactcagatt
      4150       4160       4170       4180       4190       4200
aaagaagatt tgtcagattt aacttttttg gaagttgcga aagctcaaga agcatgtcat
      4210       4220       4230       4240       4250       4260
ggtaatactt caaataaaga acagttaact gctactaaaa cggagcaaaa tataaaagat
      4270       4280       4290       4300       4310       4320
tttgagactt ctgatacatt ttttcagact gcaagtggga aaaatattag tgtcgccaaa
      4330       4340       4350       4360       4370       4380
gagtcattta ataaaattgt aaatttcttt gatcagaaac cagaagaatt gcataacttt
      4390       4400       4410       4420       4430       4440
tccttaaatt ctgaattaca ttctgacata agaaagaaca aaatggacat tctaagttat
      4450       4460       4470       4480       4490       4500
gaggaaacag acatagttaa acacaaaata ctgaaagaaa gtgtcccagt tggtactgga
      4510       4520       4530       4540       4550       4560
aatcaactag tgaccttcca gggacaaccc gaacgtgatg aaaagatcaa agaacctact
      4570       4580       4590       4600       4610       4620
ctattgggtt ttcatacagc tagcgggaaa aaagttaaaa ttgcaaagga atctttggac
      4630       4640       4650       4660       4670       4680
aaagtgaaaa acctttttga tgaaaaagag caaggtacta gtgaaatcac cagttttagc
      4690       4700       4710       4720       4730       4740
catcaatggg caaagaccct aaagtacaga gaggcctgta aagaccttga attagcatgt
      4750       4760       4770       4780       4790       4800
gagaccattg agatcacagc tgccccaaag tgtaaagaaa tgcagaattc tctcaataat
      4810       4820       4830       4840       4850       4860
gataaaaacc ttgtttctat tgagactgtg gtgccaccta agctcttaag tgataattta
      4870       4880       4890       4900       4910       4920
tgtagacaaa ctgaaaatct caaaacatca aaaagtatct ttttgaaagt taaagtacat
      4930       4940       4950       4960       4970       4980
gaaaatgtag aaaaagaaac agcaaaaagt cctgcaactt gttacacaaa tcagtcccct
      4990       5000       5010       5020       5030       5040
tattcagtca ttgaaaattc agccttagct ttttacacaa gttgtagtag aaaaacttct
      5050       5060       5070       5080       5090       5100
gtgagtcaga cttcattact tgaagcaaaa aaatggctta gagaaggaat atttgatggt
      5110       5120       5130       5140       5150       5160
caaccagaaa gaataaatac tgcagattat gtaggaaatt atttgtatga aaataattca
      5170       5180       5190       5200       5210       5220
aacagtacta tagctgaaaa tgacaaaaat catctctccg aaaaacaaga tacttattta
      5230       5240       5250       5260       5270       5280
agtaacagta gcatgtctaa cagctattcc taccattctg atgaggtata taatgattca
      5290       5300       5310       5320       5330       5340
ggatatctct caaaaaataa acttgattct ggtattgagc cagtattgaa gaatgttgaa
      5350       5360       5370       5380       5390       5400
gatcaaaaaa acactagttt ttccaaagta atatccaatg taaaagatgc aaatgcatac
      5410       5420       5430       5440       5450       5460
ccacaaactg taaatgaaga tatttgcgtt gaggaacttg tgactagctc ttcaccctgc
      5470       5480       5490       5500       5510       5520
aaaaataaaa atgcagccat taaattgtcc atatctaata gtaataattt tgaggtaggg
      5530       5540       5550       5560       5570       5580
ccacctgcat ttaggatagc cagtggtaaa atcgtttgtg tttcacatga aacaattaaa
      5590       5600       5610       5620       5630       5640
aaagtgaaag acatatttac agacagtttc agtaaagtaa ttaaggaaaa caacgagaat
      5650       5660       5670       5680       5690       5700
aaatcaaaaa tttgccaaac gaaaattatg gcaggttgtt acgaggcatt ggatgattca
      5710       5720       5730       5740       5750       5760
gaggatattc ttcataactc tctagataat gatgaatgta gcacgcattc acataaggtt
      5770       5780       5790       5800       5810       5820
tttgctgaca ttcagagtga agaaatttta caacataacc aaaatatgtc tggattggag
      5830       5840       5850       5860       5870       5880
aaagtttcta aaatatcacc ttgtgatgtt agtttggaaa cttcagatat atgtaaatgt
      5890       5900       5910       5920       5930       5940
agtataggga agcttcataa gtcagtctca tctgcaaata cttgtgggat ttttagcaca
      5950       5960       5970       5980       5990       6000
gcaagtggaa aatctgtcca ggtatcagat gcttcattac aaaacgcaag acaagtgttt
      6010       6020       6030       6040       6050       6060
tctgaaatag aagatagtac caagcaagtc ttttccaaag tattgtttaa aagtaacgaa
      6070       6080       6090       6100       6110       6120
cattcagacc agctcacaag agaagaaaat actgctatac gtactccaga acatttaata
      6130       6140       6150       6160       6170       6180
tcccaaaaag gcttttcata taatgtggta aattcatctg ctttctctgg atttagtaca
      6190       6200       6210       6220       6230       6240
gcaagtggaa agcaagtttc cattttagaa agttccttac acaaagttaa gggagtgtta
      6250       6260       6270       6280       6290       6300
gaggaatttg atttaatcag aactgagcat agtcttcact attcacctac gtctagacaa
      6310       6320       6330       6340       6350       6360
aatgtatcaa aaatacttcc tcgtgttgat aagagaaacc cagagcactg tgtaaactca
      6370       6380       6390       6400       6410       6420
gaaatggaaa aaacctgcag taaagaattt aaattatcaa ataacttaaa tgttgaaggt
      6430       6440       6450       6460       6470       6480
ggttcttcag aaaataatca ctctattaaa gtttctccat atctctctca atttcaacaa
      6490       6500       6510       6520       6530       6540
gacaaacaac agttggtatt aggaaccaaa gtgtcacttg ttgagaacat tcatgttttg
      6550       6560       6570       6580       6590       6600
ggaaaagaac aggcttcacc taaaaacgta aaaatggaaa ttggtaaaac tgaaactttt
      6610       6620       6630       6640       6650       6660
tctgatgttc ctgtgaaaac aaatatagaa gtttgttcta cttactccaa agattcagaa
      6670       6680       6690       6700       6710       6720
aactactttg aaacagaagc agtagaaatt gctaaagctt ttatggaaga tgatgaactg
      6730       6740       6750       6760       6770       6780
acagattcta aactgccaag tcatgccaca cattctcttt ttacatgtcc cgaaaatgag
      6790       6800       6810       6820       6830       6840
gaaatggttt tgtcaaattc aagaattgga aaaagaagag gagagcccct tatcttagtg
      6850       6860       6870       6880       6890       6900
ggagaaccct caatcaaaag aaacttatta aatgaatttg acaggataat agaaaatcaa
      6910       6920       6930       6940       6950       6960
gaaaaatcct taaaggcttc aaaaagcact ccagatggca caataaaaga tcgaagattg
      6970       6980       6990       7000       7010       7020
tttatgcatc atgtttcttt agagccgatt acctgtgtac cctttcgcac aactaaggaa
      7030       7040       7050       7060       7070       7080
cgtcaagaga tacagaatcc aaattttacc gcacctggtc aagaatttct gtctaaatct
      7090       7100       7110       7120       7130       7140
catttgtatg aacatctgac tttggaaaaa tcttcaagca atttagcagt ttcaggacat
      7150       7160       7170       7180       7190       7200
ccattttatc aagtttctgc tacaagaaat gaaaaaatga gacacttgat tactacaggc
      7210       7220       7230       7240       7250       7260
agaccaacca aagtctttgt tccacctttt aaaactaaat cacattttca cagagttgaa
      7270       7280       7290       7300       7310       7320
cagtgtgtta ggaatattaa cttggaggaa aacagacaaa agcaaaacat tgatggacat
      7330       7340       7350       7360       7370       7380
ggctctgatg atagtaaaaa taagattaat gacaatgaga ttcatcagtt taacaaaaac
      7390       7400       7410       7420       7430       7440
aactccaatc aagcagcagc tgtaactttc acaaagtgtg aagaagaacc tttagattta
      7450       7460       7470       7480       7490       7500
attacaagtc ttcagaatgc cagagatata caggatatgc gaattaagaa gaaacaaagg
      7510       7520       7530       7540       7550       7560
caacgcgtct ttccacagcc aggcagtctg tatcttgcaa aaacatccac tctgcctcga
      7570       7580       7590       7600       7610       7620
atctctctga aagcagcagt aggaggccaa gttccctctg cgtgttctca taaacagctg
      7630       7640       7650       7660       7670       7680
tatacgtatg gcgtttctaa acattgcata aaaattaaca gcaaaaatgc agagtctttt
      7690       7700       7710       7720       7730       7740
cagtttcaca ctgaagatta ttttggtaag gaaagtttat ggactggaaa aggaatacag
      7750       7760       7770       7780       7790       7800
ttggctgatg gtggatggct cataccctcc aatgatggaa aggctggaaa agaagaattt
      7810       7820       7830       7840       7850       7860
tatagggctc tgtgtgacac tccaggtgtg gatccaaagc ttatttctag aatttgggtt
      7870       7880       7890       7900       7910       7920
tataatcact atagatggat catatggaaa ctggcagcta tggaatgtgc ctttcctaag
      7930       7940       7950       7960       7970       7980
gaatttgcta atagatgcct aagcccagaa agggtgcttc ttcaactaaa atacagatat
      7990       8000       8010       8020       8030       8040
gatacggaaa ttgatagaag cagaagatcg gctataaaaa agataatgga aagggatgac
      8050       8060       8070       8080       8090       8100
acagctgcaa aaacacttgt tctctgtgtt tctgacataa tttcattgag cgcaaatata
      8110       8120       8130       8140       8150       8160
tctgaaactt ctagcaataa aactagtagt gcagataccc aaaaagtggc cattattgaa
      8170       8180       8190       8200       8210       8220
cttacagatg ggtggtatgc tgttaaggcc cagttagatc ctcccctctt agctgtctta
      8230       8240       8250       8260       8270       8280
aagaatggca gactgacagt tggtcagaag attattcttc atggagcaga actggtgggc
      8290       8300       8310       8320       8330       8340
tctcctgatg cctgtacacc tcttgaagcc ccagaatctc ttatgttaaa gatttctgct
      8350       8360       8370       8380       8390       8400
aacagtactc ggcctgctcg ctggtatacc aaacttggat tctttcctga ccctagacct
      8410       8420       8430       8440       8450       8460
tttcctctgc ccttatcatc gcttttcagt gatggaggaa atgttggttg tgttgatgta
      8470       8480       8490       8500       8510       8520
attattcaaa gagcataccc tatacagtgg atggagaaga catcatctgg attatacata
      8530       8540       8550       8560       8570       8580
tttcgcaatg aaagagagga agaaaaggaa gcagcaaaat atgtggaggc ccaacaaaag
      8590       8600       8610       8620       8630       8640
agactagaag ccttattcac taaaattcag gaggaatttg aagaacatga agaaaacaca
      8650       8660       8670       8680       8690       8700
acaaaaccat atttaccatc acgtgcacta acaagacagc aagttcgtgc tttgcaagat
      8710       8720       8730       8740       8750       8760
ggtgcagagc tttatgaagc agtgaagaat gcagcagacc cagcttacct tgagggttat
      8770       8780       8790       8800       8810       8820
ttcagtgaag agcagttaag agccttgaat aatcacaggc aaatgttgaa tgataagaaa
      8830       8840       8850       8860       8870       8880
caagctcaga tccagttgga aattaggaag gccatggaat ctgctgaaca aaaggaacaa
      8890       8900       8910       8920       8930       8940
ggtttatcaa gggatgtcac aaccgtgtgg aagttgcgta ttgtaagcta ttcaaaaaaa
      8950       8960       8970       8980       8990       9000
gaaaaagatt cagttatact gagtatttgg cgtccatcat cagatttata ttctctgtta
      9010       9020       9030       9040       9050       9060
acagaaggaa agagatacag aatttatcat cttgcaactt caaaatctaa aagtaaatct
      9070       9080       9090       9100       9110       9120
gaaagagcta acatacagtt agcagcgaca aaaaaaactc agtatcaaca actaccggtt
      9130       9140       9150       9160       9170       9180
tcagatgaaa ttttatttca gatttaccag ccacgggagc cccttcactt cagcaaattt
      9190       9200       9210       9220       9230       9240
ttagatccag actttcagcc atcttgttct gaggtggacc taataggatt tgtcgtttct
      9250       9260       9270       9280       9290       9300
gttgtgaaaa aaacaggact tgcccctttc gtctatttgt cagacgaatg ttacaattta
      9310       9320       9330       9340       9350       9360
ctggcaataa agttttggat agaccttaat gaggacatta ttaagcctca tatgttaatt
      9370       9380       9390       9400       9410       9420
gctgcaagca acctccagtg gcgaccagaa tccaaatcag gccttcttac tttatttgct
      9430       9440       9450       9460       9470       9480
ggagattttt ctgtgttttc tgctagtcca aaagagggcc actttcaaga gacattcaac
      9490       9500       9510       9520       9530       9540
aaaatgaaaa atactgttga gaatattgac atactttgca atgaagcaga aaacaagctt
      9550       9560       9570       9580       9590       9600
atgcatatac tgcatgcaaa tgatcccaag tggtccaccc caactaaaga ctgtacttca
      9610       9620       9630       9640       9650       9660
gggccgtaca ctgctcaaat cattcctggt acaggaaaca agcttctgat gtcttctcct
      9670       9680       9690       9700       9710       9720
aattgtgaga tatattatca aagtccttta tcactttgta tggccaaaag gaagtctgtt
      9730       9740       9750       9760       9770       9780
tccacacctg tctcagccca gatgacttca aagtcttgta aaggggagaa agagattgat
      9790       9800       9810       9820       9830       9840
gaccaaaaga actgcaaaaa gagaagagcc ttggatttct tgagtagact gcctttacct
      9850       9860       9870       9880       9890       9900
ccacctgtta gtcccatttg tacatttgtt tctccggctg cacagaaggc atttcagcca
      9910       9920       9930       9940       9950       9960
ccaaggagtt gtggcaccaa atacgaaaca cccataaaga aaaaagaact gaattctcct
      9970       9980       9990      10000      10010      10020
cagatgactc catttaaaaa attcaatgaa atttctcttt tggaaagtaa ttcaatagct
     10030      10040      10050      10060      10070      10080
gacgaagaac ttgcattgat aaatacccaa gctcttttgt ctggttcaac aggagaaaaa
     10090      10100      10110      10120      10130      10140
caatttatat ctgtcagtga atccactagg actgctccca ccagttcaga agattatctc
     10150      10160      10170      10180      10190      10200
agactgaaac gacgttgtac tacatctctg atcaaagaac aggagagttc ccaggccagt
     10210      10220      10230      10240      10250
acggaagaat gtgagaaaaa taagcaggac acaattacaa ctaaaaaata tatctaa

Last modification date: Oct. 2, 2011